Automated speech recognition for spreadsheet tasks: Performance effects for experts and novices

The performance of spreadsheet users was compared for two modes of input to the computer, keyboard and automated speech recognition (ASR). Subjects from both an expert group and a novice group were also classified by decision style. Dependent measures were task completion time, accuracy, keystroke count, correction count, and user confidence. Results for a speaker‐dependent, discrete‐word recognizer showed that, for both simple data input and more complex analytical spreadsheet tasks, neither the experts nor the novices performed more effectively using ASR. However, both groups expressed the desirability of having speech input as an option for desktop computing.     

'Tacitus' project: identifying multi-sensory perceptions in creative 3D practice for the development of a haptic computing system for applied artists

This paper outlines the major motivating factors concerning a novel collaborative project between Edinburgh College of Art and Edinburgh Virtual Environment Centre. The Tacitus project will investigate the use of multi-modal virtual environments, specifically, the haptic (touch) modality, with regards to the creative processes employed by designers working within the field of applied arts. The salient areas of research are described, and the methods by which information regarding these areas will be obtained are considered. Initial investigations have revealed a strong need to mimic the traditional applied artists' workspaces, with co-location of visual and haptic cues a priority.     

Reversible inactivation of purified leukocyte integrin CR3 (CD11b/CD18, alpha m beta 2) by removal of divalent cations from a cryptic site

Integrins exhibit reversible changes in their ability to bind ligands and these changes enable transient cell adhesion. We recently showed that leukocyte integrin CR3 (complement receptor type three, CD11b/CD18, alpha m beta 2) may be purified in a form that is either capable or incapable of binding soluble, monomeric ligand and that "inactive" CR3 may be rendered capable of binding ligand by addition of an anti-CR3 mAb known as KIM-127 (Cai and Wright, JBC. 270: 14358, 1995). Here, we demonstrate that active CR3 may be rendered inactive by treatment of immobilized receptor with EDTA. EDTA-treated CR3 failed to bind ligand even in the presence of mM Ca2+ and Mg2+, suggesting that EDTA-treatment caused a change in the receptor that is not readily reversed. EDTA-treated receptor did, however, bind ligand upon addition of KIM-127 plus Mg2+ with an affinity (17.8 +/- 4.5 nM) similar to untreated, active receptor (12.5 +/- 4.7 nM). EDTA-treated CR3 thus exhibits the properties of inactive CR3, in which the ligand binding site is cryptic but subject to exposure by KIM-127. A candidate for the cryptic ligand binding site is the I-domain, a Mg2+-binding region in the alpha chain of CR3. We found that monomeric C3bi binds directly to recombinant I-domain in a Mg(2+)-dependent fashion with an affinity of 300 +/- 113 nM. These results thus suggest that CR3 may be inactivated by removing tightly bound divalent cation from a cryptic site in CR3.     

In Situ Electrical Network Activation and Deactivation in Short Carbon Fiber Composites via 3D Printing

Prior studies on carbon-filler based, conductive polymer composites have mainly investigated how conductive filler morphology and concentration can tailor a material's electrical conductivity and overlooks the effects of filler alignment due to the difficulty to control and quickly quantify the filler alignment. Here, direct ink write 3D printing's unique ability is utilized to control carbon fiber alignment with a single process parameter, velocity ratio, to instantaneously activate or deactivate the electrical network in composites. Maximum electrical conductivity is achieved by randomly aligning carbon fibers that enhances the chance of direct fiber-to-fiber contact and, thus, activating the electrical network. However, aligning the fibers by increasing the velocity ratio disrupts the electrical network by minimizing fiber-to-fiber contact that resulted in a drastic decrease in electrical conductivity by as much as five orders of magnitude in both short and long carbon fiber composites. With this study, this study demonstrates that electrically conductive or insulative composites can be fabricated sequentially with a single ink. This novel ability to instantaneously control the electrical conductivity of carbon fiber reinforced composites allow to directly embed conductive pathways into designs to 3D print multifunctional composites that are capable of localized heating and self-sensing.     

Oxygen saturation-dependent effects on blood transverse relaxation at low fields

Objective

Blood oxygenation can be measured using magnetic resonance using the paramagnetic effect of deoxy-haemoglobin, which decreases the \(\textit{T}_{2}\) relaxation time of blood. This \(\textit{T}_{2}\) contrast has been well characterised at the \(\textit{B}_{{0}}\) fields used in MRI (1.5 T and above). However, few studies have characterised this effect at lower magnetic fields. Here, the feasibility of blood oximetry at low field based on \(\textit{T}_{2}\) changes that are within a physiological relevant range is explored. This study could be used for specifying requirements for construction of a monitoring device based on low field permanent magnet systems.

Methods

A continuous flow circuit was used to control parameters such as oxygen saturation and temperature in a sample of blood. It flowed through a variable field magnet, where CPMG experiments were performed to measure its \(\textit{T}_{2}\). In addition, the oxygen saturation was monitored by an optical sensor for comparison with the \(\textit{T}_{2}\) changes.

Results

These results show that at low \(\textit{B}_{{0}}\) fields, the change in blood \(\textit{T}_{2}\) due to oxygenation is small, but still detectable. The data measured at low fields are also in agreement with theoretical models for the oxy-deoxy \(\textit{T}_{2}\) effect.

Conclusion

\(\textit{T}_{2}\) changes in blood due to oxygenation were observed at fields as low as 0.1 T. These results suggest that low field NMR relaxometry devices around 0.3 T could be designed to detect changes in blood oxygenation.

     

The simple genetic algorithm and the Walsh transform: Part I, Theory

This paper is the first part of a two-part series. It proves a number of direct relationships between the Fourier transform and the simple genetic algorithm. (For a binary representation, the Walsh transform is the Fourier transform). The results are of a theoretical nature and are based on the analysis of mutation and crossover. The Fourier transform of the mixing matrix is shown to be sparse. An explicit formula is given for the spectrum of the differential of the mixing transformation. By using the Fourier representation and the fast Fourier transform, one generation of the infinite population simple genetic algorithm can be computed in time O(cllog2(3)), where c is arity of the alphabet and l is the string length. This is in contrast to the time of O(c3l) for the algorithm as represented in the standard basis. There are two orthogonal decompositions of population space that are invariant under mixing. The sequel to this paper will apply the basic theoretical results obtained here to inverse problems and asymptotic behavior.     

The simple genetic algorithm and the Walsh transform: Part II, The inverse

This paper continues the development, begun in Part I, of the relationship between the simple genetic algorithm and the Walsh transform. The mixing scheme (comprised of crossover and mutation) is essentially "triangularized" when expressed in terms of the Walsh basis. This leads to a formulation of the inverse of the expected next generation operator. The fixed points of the mixing scheme are also determined, and a formula is obtained giving the fixed point corresponding to any starting population. Geiringer's theorem follows from these results in the special case corresponding to zero mutation.     

Temperature distributions in laser-heated semi-infinite and finite-thickness media with convective surface losses

The temperature distributions produced within semi-infinite and finite-thickness media heated by a moving laser beam with a Gaussian power-density profile are examined by use of a time-domain method. Convective losses, described by Newton's law of cooling, from the medium surfaces are included. Various medium absorption models are considered. The solutions are given as single integrals with respect to time of simple functions. The resulting expressions have been used to examine the role of surface losses in information storage and medical applications. The role of convective losses in optical recording systems is found to be insignificant. However, for medical applications, combined convective and evaporative surface losses represent an important surface-heat-loss mechanism.     

Laparoscopic versus open appendectomy

BACKGROUND: Clinical manifestations and course of sickle-cell anemia are variable. Knowledge about the factors, possibly geographic, that influence prognosis are still scanty. POPULATION AND METHODS: Data of hospitalization and management of children with sickle-cell disease were studied during two years (1992-1993) in the Pediatric Unit of Libreville Hospital. They concerned 205 admissions of 171 children and 131 outpatients. RESULTS: The main causes of hospitalization were: acute anemia (36 cases before the age of 5 years); painful crisis whose frequency increased with age (23% before 5 years, 35% between 5 and 10, 42% after 10 years); infections, essentially pulmonary occurring early, and bone infections at any age. Eight children died (because a complication of their disease). Among the 131 outpatients, half were detected because pyrexia, anemia and/or more often "hand-foot syndrome". More than 60% had hepatomegaly, one third still had splenomegaly after five years of age and more than one third was icteric. More than half children older than ten years had growth disorders. Mean hemoglobin level was 7 g/dL. 21 of the 83 tested children for HBsAg were positive and only one out of 79 was positive for HIV. CONCLUSIONS: Clinical manifestations and course of sickle-cell anemia in our patients are similar to those reported in Congolese children. Genetic and environmental factors may be responsible for differences with children from other, in particular French, cohorts.     

Enabledness and termination in refinement algebra

Refinement algebras are abstract algebras for reasoning about programs in a total correctness framework. We extend a reduct of von Wright’s demonic refinement algebra with two operators for modelling enabledness and termination of programs. We show how the operators can be used for expressing relations between programs and apply the algebra to reasoning about action systems.