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81.
82.
This paper uses a partially ordered set of syntactic categories to accommodate optionality and licensing in natural language
syntax. A complex but well-studied data set pertaining to the syntax of quantifier scope and negative polarity licensing in
Hungarian is used to illustrate the proposal. The presentation is geared towards both linguists and logicians. The paper highlights
that the main ideas can be implemented in different grammar formalisms, and discusses in detail an implementation where the
partial ordering on categories is given by the derivability relation of a calculus with residuated and Galois-connected unary
operators. 相似文献
83.
Daria Brambilla Cesare Mancuso Mariagrazia Rita Scuderi Paolo Bosco Giuseppina Cantarella Laurence Lempereur Giulia Di Benedetto Salvatore Pezzino Renato Bernardini 《Nutrition journal》2008,7(1):29
This review will discuss some issues related to the risk/benefit profile of the use of dietary antioxidants. Thus, recent
progress regarding the potential benefit of dietary antioxidants in the treatment of chronic diseases with a special focus
on immune system and neurodegenerative disorders will be discussed here. It is well established that reactive oxygen species
(ROS) play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes and cancer. Among the
physiological defense system of the cell, the relevance of antioxidant molecules, such as glutathione and vitamins is quite
well established. Recently, the interest of researchers has, for example, been conveyed on antioxidant enzyme systems, such
as the heme oxygenase/biliverdin reductase system, which appears modulated by dietary antioxidant molecules, including polyphenols
and beta-carotene. These systems possibly counteract oxidative damage very efficiently and finally modulate the activity of
oxidative phenomena occurring, for instance, during pathophysiological processes. Although evidence shows that antioxidant
treatment results in cytoprotection, the potential clinical benefit deriving from both nutritional and supplemental antioxidants
is still under wide debate. In this line, the inappropriate assumption of some lipophylic vitamins has been associated with
increased incidence of cancer rather than with beneficial effects. 相似文献
84.
Paola Salvadeo Raffaella BoggiaFilippo Evangelisti Paola Zunin 《Food chemistry》2007,105(3):1228-1235
This paper describes the development and application of a new analytical method for the analysis of the volatile fractions of pesto, a typical Italian basil-based pasta sauce, and its ingredients. The extraction of the volatile fraction was realized by headspace sorptive extraction (HSSE) and the extracted volatiles were then thermodesorbed, cryoconcentrated in a cooled injector and analysed by gas chromatography-mass spectrometry. 相似文献
85.
Raffaella Gianferri Virginia D’AiutoRoberta Curini Maurizio DelfiniElvino Brosio 《Food chemistry》2007,105(2):720-726
Proton transverse magnetization decay curves of Mozzarella di Bufala Campana samples were measured and analysed for the presence in the sample of four components, namely “serum water”, “entrapped water”, “junction zone water” and “fat”, characterised by different transverse relaxation times, T2. T2 values were interpreted on the basis of the diffusive and chemical exchange model that allowed information to be obtained on the size of diffusive domains and dynamics of the water molecules. Furthermore, T2 values were measured as a function of the aging time of Mozzarella samples, as produced by different cheese-makers. A decrease of “serum water” T2 value with aging time was found and this may be used to monitor the evolution of Mozzarella samples up to seven days after manufacture. 相似文献
86.
P Villa D Valle A Mancini L De Marinis V Pavone AM Fulghesu S Mancuso A Lanzone 《Canadian Metallurgical Quarterly》1999,71(1):115-121
Amplitude-coded color Doppler sonography (ACD) has become an useful adjunct to gray-scale US and conventional color Doppler sonography (CD) for the assessment of vascular diseases and pathologic conditions that might affect or alter tissue vascularization or perfusion. Basically, all US units that generate conventional color Doppler information through autocorrelation technique are capable of displaying ACD. This technique is also referred to as power Doppler, amplitude-mode color Doppler US, color Doppler energy (CDE), or US angiography. Amplitude-coded color Doppler sonography has already emerged as a valuable adjunct to conventional CD, particularly for evaluating flow in parts of the body where CD signal is weak because of slow flow, small blood vessels, or both. 相似文献
87.
Use of sourdough fermented wheat germ for enhancing the nutritional, texture and sensory characteristics of the white bread 总被引:3,自引:1,他引:3
Carlo Giuseppe Rizzello Luana Nionelli Rossana Coda Raffaella Di Cagno Marco Gobbetti 《European Food Research and Technology》2010,230(4):645-654
Lactobacillus plantarum LB1 and Lactobacillus rossiae LB5, isolated from wheat germ and selected based on the kinetics of acidification, were used as starters for the manufacture
of sourdough fermented wheat germ. A bread containing sourdough fermented wheat germ as an ingredient (SFWGB) was compared
to breads made with (raw wheat germ bread, RWGB) or without (wheat flour bread, WFB) raw wheat germ. The higher concentration
of free amino acids mainly differentiated SFWGB from WFB and RWGB. The in vitro protein digestibility of WFB was the highest,
even if sourdough fermentation of wheat germ attenuated the difference. Phytase and antioxidant activities of SFWGB were highest.
The specific volume and cell-total areas were also the highest for SFWGB. As determined by texture profile analysis, the values
of hardness, resilience and fracturability of breads containing wheat germ were lower than those found in WFB. The crust lightness
showed a decrease from WFB to SFWGB. As determined by sensory analysis, SFWGB had mainly acid taste and flavour and resulted
more salty. Sourdough fermented wheat germ is an ingredient able to enhance nutritional, texture and sensory properties of
bread. 相似文献
88.
Agnese Graziosi Giulia Sita Camilla Corrieri Sabrina Angelini Roberta dEmmanuele di Villa Bianca Emma Mitidieri Raffaella Sorrentino Patrizia Hrelia Fabiana Morroni 《International journal of molecular sciences》2022,23(23)
Endocrine-disrupting chemicals (EDCs) are different natural and synthetic chemicals that may interfere with several mechanisms of the endocrine system producing adverse developmental, metabolic, reproductive, and neurological effects in both human beings and wildlife. Among pesticides, numerous chemicals have been identified as EDCs. MicroRNAs (miRNAs) can regulate gene expression, making fine adjustments in mRNA abundance and regulating proteostasis. We hypothesized that exposure to low doses of atrazine, cypermethrin, and vinclozolin may lead to effects on miRNA expression in SH-SY5Y cells. In particular, the exposure of SH-SY5Y cells to subtoxic concentrations of vinclozolin is able to downregulate miR-29b-3p expression leading to the increase in the related gene expression of ADAM12 and CDK6, which may promote a pro-oncogenic response through the activation of the PI3K/Akt/mTOR pathway and counteracting p53 activity. A better understanding of the molecular mechanisms of EDCs could provide important insight into their role in human disease. 相似文献
89.
Piervito Lopriore Fbio Gomes Vincenzo Montano Gabriele Siciliano Michelangelo Mancuso 《International journal of molecular sciences》2022,23(21)
Primary mitochondrial diseases are relatively common inborn errors of energy metabolism, with a combined prevalence of 1 in 4300. These disorders typically affect tissues with high energy requirements, including the brain. Epilepsy affects >1% of the worldwide population, making it one of the most common neurological illnesses; it may be the presenting feature of a mitochondrial disease, but is often part of a multisystem clinical presentation. The major genetic causes of mitochondrial epilepsy are mutations in mitochondrial DNA and in the nuclear-encoded gene POLG. Treatment of mitochondrial epilepsy may be challenging, often representing a poor prognostic feature. This narrative review will cover the most recent advances in the field of mitochondrial epilepsy, from pathophysiology and genetic etiologies to phenotype and treatment options. 相似文献
90.
Micaela Tirri Raffaella Arf Sabrine Bilel Giorgia Corli Beatrice Marchetti Anna Fantinati Fabrizio Vincenzi Fabio De-Giorgio Cristian Camuto Monica Mazzarino Mario Barbieri Rosa Maria Gaudio Katia Varani Pier Andrea Borea Francesco Botr Matteo Marti 《International journal of molecular sciences》2022,23(14)
3-(1-Naphthalenylmethyl)-1-pentyl-1H-indole (JWH-175) is a synthetic cannabinoid illegally marketed for its psychoactive cannabis-like effects. This study aimed to investigate and compare in vitro and in vivo pharmacodynamic activity of JWH-175 with that of 1-naphthalenyl (1-pentyl-1H-indol-3-yl)-methanone (JWH-018), as well as evaluate the in vitro (human liver microsomes) and in vivo (urine and plasma of CD-1 male mice) metabolic profile of JWH-175. In vitro binding studies showed that JWH-175 is a cannabinoid receptor agonist less potent than JWH-018 on mouse and human CB1 and CB2 receptors. In agreement with in vitro data, JWH-175 reduced the fESPS in brain hippocampal slices of mice less effectively than JWH-018. Similarly, in vivo behavioral studies showed that JWH-175 impaired sensorimotor responses, reduced breath rate and motor activity, and increased pain threshold to mechanical stimuli less potently than JWH-018. Metabolic studies demonstrated that JWH-175 is rapidly bioactivated to JWH-018 in mice blood, suggesting that in vivo effects of JWH-175 are also due to JWH-018 formation. The pharmaco-toxicological profile of JWH-175 was characterized for the first time, proving its in vivo bio-activation to the more potent agonist JWH-018. Thus, it highlighted the great importance of investigating the in vivo metabolism of synthetic cannabinoids for both clinical toxicology and forensic purposes. 相似文献