Quantitative determinations of phenol and resorcinol in pharmaceutical dosage forms by high-pressure liquid chromatography

The quantitative determinations of phenol in phenolated calamine lotion USP and of phenol and resorcinol in phenol-resorcinol-boric acid solution by high-pressure liquid chromatography are reported. The procedures are simple, rapid (no special preliminary treatment is required), and accurate. There is no interference from other ingredients of the lotion (bentonite magma, calamine, and zinc oxide) or solution (acetone and boric acid).     

Terminal nitrogen rise

Eighteen-breath nitrogen washouts were performed on eight subjects. Each washout could be simulated by a four-compartment model, each compartment with a different ventilation-to-volume ratio and a variable contribution to expiratory flow. In large breaths initiated near residual volume, a terminal nitrogen rise (TNR) was seen. To account for the TNR with this model, there were relatively small changes in flow from compartments with markedly different nitrogen concentration. Reasons are given for believing these compartments could not be the upper and lower lung. Three of these subjects were studied in the supine, seated, and head-down positions. The TNR was seen at the same lung volume in all positions. At routine bronchospirometry in a second group of subjects, sampling with small catheters during a nitrogen washout showed a TNR in the expirate of lungs, lobes, segments, and subsegments in the upright and supine positions. Apparently a large vertical hydrostatic gradient is unnecessary to produce a TNR. Finally, the TNR was shown to occur at that lung volume where transpulmonary pressure is very small and changing rapidly with volume. This TNR was often followed by a terminal nitrogen fall while the lung was continuing to empty. The TNR occurs when flow from a large poorly ventilated compartment increases relative to the flow from other compartments. A model of lung in which the poorly ventilated compartment develops high specific compliance at low lung volume explains these data.     

Impact properties of thermoplastic composites

The excellent properties exhibited by thermoplastic composites at much reduced weight have attracted attention in the development of products in different sectors. Thermoplastic (TP) composites, because of their distinctive properties as well as ease of manufacturing, have emerged as a competitor against the conventional thermoset resin-based composites. Depending on the application, these composites may undergo impact events at various velocities and often fail in many complex modes. Hence, the development of TP composites having high energy-dissipation at (the desired) much-reduced weight has become a challenging task, but it is a problem which may be alleviated through the appropriate selection of materials and fabrication processes. Furthermore, fibre surface modification has been shown to increase fibre-matrix interfacial adhesion, which can lead to improved impact resistance. Textile preforms are helpful in acting as a structural backbone in the composites since they offer a relatively free hand to the composite designer to tailor its properties to suit a specific application. Additionally, hybrid textile composite structures may help in achieving the desired properties at much lower weight.

Simulation software can play a significant role in the evaluation of composites without damaging physical samples. Once the simulation result has been validated with actual experimental results, it should be possible to predict the test outcomes for different composites, with different characteristics, at different energy levels without conducting further physical tests. Various numerical models have been developed which have to be incorporated into these software tools for better prediction of the result.

In the current issue of Textile Progress, the effects of various materials and test parameters on impact behaviour are critically analyzed. The effect of incorporating high-performance fibres and natural fibres or their hybrid combination on the impact properties of TP composites are also discussed and the essential properties of TP polymers are briefly explained. The effects of fibre and matrix hybridization, environmental factors, various textile preform structures and fibre surface modification treatments on the impact properties of thermoplastic composites are examined in detail. Various numerical models used for impact analysis are discussed and the potential applications of TP composites in automobile, aerospace and medical sectors are highlighted.     

Study on thermal resistance of multilayered fabrics under different compressional loads

In this work, the thermal resistance of multilayered fabric ensembles meant for cold weather conditions were studied under different compressional loads. An instrument has been developed to study the thermal resistance of fabrics under different compressional loads. The instrument consists of a test plate, guard plates and a bottom plate. The test plate and guard plates were assembled together as a single entity, which can be moved up and down with a screw shaft. A load cell was connected to the plate assembly to apply the required compressional load on the fabric specimen. Thermal resistance of multilayered fabrics was studied in the developed instrument under different loading conditions. Single-jersey knitted fabric, needle punched fabric and polytetraflouroethylene (PTFE) coated fabrics were used in the inner, middle and outer layer, respectively. Twenty different multilayered fabric ensembles with the same inner and outer layers were studied. The middle layers, i.e. needle punched nonwoven fabrics, were produced from polyester hollow fibres, with varying linear density of fibre, mass per unit area and punch density. The thermal resistance of multilayered fabrics obtained from the developed instrument was compared with the thermal resistance of instruments, namely sweating guarded hot plate (SGHP) and Alambeta. Regression equations were developed and the contour plots were drawn to analyse the effect of the fibre, fabric and process parameters. ANOVAs were conducted to find the significance of the compressional load, linear density of fibre, mass per unit area and punch density on the thermal resistance of fabrics. It was found that the thermal resistance obtained from the instrument follows the same trend as that of thermal resistance obtained from SGHP and Alambeta. Mass per unit area was found to have significant effect on the thermal resistance of multilayered fabrics under different compressional loads. The effect of punch density decreases with the increase in compressional load on the thermal resistance of multilayered fabrics. The thermal conductivity of multilayered fabrics was observed to increase with the increase in the compressional load.     

Modelling of yarn shrinkage due to washing

Yarn shrinkage due to washing is modelled using the idea of helical model of yarn. The derived theoretical relation between yarn shrinkage and yarn twist intensity is experimentally verified. It is proved that yarn shrinkage increases non-linearly with the increase in yarn twist intensity.     

Packing of micro-porous yarns: Part I. Optimization of yarn characteristics

The present paper deals with the factors affecting the packing of a micro-porous yarn, namely proportion of PVA fibre content, yarn twist multiplier (TM) and spindle speed at ring frame, and with their combined effect on various properties of the yarn. The micro-pores within the structure of the yarn have been created by dissolving the PVA fibres using washing treatment in hot water. A three-variable factorial design technique proposed by Box and Behnken is used to investigate the combined interaction effect of the above variables on the properties of the yarn. The present experiment variables, namely proportion of PVA fibre, yarn twist multiplier (TM) and spindle speed, were found to have significant impact on various properties of yarns before and after wash. For yarns before wash, the specific volume reduces with the increase in the PVA content, yarn twist and spindle speed. In the case of yarns after wash, there is reduction in the yarn specific volume with the increase in TM and spindle speed, but with the increase in the PVA percentage the yarn specific volume increases. The tenacity of yarns before wash increases with the increase in the PVA content, but for yarns after wash, the proportion of PVA content has comparatively less influence. The compressibility of yarns before wash reduces with the increase in the PVA content, but a reverse trend is observed in the case of yarns after wash. The design variables were optimized for all the yarn properties by using the response surface equations.     

Production of Vegetable Protein from Rapeseed Press-Cake Using Response Surface Methodology,Weighted Multivariate Index,and Desirability Function: A Way to Handle Correlated Multiple Responses

The majority of present day industrial processes/products are defined by several quality characteristics, for which the process variables need to be precisely modulated to meet the required specifications. Hence, the multi-response process optimization has become an increasingly important and demanding task. In practice, many of these quality characteristics under consideration show conflicts among themselves, which need to be simultaneously satisfied. This situation is aggravated when the quality characteristics show correlation. To remedy this shortfall, we present a novel multi-objective process optimization approach, based on weighted principal components (principal component scores weighted by their respective eigen values), response surface methodology and desirability function. The implementation of the suggested approach is presented on a study that discusses the optimization of light-colored and reduced phytate containing protein extraction process from rapeseed press-cake. The effectiveness of the said approach was confirmed by performing additional confirmatory experiments at the predicted optimal condition. Furthermore, this study suggests the feasibility of the exploitation of the waste oilseed cake for extraction of high quality vegetable protein, using viable process and simple computational procedure. This study also briefly highlights performance analyses in cross-flow batch extraction scheme using optimized condition.