Hypothyroidism due to ectopy in siblings

Two families each had two siblings with hypothyroidism due to ectopy and hypoplasia of the thyroid. A genetic factor controlling normal thyroid development and descent may be responsible, and the importance of plasma thyroid-stimulating hormone estimation in borderline hypothyroid cases is emphasized. We suggest screening of siblings of patients with ectopic thyroid for hypothyroidism.     

Observation of two-dimensional steady-state photorefractivescreening solitons

The first observation of two-dimensional steady-state photorefractive solitons is reported. Application of an electric field of 5.8 kV/cm to strontium barium niobate yields solitons with diameters as small as 9.6 μm at microwatt power levels     

Tight Bounds for Unconditional Authentication Protocols in the Manual Channel and Shared Key Models

We address the message authentication problem in two seemingly different communication models. In the first model, the sender and receiver are connected by an insecure channel and by a low-bandwidth auxiliary channel, that enables the sender to ldquomanuallyrdquo authenticate one short message to the receiver (for example, by typing a short string or comparing two short strings). We consider this model in a setting where no computational assumptions are made, and prove that for any there exists a -round protocol for authenticating -bit messages, in which only bits are manually authenticated, and any adversary (even computationally unbounded) has probability of at most to cheat the receiver into accepting a fraudulent message. Moreover, we develop a proof technique showing that our protocol is essentially optimal by providing a lower bound of on the required length of the manually authenticated string. The second model we consider is the traditional message authentication model. In this model, the sender and the receiver share a short secret key; however, they are connected only by an insecure channel. We apply the proof technique above to obtain a lower bound of on the required Shannon entropy of the shared key. This settles an open question posed by Gemmell and Naor (Advances in Cryptology-CRYPTO '93, pp. 355-367, 1993). Finally, we prove that one-way functions are necessary (and sufficient) for the existence of protocols breaking the above lower bounds in the computational setting.     

A Gel‐Based Model of Selective Cell Motility: Implications for Cell Sorting,Diagnostics, and Screening

The ability to precisely control cell‐loaded material systems is essential for in vitro testing of novel therapeutics poised to advance to clinic. In this report, unique patterns of cell migration are devised into an in vitro gel‐in‐gel model for the purpose of obtaining cell response data to potentially therapeutic chemical agonists. The model consists of co‐cultures in a cell‐loaded microgel invading an acellular “sorting” gel. Material properties including biophysical and chemical compositions of the sorting gel are carefully controlled to guide a desired cell‐specific behavior, leading to massive tumor cell invasion by amoeboid migration mechanisms. Optical transparency enables straightforward and high‐throughput measurements of outgrowth response in the presence of either chemical and photoradiation therapy. Important dosing and drug sensitivity information are obtained with the gel‐in‐gel model using no more than a light microscope, without further need for arduous genomic or proteomic screening of the tissue samples.     

Ion channel stochasticity may be critical in determining the reliability and precision of spike timing

The firing reliability and precision of an isopotential membrane patch consisting of a realistically large number of ion channels is investigated using a stochastic Hodgkin-Huxley (HH) model. In sharp contrast to the deterministic HH model, the biophysically inspired stochastic model reproduces qualitatively the different reliability and precision characteristics of spike firing in response to DC and fluctuating current input in neocortical neurons, as reported by Mainen & Sejnowski (1995). For DC inputs, spike timing is highly unreliable; the reliability and precision are significantly increased for fluctuating current input. This behavior is critically determined by the relatively small number of excitable channels that are opened near threshold for spike firing rather than by the total number of channels that exist in the membrane patch. Channel fluctuations, together with the inherent bistability in the HH equations, give rise to three additional experimentally observed phenomena: subthreshold oscillations in the membrane voltage for DC input, "spontaneous" spikes for subthreshold inputs, and "missing" spikes for suprathreshold inputs. We suggest that the noise inherent in the operation of ion channels enables neurons to act as "smart" encoders. Slowly varying, uncorrelated inputs are coded with low reliability and accuracy and, hence, the information about such inputs is encoded almost exclusively by the spike rate. On the other hand, correlated presynaptic activity produces sharp fluctuations in the input to the postsynaptic cell, which are then encoded with high reliability and accuracy. In this case, information about the input exists in the exact timing of the spikes. We conclude that channel stochasticity should be considered in realistic models of neurons.     

Scanning superconducting quantum interference device on a tip for magnetic imaging of nanoscale phenomena

We describe a new type of scanning probe microscope based on a superconducting quantum interference device (SQUID) that resides on the apex of a sharp tip. The SQUID-on-tip is glued to a quartz tuning fork which allows scanning at a tip-sample separation of a few nm. The magnetic flux sensitivity of the SQUID is 1.8 μΦ(0)/Hz and the spatial resolution is about 200 nm, which can be further improved. This combination of high sensitivity, spatial resolution, bandwidth, and the very close proximity to the sample provides a powerful tool for study of dynamic magnetic phenomena on the nanoscale. The potential of the SQUID-on-tip microscope is demonstrated by imaging of the vortex lattice and of the local ac magnetic response in superconductors.     

An Optimally Fair Coin Toss

We address one of the foundational problems in cryptography: the bias of coin-flipping protocols. Coin-flipping protocols allow mutually distrustful parties to generate a common unbiased random bit, guaranteeing that even if one of the parties is malicious, it cannot significantly bias the output of the honest party. A classical result by Cleve (Proceedings of the 18th annual ACM symposium on theory of computing, pp 364–369, 1986) showed that for any two-party \(r\)-round coin-flipping protocol there exists an efficient adversary that can bias the output of the honest party by \(\varOmega (1/r)\). However, the best previously known protocol only guarantees \(O(1/\sqrt{r})\) bias, and the question of whether Cleve’s bound is tight has remained open for more than 20 years. In this paper, we establish the optimal trade-off between the round complexity and the bias of two-party coin-flipping protocols. Under standard assumptions (the existence of oblivious transfer), we show that Cleve’s lower bound is tight: We construct an \(r\)-round protocol with bias \(O(1/r)\).     

Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications

At present, there is an unprecedented level of interest in the properties and structures of complexes consisting of DNA mixed with oppositely charged cationic liposomes (CLs). The interest arises because the complexes mimic natural viruses as chemical carriers of DNA into cells in worldwide human gene therapy clinical trials. However, since our understanding of the mechanisms of action of CL-DNA complexes interacting with cells remains poor, significant additional insights and discoveries will be required before the development of efficient chemical carriers suitable for long-term therapeutic applications. Recent studies describe synchrotron X-ray diffraction, which has revealed the liquid crystalline nature of CL-DNA complexes, and three-dimensional laser-scanning confocal microscopy, which reveals CL-DNA pathways and interactions with cells. The importance of the liquid crystalline structures in biological function is revealed in the application of these modern techniques in combination with functional transfection efficiency measurements, which shows that the mechanism of gene release from complexes in the cell cytoplasm is dependent on their precise liquid crystalline nature and the physical and chemical parameters (for example, the membrane charge density) of the complexes. In [section sign] 5, we describe some recent new results aimed at developing bionanotube vectors for gene delivery.     

Phason dynamics in nonlinear photonic quasicrystals

We study the dynamics of phasons in a nonlinear photonic quasicrystal. The photonic quasicrystal is formed by optical induction, and its dynamics is initiated by allowing the light waves inducing the quasicrystal to nonlinearly interact with one another. We show quantitatively that, when phason strain is introduced in a controlled manner, it relaxes through the nonlinear interactions within the photonic quasicrystal. We establish experimentally that the relaxation rate of phason strain in the quasicrystal is substantially lower than the relaxation rate of phonon strain, as predicted for atomic quasicrystals. Finally, we monitor and identify individual 'atomic-scale' phason flips occurring in the photonic quasicrystal as its phason strain relaxes, as well as noise-induced phason fluctuations.     

Localisation of light in disordered lattices

A short review of the basic concepts underlying localisation of light through multiple scattering in disordered media is provided, in conjunction with the ideas related to the universal features occurring during transport of waves and Anderson localisation. Progress in the area is described, including the recent experimental observation of localisation in photonic lattices upon which random perturbations are superimposed, which has constituted the first observation of Anderson localisation in any perturbed periodic system. Subsequently, some of the new intriguing concepts in the field of localisation of light are discussed, among them the combination of nonlinearity and disorder, and their effects on waves transport. Finally, being somewhat speculative, future directions in the area and their potential impact on the basic understanding of the universal phenomena associated with transport of waves are suggested.