Structural and physical properties of silk fibroin/alginate blend sponges

Silk fibroin/alginate blend sponges were examined through IR spectroscopy, X‐ray diffractometry, and differential scanning calorimetry to determine the structural changes of silk fibroin. The effects of fibroin/alginate blend ratios on the physical and mechanical properties were investigated to discover the feasibility of using these blend sponges as biomedical materials such as wound dressings. The compressive modulus of silk fibroin was increased up to 30 kPa, from 7.1 kPa, by blending with alginate. Thermal crystallization behavior of fibroin induced by heat treatment was restricted by blending with alginate. In spite of that, the structural characteristics of fibroin were not changed by incorporation with alginate. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2174–2179, 2004     

Rheological characterization of chitosan matrices: Influence of biopolymer concentration

Viscoelastic properties of chitosan (CH), chitosan‐poly(ethylene glycol) 400 (CH‐PEG), and chitosan‐poly(ethylene glycol) 400 with glyoxal as crosslinking agent (CH‐PEG‐Gly) systems were studied to analyze the effect of chitosan concentration (from 0.83 to 1.67%). Dynamic moduli increase as chitosan concentration increases for all systems. For CH and CH‐PEG systems the loss modulus (G″) is greater than the storage modulus (G′) with predominance of the viscous over the elastic behavior. This corresponds to the characteristic behavior of solutions (nonstructured systems). The presence of PEG 400 induces a complementary reinforcement of the mechanical properties of the system. Except for the lowest chitosan concentration, when glyoxal was added to the CH‐PEG systems, a gelled matrix was obtained. In this case, G′ is greater than G″, and practically independent of frequency. This behavior is typical of three‐dimensional networks and indicates true gel formation, showing clear elastic behavior (tan δ < 1). In creep and recovery analysis, CH‐PEG‐Gly systems exhibited distinct regions that were mathematically modeled using Burger's model. This analysis shows that the CH‐PEG‐Gly matrices (from 1.25 to 1.67%) recover almost totally (100%). Therefore, these matrices could be useful as systems for the development of films for topical hydrophilic drug delivery, and the levels of the residual viscosity (η₀) or the complex viscosity (η*) could be used to control drug release. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007     

Effects of log position in the stem and commercial thinning on jack pine chip dimensions produced by a chipper-canter

Fifteen stems of jack pine (Pinus banksiana Lamb.) coming from three commercial thinned (CT) plots (control, moderate, and intensive thinning) in the Abitibi-Témiscamingue region, Canada, were cross-cut into three 2.4 m length sections: bottom, middle, and top logs. Logs were processed with a chipper-canter at three cutting widths (CW 12.7, 19.1, and 25.4 mm), producing chips and a three faced cant. Chips were assessed by thickness, width, and length. Knot characteristics [total knot number (TKN) and area (TKA)] were assessed in the three cant faces. Growth ring attributes [earlywood density, latewood density (LWD), ring density (RD), earlywood proportion (EWP), ring width, and rings per mm], mechanical properties (shear, splitting, modulus of elasticity and modulus of rupture in bending), and basic density were evaluated on samples obtained within each CW area. The weighted mean chip thickness (WCT) was significantly affected by the log position in the stem (LPS) and CW. WCT increased as CW increased. Jack pine produce thicker chips than black spruce, when processed under the same cutting parameters. Thickness of chips coming from bottom and middle logs was similar due to a greater taper of the bottom log, which slightly increased this dimension. Thickest chips were produced in the top log due to a higher TKA and TKN towards the top of the stem. Multiple linear regressions showed that TKA, CW, and RD were significant predictors of WCT. Chip size distributions were significantly affected by the CT, LPS, and CW. Thinned stands logs appeared to produce smaller chips than natural stand logs. Moreover, chip thickness distribution was affected primarily by TKA and EWP, while the width and length distribution was mainly affected by EWP, LWD, and TKN. Chip size in jack pine is to some degree determined by knot attributes, growth ring characteristics, and wood density of the raw material. These results suggest the potential advantage of sorting logs prior to chipping, either by species, LPS and/or provenance (thinned or natural stands).     

Unexpected effect of the vehicle (grain ethanol) of homeopathic FSH on the in vitro survival and development of isolated ovine preantral follicles

The aims of this study were to investigate the effects of medium replacement system (experiment I) and of FSH presentations (homeopathic – FSH 6cH and allopathic FSH – rFSH; experiment II) on the in vitro development, hormone production and gene expression of isolated ovine preantral follicles cultured for 6 days. In experiment I, secondary follicles were cultured in the α‐MEM⁺ supplemented with FSH 6cH (0.05 fg/ml) or recombinant bovine FSH (100 ng/ml) without/with daily medium addition. The homeopathic FSH treatments with/without medium addition improved (p < .05) follicular development compared to rFSH100 treatment without addition. FSH 6cH with addition showed the highest (p < .05) estradiol production. To verify whether the effects of homeopathic FSH were not due to its vehicle, experiment II was performed. The α‐MEM⁺ was supplemented or not with alcohol (0.2% grain ethanol, v/v), FSH 6cH or rFSH100 with daily medium addition. Surprisingly, we found that all treatments improved follicular development compared to the α‐MEM⁺ (p < .05). Moreover, homeopathic FSH was similar to the other treatments including its vehicle. In conclusion, its vehicle (ethanol) causes the effect of homeopathic FSH on in vitro development of isolated ovine preantral follicles.     

Microparticles of α-Bi2O3 Obtained from Bismuth Basic Nitrate [Bi6O6(OH)2(NO3)4·2H2O] with Photocatalytic Properties

Topics in Catalysis - Alpha phase bismuth oxide (α-Bi2O3) microparticles were prepared through the annealing at 600&nbsp;°C of basic bismuth nitrate [Bi6O6(OH)2(NO3)4·2H2O]...     

Recent Advances in Radiometals for Combined Imaging and Therapy in Cancer

Nuclear medicine is defined as the use of radionuclides for diagnostic and therapeutic applications. The imaging modalities positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are based on γ-emissions of specific energies. The therapeutic technologies are based on β⁻-particle-, α-particle-, and Auger electron emitters. In oncology, PET and SPECT are used to detect cancer lesions, to determine dosimetry, and to monitor therapy effectiveness. In contrast, radiotherapy is designed to irreparably damage tumor cells in order to eradicate or control the disease‘s progression. Radiometals are being explored for the development of diagnostic and therapeutic radiopharmaceuticals. Strategies that combine both modalities (diagnostic and therapeutic), referred to as theranostics, are promising candidates for clinical applications. This review provides an overview of the basic concepts behind therapeutic and diagnostic radiopharmaceuticals and their significance in contemporary oncology. Select radiometals that significantly impact current and upcoming cancer treatment strategies are grouped as clinically suitable theranostics pairs. The most important physical and chemical properties are discussed. Standard production methods and current radionuclide availability are provided to indicate whether a cost-efficient use in a clinical routine is feasible. Recent preclinical and clinical developments and outline perspectives for the radiometals are highlighted in each section.     

Capillary zone electrophoresis in nonaqueous solvents in the presence of ionic additives

Capillary zone electrophoresis (CZE) in nonaqueous media and in the presence of ionic additives has been successfully applied to the determination of compounds that differ only slightly in their electrophoretic mobilities. Triazine herbicides of environmental interest were chosen as test compounds because they behave as very weak bases. CZE separation of these analytes (especially chlorotriazines) in aqueous solution is difficult due to the low pH required for their conversion into protonated cationic form (HA(+)). However, in mixed nonaqueous solvents, 50% (v/v) acetonitrile-methanol, the acid-base characteristics of these compounds are modified, yielding the protonated ionic species that is susceptible to migration when subjected to an electric field. A noteworthy increase in separation selectivity and resolution can be achieved by using ionic additives. Thus, in this mode of capillary zone electrophoresis, separation is based on ionic interactions between the charged analytes and the ionic additive present in the separation medium. These interactions contribute to enhancing mobility differences and to improving analyte separation. For the separation of chloro- and methylthiotriazines, 10 mM perchloric acid in 50% (v/v) acetonitrile-methanol and 20 mM SDS proved to be satisfactory, providing high resolution in short analysis times. The selectivity achieved was found to depend on the degree of association of the analyte with the ionic additive in the nonaqueous medium. This permits manipulation of the selectivity of the electrophoretic separations as a function of the type and concentration of the ionic additive and of the nature of the nonaqueous medium employed.     

Use of post-column fluorescence derivatization to develop a liquid chromatographic assay for ranitidine and its metabolites in biological fluids

OBJECTIVE: To describe the cytologic features of solid and cystic tumor of the pancreas. STUDY DESIGN: Cytologic features of four cases of solid and cystic tumor of the pancreas (SCT) were reported and compared with those of three cases of islet cell tumor of the pancreas. RESULTS: Aspiration and imprint cytology of the tumor cells obtained from three cases of SCT showed papillary structures or rosette formations in part and demonstrated uniformly round to oval nuclei that contained finely granular chromatin, a fairly distinct nucleolus and a scant to moderate amount of granular or vesicular cytoplasm. Another case of SCT consisted of multinucleated giant cells with coherent chromatin as well as mononuclear cells with nuclear grooves. Islet cell tumor consisted mainly of clustered or isolated uniform mononuclear cells with rosette formations but without a papillary structure and occasional multinucleated giant cells in all cases. The nuclei of islet cell tumors had peculiar, fine chromatin aggregates with a "salt-and-pepper" appearance and slightly enlarged nucleoli. CONCLUSION: SCT is cytologically distinguishable from islet cell tumor in spite of having many cytologic features in common with it.     

Thermal and Tribological Properties of <Emphasis Type="Italic">Jatropha</Emphasis> Oil as Additive in Commercial Oil

The recent use that has been given to bio-oil as an additive, in a commercial engine oil, raises the necessity to study its physical properties. The present study is aimed to obtain thermal properties of blends made with Jatropha-Curcas L. Oil, Crude, and Refined, at different concentrations using SAE40W oil (EO) as a lubricant base. By using photothermal techniques, thermal effusivity and diffusivity were obtained. The obtained results show that thermal effusivity increases from 455 \(\hbox {Ws}^{1/2}{\cdot }\hbox {m}^{-2}{\cdot }\hbox {K}^{-1}\) to 520 \(\hbox {Ws}^{1/2}{\cdot }\hbox {m}^{-2}{\cdot }\hbox {K}^{-1}\) as the percentage of additive increases as well, whereas thermal diffusivity values range from \(7\times 10^{-8}\hbox {m}^{2}{\cdot }\hbox {s}^{-1}\) to \(10\times 10^{-8}\hbox {m}^{2}{\cdot }\hbox {s}^{-1}\). In the present study, four balls test was used in order to obtain friction coefficient and wear scar values for studied samples, the obtained results point out that in general refined Jatropha-Curcas L. oil presents smaller wear scars than the crude one.     

Low-cost disordered carbons for Li/S batteries: A high-performance carbon with dual porosity derived from cherry pits

A micro- and mesoporous carbon obtained from cherry pit waste and activated with H₃PO₄ acid has been studied as the sulfur host for Li/S batteries. The carbon has a high specific surface area of 1,662 m²·g^–1 (SBET) and micropore and mesopore volumes of 0.57 and 0.40 cm³·g^–1, respectively. The S/C composite, with a sulfur content of 57% deposited by the disproportionate reaction of a S₂O₃ ^2? solution in an acid medium without an additional heating step above the S melting point, delivers an initial specific capacity of 1,148 mAh·g^–1 at a current of C/16. It also has a high capacity retention of 915 mAh·g^–1 after 100 cycles and a Coulombic efficiency close to 100%. The good performance of the composite was also observed under higher current rates and long-term cycling tests. The capacities delivered by the cell after 200 cycles were 707 and 410 mAh·g^–1 at C/2 and 1C (1C = 1,675 mA·g^–1), respectively, maintaining the high Coulombic efficiency. The overall electrochemical response of this carbon as the sulfur matrix is among the best reported so far among the other biomass-derived carbons, probably because of the micro- and mesopore system formed upon activation.

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