Leveraging the nugget parameter for efficient Gaussian process modeling

Gaussian process (GP) metamodels have been widely used as surrogates for computer simulations or physical experiments. The heart of GP modeling lies in optimizing the log‐likelihood function with respect to the hyperparameters to fit the model to a set of observations. The complexity of the log‐likelihood function, computational expense, and numerical instabilities challenge this process. These issues limit the applicability of GP models more when the size of the training data set and/or problem dimensionality increase. To address these issues, we develop a novel approach for fitting GP models that significantly improves computational expense and prediction accuracy. Our approach leverages the smoothing effect of the nugget parameter on the log‐likelihood profile to track the evolution of the optimal hyperparameter estimates as the nugget parameter is adaptively varied. The new approach is implemented in the R package GPM and compared to a popular GP modeling R package ( GPfit) for a set of benchmark problems. The effectiveness of the approach is also demonstrated using an engineering problem to learn the constitutive law of a hyperelastic composite where the required level of accuracy in estimating the response gradient necessitates a large training data set.     

Behavior of Double-Oxide Film Defects in Al-0.05?wt pct Sr Alloy

The change in the composition of oxide layers and the possibility of the formation of bonding between the two layers of a double-oxide film defect when held in an Al-0.05?wt pct Sr melt was investigated. The defect was modeled experimentally by maintaining two aluminum oxide layers in contact with one another in the liquid metal at 1023?K (750?°C) for times ranging from 5?seconds to 50?hours. Any changes in the composition and morphology of these layers were studied by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The results showed that the A1₂O₃ layers started to transform to SrO gradually from the moment that they submerged into the melt. The transformation caused the two layers to bond with each other gradually. The results illustrated that the composition of the oxide layers of a double oxide film defect submerged in Sr-treated melt is different from that of pure Al, and this might affect the mechanical properties and the behavior of the defect in the melt significantly.     

Cesarean delivery: a randomized trial of epidural versus patient-controlled meperidine analgesia during labor

Barrett's esophagus is found in about 1% of the older population and in 3% to 5% of persons with gastroesophageal reflux. It is acquired more commonly by men and the prevalence increases with age. Most cases in the population remain undiagnosed. The incidence of adenocarcinoma of the esophagus and esophagogastric junction is increasing, both being related to Barrett's esophagus. Small areas of intestinal metaplasia are common but of uncertain significance.     

A randomized study of combined spinal-epidural analgesia versus intravenous meperidine during labor: impact on cesarean delivery rate

We recently reported on the successful generation of immortalized (CEPI-17-CL4) cells from primary human corneal epithelial (P-CEPI) cells which exhibited phenotypic, immunohistochemical and metabolic characteristics akin to the P-CEPI cells. The aims of the present studies were to investigate the ligand binding and functional coupling of the histamine receptors to various biochemical and physiological systems in the P-CEPI and CEPI-17-CL4 cells and to relate these findings to the normal and/or pathophysiological role of histamine on the human ocular surface. Specific [3H]-pyrilamine binding to CEPI-17-CL4 cell homogenates comprised >93% of the total binding and represented interaction with an apparent single population of high affinity (Kd=3.76+/-0.78 nM; n=4) and saturable (Bmax = 1582+/-161 fmol g(-1) tissue) number of histamine-1 (H1) receptor binding sites on CEPI-17-CL4 cell homogenates. The H1-receptor selective antagonists, pyrilamine (Ki=3.6+/-0.84 nM, n=4) and triprolidine (Ki = 7.7+/-2.6 nM, n=3), potently displaced [3H]-pyrilamine binding, while the H2- and H3-receptor selective antagonists, ranitidine and clobenpropit, were weak inhibitors (K(i)s>13 microM). Histamine induced phosphoinositide (PI) hydrolysis 2.7-4.4 fold above basal levels and with a potency of 14.9+/-4.9 microM (n=9) and 4.7+/-0.2 microM (n=9) in P-CEPI and CEPI-17-CL4 cells, respectively. Histamine-induced PI turnover was antagonized by H1-receptor selective antagonist, triprolidine, with a potency (Ki) of 3.2+/-0.66 nM (n=10) and 3.03+/-0.8 nM (n=4) in P-CEPI and CEPI-17-CL4 cells, respectively, but weakly effected by 10 microM cimetidine and clobenpropit, H2- and H3-receptor antagonists. The PI turnover response was attenuated by pre-treatment of the cells with the selective phospholipase C inhibitor, U73122 (1-(6-((17beta-3-methoxyestra- 1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) (IC50=4.8+/-2.4 microM, n = 3). Histamine stimulated intracellular Ca2+ ([Ca2+]i) mobilization in CEPI-17-CL4 cells with a potency of 6.3+/-1.5 microM (n=4). The histamine-induced [Ca2+]i mobilization was reduced by about 28% following pre-incubation of the cells with 4 mM EGTA. While triprolidine completely inhibited histamine-induced [Ca2+]i mobilization, it did not influence the bradykinin-induced [Ca2+]i mobilization response. Histamine (EC50s = 1.28-2.77 microM, n=3-4) concentration-dependently stimulated the release of interleukin-6 (IL-6), IL-8 and granulocyte macrophage colony-stimulating factor, but it did not significantly alter release of tumour necrosis factor-alpha, PGE2 or collagenase-1 (matrix metalloproteinase-1; MMP-1) from CEPI cells. However, IL-1 (10 ng ml(-1)), foetal bovine serum (10%) and phorbol-12-myristate-13-acetate (3 microg ml(-1)) were effective positive control secretagogues of all the cytokines, PGE2 and MMP-1, respectively, from these cells. It is concluded that the CEPI cells express H1-histamine receptors which are positively coupled to PI turnover and [Ca2+]i mobilization which may be directly or indirectly responsible for the release of various cytokines from these cells at physiologically and/or pathologically relevant concentrations.     

A three-stage damage detection method for large-scale space structures using forward substructuring approach and enhanced bat optimization algorithm

In this study, an efficient three-stage method is proposed for damage detection of large-scale space structures by employing forward substructuring approach, modal strain energy and enhanced bat algorithm (EBA) optimization. EBA is a modified version of BA that is proposed in this paper and used a passive congregation operator to improve the performance of standard BA. In the first stage, the global structure is divided into manageable substructures. The stiffness matrices of independent substructures are obtained based on Kron’s substructuring method. Then a modal strain energy-based index is employed to precisely locate the eventual damages of the structure. In the third stage, damage severities are estimated via EBA using the second-stage results. To demonstrate the ability of the proposed method for detection of multiple structural damages, large-scale space structures with different types of damage scenarios are considered. The results show that the proposed method can detect the exact locations and severity of damages highly accurate in space structures.

     

Adrenal tumors and pregnancy

The lats gene has been identified as a tumour suppressor in Drosophila melanogaster using mosaic screens. Mosaic flies carrying somatic cells that are mutant for lats develop large tumours in many organs. The human LATS1 homologue rescues embryonic lethality and inhibits tumour growth in lats mutant flies, demonstrating the functional conservation of this gene. Biochemical and genetic analyses have revealed that LATS1 functions as a negative regulator of CDC2 (ref. 3). These data suggest that mammalian LATS1 may have a role in tumorigenesis. To elucidate the function of mammalian LATS1, we have generated Lats1-/- mice. Lats1-/- animals exhibit a lack of mammary gland development, infertility and growth retardation. Accompanying these defects are hyperplastic changes in the pituitary and decreased serum hormone levels. The reproductive hormone defects of Lats1-/- mice are reminiscent of isolated LH-hypogonadotropic hypogonadism and corpus luteum insufficiency in humans. Furthermore, Lats1-/- mice develop soft-tissue sarcomas and ovarian stromal cell tumours and are highly sensitive to carcinogenic treatments. Our data demonstrate a role for Lats1 in mammalian tumorigenesis and specific endocrine dysfunction.     

Multiple Workflow Scheduling Strategies with User Run Time Estimates on a Grid

In this paper, we present an experimental study of deterministic non-preemptive multiple workflow scheduling strategies on a Grid. We distinguish twenty five strategies depending on the type and amount of information they require. We analyze scheduling strategies that consist of two and four stages: labeling, adaptive allocation, prioritization, and parallel machine scheduling. We apply these strategies in the context of executing the Cybershake, Epigenomics, Genome, Inspiral, LIGO, Montage, and SIPHT workflows applications. In order to provide performance comparison, we performed a joint analysis considering three metrics. A case study is given and corresponding results indicate that well known DAG scheduling algorithms designed for single DAG and single machine settings are not well suited for Grid scheduling scenarios, where user run time estimates are available. We show that the proposed new strategies outperform other strategies in terms of approximation factor, mean critical path waiting time, and critical path slowdown. The robustness of these strategies is also discussed.     

An efficient facet shell element for corotational nonlinear analysis of thin and moderately thick laminated composite structures

In the present work, an efficient facet shell element for the geometrically nonlinear analysis of laminated composite structures using the corotational approach is developed. The facet element is developed by combining the discrete Kirchhoff-Mindlin triangular bending element (DKMT), and the optimal membrane triangular element (OPT). The membrane-bending coupling effect of composite laminates is incorporated in the formulation, and inconsistent stress stiffness matrix is formulated. Using corotational formulation and the proposed facet element, some example laminated composite structures with geometric nonlinearity are analyzed, and the results are compared with those found using other facet elements.     

A Launch-time Scheduling Heuristics for Parallel Applications on Wide Area Grids

Large and dynamic computational Grids, generally known as wide-area Grids, are characterized by a large availability, heterogene- ity on computational resources, and high vari- ability on their status during the time. Such Grid infrastructures require appropriate schedule mechanisms in order to satisfy the application performance requirements (QoS). In this paper we propose a launch-time heuristics to schedule component-based parallel applications on such kind of Grid. The goal of the proposed heuristics is threefold: to meet the minimal task computation- al requirement, to maximize the throughput between communicating tasks, and to evaluate on-the-fly the resource availability to minimize the aging effect on the resources state. We evaluate the proposed heuristics by simulations applying it to a suite of task graphs and Grid platforms randomly generated. Moreover, a further test was conducted to schedule a real application on a real Grid. Experimental results shown that the proposed solution can be a viable one.     

Report of the Third Workshop on the Usage of NetFlow/IPFIX in Network Management

The Network Management Research Group (NMRG) organized in 2010 the Third Workshop on the Usage of NetFlow/IPFIX in Network Management, as part of the 78th IETF Meeting in Maastricht. Yearly organized since 2007, the workshop is an opportunity for people from both academia and industry to discuss the latest developments of the protocol, possibilities for new applications, and practical experiences. This report summarizes the presentations and the main conclusions of the workshop.