The effect of lidocaine on growth of cells of head and neck squamous cell carcinoma

The relation between 21 absolute body dimensions as well as 20 anthropometric indices and the length as well as the regularity of the menstrual cycle have been investigated in 156 patients of the hormone ambulance of the I. Universit?ts-Frauenklinik in Vienna. It turned out, that the length as well as the regularity of the menstrual cycle significantly negatively with the amount of the subcutaneous fat tissue. With an increasing amount of adipose tissue, the cycle became shorter and more regular. The importance of the subcutaneous fat tissue as a secondary hormonal gland has been discussed as one cause for these significant connections. Regarding the length- and height dimensions and the menstrual cycle patterns, no statistically significantly relationship could be observed between these two trait system. This is also true for the relationship between body built and the bleeding duration.     

Synthesis of Co3 O4 /graphene nanocomposite using paraffin wax for adsorption of methyl violet in water

This study discusses the use of Co₃ O₄ impregnated graphene (CoOIG) as an efficient adsorbent for the removal of methyl violet (MV) dye from wastewater. CoOIG nanocomposites have been prepared by pyrolyzing paraffin wax with cobalt acetate. The synthesised nanocomposite was characterised by X‐ray diffraction, field emission scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscope, Raman spectroscopy, and Brunauer–Emmett–Teller isotherm studies. The above studies indicate that the composites have cobalt oxide nanoparticles of size 51–58 nm embedded in the graphene nanoparticles. The adsorption studies were conducted with various parameters, pH, temperature and initial dye concentration, adsorbent dosage and contact time by the batch method. The adsorption of MV dye by the adsorbent CoOIG was about 90% initially at 15 min and 98% dye removal at pH 5. The data were fitted in Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich and Sips isotherm models. Various thermodynamic parameters like Gibbs free energy, enthalpy, and entropy of the on‐going adsorption process have also been calculated.Inspec keywords: cobalt compounds, graphene, nanoparticles, nanocomposites, nanofabrication, adsorption, dyes, scanning electron microscopy, field emission electron microscopy, transmission electron microscopy, Raman spectra, Fourier transform infrared spectra, free energy, enthalpy, entropyOther keywords: nanocomposite, paraffin wax, adsorption, methyl violet dye, water, X‐ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, Brunauer‐Emmett‐Teller isotherm, cobalt oxide nanoparticles, graphene nanoparticles, thermodynamic parameters, Gibbs free energy, enthalpy, entropy, Co₃ O₄ ‐C     

The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor

MicroRNA-202 (miR-202) is a member of the highly conserved let-7 family that was discovered in Caenorhabditis elegans and recently reported to be involved in cell differentiation and tumor biology. In humans, miR-202 was initially identified in the testis where it was suggested to play a role in spermatogenesis. Subsequent research showed that miR-202 is one of the micro-RNAs that are dysregulated in different types of cancer. During the last decade, a large number of investigations has fortified a role for miR-202 in cancer. However, its functions can be double-edged, depending on context they may be tumor suppressive or oncogenic. In this review, we highlight miR-202 as a potential diagnostic biomarker and as a suppressor of tumorigenesis and metastasis in several types of tumors. We link miR-202 expression levels in tumor types to its involved upstream and downstream signaling molecules and highlight its potential roles in carcinogenesis. Three well-known upstream long non-coding-RNAs (lncRNAs); MALAT1, NORAD, and NEAT1 target miR-202 and inhibit its tumor suppressive function thus fueling cancer progression. Studies on the downstream targets of miR-202 revealed PTEN, AKT, and various oncogenes such as metadherin (MTDH), MYCN, Forkhead box protein R2 (FOXR2) and Kirsten rat sarcoma virus (KRAS). Interestingly, an upregulated level of miR-202 was shown by most of the studies that estimated its expression level in blood or serum of cancer patients, especially in breast cancer. Reduced expression levels of miR-202 in tumor tissues were found to be associated with progression of different types of cancer. It seems likely that miR-202 is embedded in a complex regulatory network related to the nature and the sensitivity of the tumor type and therapeutic (pre)treatments. Its variable roles in tumorigenesis are mediated in part thought its oncogene effectors. However, the currently available data suggest that the involved signaling pathways determine the anti- or pro-tumorigenic outcomes of miR-202’s dysregulation and its value as a diagnostic biomarker.     

Superparamagnetic Nanostructures for Off‐Resonance Magnetic Resonance Spectroscopic Imaging

This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom‐up approach. The composite nanoparticles are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons, which can be demonstrated in MR spectroscopy and imaging to be different from the bulk pool. Moreover, the particles exhibit excellent colloidal stability in aqueous media and good cell biocompatibility. Hence, these particles are potentially useful as biomarkers by taking advantage of the positive contrast effects produced in MRI.     

Network Lifetime Enhancement of Wireless Sensor Networks Using EFRP Protocol

This paper presents a novel transceiver architecture for in-band full duplex radio. A transceiver for full duplex radio requires a self-interference (SI) canceler to remove the SI occurring from the transmitter to the receiver, and a full duplex transceiver generally has two SI cancelers: one at the analog RF stage and the other at the baseband stage. The output from the SI canceler at the RF stage includes much residual SI, and it decreases the number of bits allocated to the analog baseband signal at the analog-to-digital converter. A 1-tap analog baseband SI canceler that uses a replica signal including only the direct path component of the residual SI has been presented for preventing degradation. However, the architecture cannot remove the SI well due to the high Ricial K-factor. To address the problem, the presented architecture has an SI canceler at the analog baseband stage, and this canceler employs a replica signal that is output from a digital-to-analog converter. Because the replica signal is generated in the digital domain, the architecture can generate a multipath replica signal, and improved performance can be expected. Numerical and theoretical analyses are shown to validate the effectiveness of the presented architecture.

     

Analytical model for Binding Refresh Request to reduce storage and communication overhead in MIPv6 network

Home agent is a key component of MIPv6 functionality that comprises binding cache to hold the mobile nodes current point of attachment to the Internet. This paper is concerned with binding cache support for home agents within MIPv6 network. Existing binding cache of home agent supports weak cache consistency by using fixed contract length for Binding Refresh Request, which functions reasonably well in normal situations. However, maintaining a strong binding cache consistency in home agent as a crucial exceptional handling mechanism has become more demanding for the following objectives: (i) to adapt increasingly frequent change of care‐of address due to mobile nodes movement detection update; (ii) to provide fine‐grain controls to balance the binding cache load distributions for better delivery services; and (iii) to reduce the overhead allowances around the binding cache. In this paper, we have first verified the effectiveness of Binding Refresh Request contract length, and on the basis of that, two dynamic contract algorithms are suggested to reduce the storage and communication overhead allowances in binding cache. We have also compared our technique with the existing fixed Binding Refresh Request contract length, and our simulation results reveals that the proposed approach provides an effective performance to reduce overhead within the network. Copyright © 2014 John Wiley & Sons, Ltd.     

Bronchopulmonary dysplasia: the pulmonary pathologic sequel of necrotizing bronchiolitis and pulmonary fibrosis

A light and electron microscopic study was carried out in 21 infants in whom the pathologic diagnosis of bronchopulmonary dysplasia had been made. All the infants except two had the respiratory distress syndrome at birth, and all 21 had been treated with respirator and oxygen therapy for various periods of time. The pathologic alterations observed in all the infants studied were primarily damage of the bronchial and bronchiolar ciliary apparatus and mucous membranes, severe necrotizing bronchiolitis, and marked bronchiolar and alveolar fibrosis. These changes were more pronounced in infants who survived the longest period of time. Such inflammatory and fibrotic changes are known to predispose to destruction of lung tissue, emphysema, and pulmonary hypertension. Six of these 21 infants developed symptoms and signs of cardiac atrial or ventricular stress, including cor pulmonale, prior to their demise. These infants were among those that survived the longest periods of time, had the longest exposure to supplemental oxygen, and showed histopathologically severe pulmonary fibrosis and emphysema.