Computer-based spelling remediation for dyslexic children

Abstract The SelfSpell programs provide a multi-media environment for dyslexic children which uses synthesised speech to augment the written text. In earlier research we established that by encouraging users to enter a rule to help them remember how to spell each word, SelfSpell was very effective in improving spelling ability. The evaluation study reported here confirmed the efficacy of the rule-based approach using a group of 11-year-old dyslexic children with severe impairments in spelling. Of particular theoretical significance, however, was the finding that use of a mastery learning technique for learning spellings was just as effective as the rule-based approach. These findings are interpreted in the light of Frith's influential framework for the development of reading and spelling ability. It is suggested that the multimedia presentation approach may provide a uniquely effective method for helping dyslexic children to acquire the 'alphabetic' stage of linguistic processing.     

Limited expansion of the (CAG)n repeat of the Huntington gene: a premutation (?)

Pantoprazole is a specific inhibitor of the H+/K(+)-ATPase of the gastric parietal cell. The dose-dependency of a range of pantoprazole pharmacokinetic characteristics was studied. Twelve healthy male subjects were given 10, 20, 40 and 80 mg pantoprazole intravenously according to a randomized, single blind, 4-period change-over scheme. The area under the concentration vs time curve (AUC) and the maximum serum concentration (Cmax) showed a linear increase in line with the dose. Apparent volume of distribution (Vd area), clearance (Cl) and terminal half-life (t1/2) were independent of the dose. The dose-independent elimination of pantoprazole was attributed to the lack of interaction of the drug with cytochrome P450. In clinical practice, a good predictable response, as well as a low potential for interaction with other drugs might be expected.     

Factors in American State Government spending on research and development

This paper investigates factors that lead state governments in the United States to spend on research and development and research and development plant. Data come from a national survey of such spending. Regression analysis is used. Findings include the following: the relative wealth of a state, as measured by its tax capacity, predicts some of such spending; the level of a state's taxation, as measured by its tax effort, predicts some of such spending; and the political party composition of a state predicts some of such spending. By contrast, a state's economic difficulty, as measured by its unemployment rate, has almost no relationship to such spending.     

Programs of early detection of breast cancer and access of mammography in Spain

BACKGROUND: We studied availability to mammography among Spanish women aged 40 to 70 years, variation in use of the mammography by autonomous community, and the situation and importance of breast cancer screening programs among other factors, in the access to mammography. SUBJECTS AND METHODS: A cross-sectional population survey was conducted in 1994 in a sample of 3,218 women. A questionnaire was used to collect data on the variable access (receipt of at least one mammogram in the last 2 years) as well as different access-related variables. Information on breast cancer screening programs was collected by contacting the responsible institutions. We considered that a program had total coverage if it included all the municipalities in the province and partial if it did not include all municipalities. RESULTS: Twenty-eight percent of women had performed a mammogram. This proportion varied among autonomous communities (AACC) from 11.5 to 73.8%. Breast cancer screening programs existed in 8 AACC. The multivariant analysis revealed an association between access to mammography and the existence of a screening program, especially when the later had total coverage (OR = 7.64; 95% CI = 5.24-11.10). An association was also found between access to mammography and physician-related factors, place of residence and attitudes of women toward mammography. CONCLUSIONS: Less than one third of women aged 40-70 have performed a mammography in the last 2 years, and this proportion varies among AACC. Gynecologist visits and the existence of breast cancer screening programs are fundamental factors in the access to mammography in Spain.     

A comprehensive study of performance and reliability of P, As, andhybrid As/P nLDD junctions for deep-submicron CMOS logic technology

A comprehensive study of P, As, and hybrid As/P nLDD junctions is presented in terms of performance, reliability, and manufacturability for the first time. It is found that As junctions limit the performance of deep submicron devices due to unacceptable hot-carrier reliability, whereas a hybrid junction (light dose P added to medium dose As) dramatically improves hot-carrier reliability while maintaining high performance and manufacturability. For L_eff of 0.19 μm, using this hybrid junction in a manufacturing process, an inverter gate delay of 32 ps, dc hot carrier life time exceeding ten years, and off-state leakage below 30 pA/μm at 2.9 V have been achieved     

Psychopathy and alexithymia in female offenders.

Determined the comorbidity of psychopathy and alexithymia in 37 female inmates of a medium-security prison. The authors also investigated the association between psychopathy and alexithymia with the use of affective language in response to questions about an emotional event, and with their propensity for violence. The extent of psychopathy and alexithymia were assessed with the Hare Psychopathy Checklist—Revised (PCL-R) and the Toronto Alexithymia Scale (TAS), respectively. Using standard cutoff scores, 30% were identified as psychopaths, and 32% as alexithymics. Three Ss were both psychopaths and alexithymics. The correlation between PCL-R and TAS total scores was not significant, but the socially deviant impulsive factor of the PCL-R significantly correlated with the TAS items that reflect inability to discriminate feelings and bodily sensations. Alexithymia, but not psychopathy, was negatively related to measures of affective speech content. Both psychopathy and alexithymia were associated with a history of violence. In spite of several manifest similarities, psychopathy and alexithymia appear to be different clinical constructs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structural modelling of coprecipitated VTiO catalysts

A statistical study of the particle shape and size of pure V₂O₅ and TiO₂, and samples of coprecipitated V₂O₅---TiO₂ catalysts with different V/Ti ratios, has been performed. They were also characterized by XRD, EDAX, SEM and XPS. The results showed that pure vanadium pentoxide is compose by large square or needle-shaped particles, while pure titanium dioxide has small and rounded ones. VTiO samples presented an area and shape, depending on the V/Ti ratio.

These results and the spectroscopical characterization conducted to a particle model of the catalysts. Those VOTi samples with high V/Ti ratio would have large V₂O₅ crystals acting as support of a V/TiO₂ solid solution. In contrast, those samples with a low V/Ti ratio, would have the solid solution supporting vanadium pentoxide crystals.     

Magnetic field detection enhancement in an external cavity fiberFabry-Perot sensor

The sensitivity of an extrinsic fiber-optic magnetic field sensor using a gallium doped yttrium iron garnet (Ga:YIG) bulk optic crystal has been significantly improved by incorporating a Fabry-Perot resonator around the crystal