浅谈项目法人如何做好项目投资管理的建议和措施

水利工程抓好工程建设管理,是保证工程安全的关键,项目法人投资控制是建设管理的重要内容。本文结合多年建设管理经验,通过分析提出了一些观点,以利项目法人强化投资管理,确保投资目标的顺利实现。     

PVP and surfactant combined carrier as an effective absorption enhancer of poorly soluble astilbin in vitro and in vivo

Context: Astilbin is considered to be a new and promising immunosuppressant for immune related diseases, but limited in clinical application due to its poor water solubility, difficult oral absorption and low bioavailability.

Objective: The present work studied the effect of PVP and surfactant combined carrier on its capability to improve drug absorption.

Materials and methods: PVP K30-Tween 80 combined carries was applied into the astilbin solid dispersions, tested both in vivo in beagle dogs and in vitro in transport experiments across Caco-2 cell monolayers.

Results and discussion: In the animal studies a many fold increase in plasma AUC was observed for the solid dispersions of drug in PVP K30-Tween 80 combined carries compared to active pharmaceutical ingredient (API). The applicability of Caco-2 monolayers as a tool for predicting the in vivo transport behavior of Astilbin in combination with a solubility enhancing carries was shown. In vitro transport studies confirmed the effect of combined carries on the absorption behavior of the astilbin. MTT studies showed the cell viability gradually decreased with the increase of the drug concentration in a dose dependent manner for astilbin and that in solid dispersions. The permeability and apparent permeability coefficients (P_app) increased with drug in the Caco-2 cell.

Conclusion: In this study, it was found that PVP K30 and Tween 80 promoted the permeability of drugs best within a certain amount. For astilbin PVP K30 and surfactant combined carrier had a strong potential to improve oral bioavailability.     

VARTM工艺中高渗透导流介质对树脂充填行为的影响

采用可视化流动实验装置,系统研究了高渗透导流介质对真空辅助树脂传递模塑(VARTM)工艺中树脂充填流动行为的影响。实验结果表明,高渗透导流介质只覆盖部分纤维增强体时,铺放在靠注胶端导流效果明显,铺放在靠抽气端导流效果很弱;高渗透导流介质铺放在纤维增强体顶、中和底面任何位置,都会起到良好的导流效果,尤其是铺放在纤维增强体底面时导流效果最好;随着高渗透导流介质层数增加,对树脂充填的导流作用就越好;随着纤维增强体层数的增多,完成充填所需时间就越长,这表明高渗透导流介质导流效果受到增强体厚度的影响。     

Reliability of the doping concentration in an ultra-thin body and buried oxide silicon on insulator (SOI) and comparison with a partially depleted SOI

This study compares the reliability of nMOSFETs with low- and high-doped ultra-thin body and buried oxide (UTBB) with fully depleted (FD) and partially depleted (PD) silicon on insulator (SOI). The high-doped devices display lower off-current leakage performance but more degradation in both hot-carrier stress (HCS) and positive bias temperature instability (PBTI) test at both room temperature and elevated temperature compared with the low-doped devices. The PBTI test indicates that the high-doped devices induce high tunneling leakage and that the degradation is highly associated with temperature. The degradation stabilizes with an increase in stress time. The thinner PD-SOI demonstrates low variation at the threshold voltage and low drive current under HCS. The FD-SOI has better drain leakage control than the PD-SOI.     

YF_3∶Yb,Er纳米晶的固相合成及上转换发光性能

采用一种简单的低温固相法制备了YF3∶Yb,Er纳米晶,重点探究了烧结温度、烧结时间对纳米晶微结构及发光性能的影响。通过XRD、SEM和FA对样品进行了表征。XRD结果表明:烧结温度达到400℃,烧结时间达到1h,即可获得正交相的YF3∶Yb,Er纳米晶;SEM分析表明:制备的YF3∶Yb,Er纳米晶呈现光滑的类球形,粒径随烧结温度升高及烧结时间增加而变大;FA结果显示:在980nm红外激光激发下,样品的可见光发射峰分别位于波长409、524、547和657nm处,其强度与烧结温度、烧结时间正相关。     

基于ASP模式及XML技术的企业资源信息集成研究

为满足企业资源信息集成的需求,提出基于ASP模式以XML文件作为企业资源信息集成方案。运用面向对象思想,构建了企业资源信息模型,并给出了满足ASP需求的企业资源集成系统体系结构。然后以设备资源管理系统和CAPP系统企业资源映射规则为例,讨论了企业资源模型映射技术。最后利用JDOM组件实现了XML文件的生成与解析。提出了一套支持企业资源信息集成的解决方法,实现了网络环境下企业资源数据的交换与共享。     

三价铬电镀技术研究进展

回顾了三价铬电镀的发展历程,介绍了硫酸盐体系三价铬电镀装饰铬的新工艺。新工艺镀铬速度增加到0.057～0.077μm/min,并且速度不随时间而变化。镀液性能稳定,操作简单,便于维护。镀层质量优良,色泽美观,厚度能够达到0.3μm以上。中性盐雾试验、恒定湿热试验、冷热冲击试验、人造汗液测试、抗化学污染测试均能满足行业标准的要求。新工艺性能优越,能够更好地满足广大客户的要求。     

汽车行驶模式智能控制系统的研究

介绍了汽车行驶模式实验室模拟的重要性，分析了控制对象的一些特性，提出了基于这些特性的智能控制方法，设计了一套测试，控制和管理的软硬件系统，实现了几种典型的汽车行驶模式模拟。     

An empirical model to describe the non-isothermal ageing behaviour of feroplug materials

Feroplug is a new temperature indicator developed by the authers and co-workers. The device makes use of the characteristics of ferrite transformation in duplex stainless steels, and has the following advantages over conventional methods of temperature measurement:

1. (1) It is a piece of stainless steel, with no delicate parts, and can be used in very hostile environments;

2. (2) It does not require any cables such as those in the case of thermocouples;

3. (3) It is very much cheaper than thermocouples.

This invention has been patented in the USA, UK and Europe with financial and legal support provided by the British Technology Group, UK. Patent application in Japan is still pending.

The invention is particularly useful for life assessment purposes in power and petrochemical plants. The underlying physical principle of the Feroplug is based on the transformation of ferrite, which is ferromagnetic at room temperature, into other phases such as carbide and sigma which are nonferomagnetic at room temperature. The amount of transformation depends on the temperature and duration of exposure. If the amount of transformation and time of exposure is known, the temperature of exposure can be deduced. Thus, the Feroplug makes use of the change in the amount of ferrite, which can be easily detected by room temperature magnetic measurement, to indicate the temperature of exposure. A model has been developed which can describe the ferrite transformation behaviour of Feroplug materials under non-isothermal conditions. The agreement between experimental data and the model is good at temperatures above 550°C.