Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus

Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients.     

Cr2O3 nanoparticles: A promising candidate to improve the mechanical properties and corrosion resistance of Ni-Co alloy coatings

This study was aimed to assess the effects of reinforcement nanoparticles content, on the microstructural features, mechanical properties, and corrosion-related properties of Ni-Co-Cr₂O₃ nanocomposite coatings. Scanning electron microscope (SEM), energy dispersive X-ray spectrometer (EDS), and X-ray diffraction (XRD) analysis were employed in order to evaluate the microstructural features and chemical composition of the nanocomposites. Moreover, the microhardness tester and electrochemical impedance spectra (EIS) tests coupled with potentiodynamic polarization measurements were used to investigate the mechanical and corrosion-related properties, respectively. Results demonstrate that albeit the volume fraction of cobalt in coating, average particle size, Cr₂O₃ nanoparticle content in coating, and microstructural features are of prime significance in determining the mentioned properties of the nanocomposite coatings, Co content is more important. Actually, Cr₂O₃ nanoparticles serve as suitable nucleation sites for Co particles deposition throughout the microstructure. Thus, combined actions of Cr₂O₃ nanoparticles incorporation and their optimal content ensures the nucleation of high population of Co particles, which significantly contributes to the improvement in the properties. The Ni-Co-8.9 wt%Cr₂O₃ nanocomposite coating exhibits the superior mechanical and corrosion-related properties.     

Extending Fault-Based Testing to Microelectromechanical Systems

As stable fabrication processes for MicroElectroMechanical Systems (MEMS) emerge, research efforts shift towards the design of systems of increasing complexity. The ways in which testing is going to be performed for large volume complex devices embedding MEMS are not known. As in the microelectronics industry, the development of cost-effective tests for larger systems may well require test stimuli targeting actual faults, developing fault lists and fault models for realistic manufacturing defects and failure modes, and using fault simulation as a major approach for assessing testability and dependability. In this paper, we illustrate how fault-based testing can be extended to MEMS, both for bulk and surface micromachining technologies, making possible the reuse of analog testing techniques.     

Provision of distance learning services over Interactive Digital TV with MHP

E-learning technologies have developed greatly in recent years, with considerable success. However, there is increasing evidence that web-based learning is not reaching the social sectors which are more reluctant to contact with the new technologies, thus leading to inequalities in the access to education and knowledge in the Information Society. By hiding the intricacies of computers behind the familiarity of household equipment, Interactive Digital TV (IDTV) is considered to play a key role in addressing this problem, and the term t-learning has been recently coined to mean TV-based interactive learning.     

Thermal and mechanical properties of polyurethane rigid foam/modified nanosilica composite

Surface modification of fumed nanosilica was performed by using n‐(2‐aminoethyl)‐3‐aminopropyltrimethoxysilane as a coupling agent. Then, modified nanosilica was utilized in the preparation of polyurethane rigid foam. The characterization and the study of properties were done by some techniques, such as Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic mechanical analysis, and thermomechanical analysis. Also, tensile test was examined to evaluate the static mechanical properties. With the increasing of modified nanosilica, thermal and static mechanical properties were enhanced, but dynamic mechanical behavior was different from static mechanical behavior because of the different properties of interfacial domain and bulk matrix. The presence of functional groups on the nanosilica surface affected stoichiometry and reduced hard phase formation in bulk polymer. The decrease in glass transition temperature (T_g) confirmed this statement. POLYM. ENG. SCI., 2010. © 2009 Society of Plastics Engineers     

Application of titanium oxide nanotube films containing gold nanoparticles for the electroanalytical determination of ascorbic acid

Au/TiO₂/Ti electrodes have been prepared by galvanic deposition of gold particles on TiO₂ nanotube substrates. Titanium oxide nanotubes are fabricated by anodizing titanium foil in a Dimethyl Sulfoxide electrolyte containing fluoride. The scanning electron microscopy results indicated that gold particles are homogeneously deposited on the surface of TiO₂ nanotubes. The TiO₂ layers consist of individual tubes of about 40-80 nm diameters. The electro-catalytic behavior of Au/TiO₂/Ti and flat gold electrodes for the ascorbic acid electro-oxidation was studied by cyclic voltammetry. The results showed that the flat gold electrode is not suitable for the oxidation of ascorbic acid. However, the Au/TiO₂/Ti electrodes are shown to possess catalytic activity toward the oxidation reaction. Catalytic oxidation peak current showed a linear dependence on the ascorbic acid concentration and a linear calibration curve is obtained in the concentration range of 1-5 mM of ascorbic acid. Also, determination of ascorbic acid in real samples was evaluated. The obtained results were found to be satisfactory. Finally the effects of interference on the detection of ascorbic acid were investigated.     

A multiobjective integrated multiproject scheduling and multiskilled workforce assignment model considering learning effect under uncertainty

Today, organizations try to decline academically expenses using humans and resources in addition to rising managers and operators' satisfaction. Meantime, a very important step in the process of decision is the assignment of human resources, particularly in connection with research and development (R&D) projects in which the system is highly dependent on the capabilities of human resources. In this study, we tried all the assumptions that come true in the real world, considered a model for applied R&D projects to reduce costs and increase the efficiency of projects. Therefore, an integrated multiproject scheduling and multiskill human resource assignment model under uncertainty has developed for R&D projects. Furthermore, it is assumed that the activity processing time is related to human resources assignment that means the learning effect is considered. To demonstrate the proposed model efficiency, the various dimensions instance problem was solved accurately and efficiently in GAMS software, and the results have been reported. In addition, the proposed model is validated through the input parameter sensitivity analysis. The results indicate a suitable performance of the proposed fuzzy mathematical programming model is due to the complexity of the problem.     

Texture features’ based classification of MR images of normal and herniated intervertebral discs

Multimedia Tools and Applications - Disc herniation is considered as a very common spine abnormality resulting in severe pain in back and legs. Besides it has great impact on economy of suffering...