Optimal power control system of a research nuclear reactor

The power control system is a key control system for a nuclear reactor, which directly concerns the safe operation of a nuclear reactor. Much attention is paid to the power control system performance of nuclear reactor in engineering. The designers put a high value upon design of an optimal power control system. In this paper, a design method is applied to the design of power control system. According to the optimal control theory, an objective function, quadratic performance index with weight factors is proposed. Then, the objective function is transformed into frequency domain form by use of Paserval's theorem. In frequency domain, an optimal transfer function can be obtained at the lowest value of objective function. The system with optimal transfer function has an optimal performance. The transfer function of the power control system is derived from a typical research nuclear reactor. Using the state feedback theory, the transfer function is synthesized to the optimal transfer function. The simulative results with the optimal controller and with a conventional controller show that the performance of the optimal power control system is largely improved on dynamic characters. The method applied here not only can be used for research nuclear reactor but also can be easily extended to pressurized water reactor power plant and other fields.     

The effect of pitch and collimation on radiation dose in spiral CT

1 Introduction Spiral computed tomography (CT) was intro- duced in clinical practice in 1980s. Its distinctive characteristic is continuous data acquisition and con- tinuous tube rotation with high speed while simulta- neously translating the patient through the gantry.[1] Owing to these functions the spiral CT possesses the ability to scan an entire organ volume within a single breathhold. Thus, the anatomical section is contiguous and therefore the reliable demonstration of small le- sions…     

Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response,Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inflammation and accelerated aging, we test the hypothesis whether maternal obesity induces aging processes in the developing liver and determines thereby hepatic growth. To this end, maternal obesity was induced with high-fat diet (HFD) in C57BL/6N mice and male offspring were studied at the end of the lactation [postnatal day 21 (P21)]. Maternal obesity induced an obese body composition with metabolic inflammation and a marked hepatic growth restriction in the male offspring at P21. Proteomic and molecular analyses revealed three interrelated mechanisms that might account for the impaired hepatic growth pattern, indicating prematurely induced aging processes: (1) Increased DNA damage response (γH2AX), (2) significant upregulation of hepatocellular senescence markers (Cdnk1a, Cdkn2a); and (3) inhibition of hepatic insulin/insulin-like growth factor (IGF)-1-AKT-p38-FoxO1 signaling with an insufficient proliferative growth response. In conclusion, our murine data demonstrate that perinatal obesity induces an obese body composition in male offspring with hepatic growth restriction through a possible premature hepatic aging that is indicated by a pathologic sequence of inflammation, DNA damage, senescence, and signs of a possibly insufficient regenerative capacity.     

Limited Accuracy of Pan-Trk Immunohistochemistry Screening for NTRK Rearrangements in Follicular-Derived Thyroid Carcinoma

Patients with advanced thyroid cancer harboring NTRK rearrangements can be treated with highly effective selective inhibitors. Immunohistochemistry (IHC) analysis, to detect Trk protein expression, represents an appealing screening strategy for NTRK rearrangements, but its efficacy has been poorly explored in thyroid cancer. The aim of this study is to investigate the diagnostic utility of Trk IHC in the identification of NTRK rearrangements. A series of 26 follicular-derived thyroid tumors, positive for NTRK rearrangements, and 28 NTRK fusion-negative controls were retrospectively analyzed by IHC using the pan-Trk monoclonal antibody (clone {"type":"entrez-protein","attrs":{"text":"EPR17341","term_id":"523383444","term_text":"EPR17341"}}EPR17341) on the Ventana system. Area under the curve (AUC), sensitivity and specificity were calculated by ROC analysis. Trk expression was detected in 25 samples, including 22 out of the 26 NTRK-rearranged (84.6%) and three out of 28 NTRK-negative samples (10.7%). Four out of twenty-six NTRK-rearranged thyroid tumors were negative for Trk expression (15.4%), all carrying the ETV6/NTRK3 fusion. The AUC, sensitivity and specificity were 0.87, 0.85 and 0.89, respectively. A screening based on IHC analysis showed limited sensitivity and specificity in the identification of NTRK-rearranged tumors. Since falsely negative results could preclude the administration of effective targeted drugs, alternative detection strategies should be considered for thyroid cancer.     

Acute T-Cell-Driven Inflammation Requires the Endoglycosidase Heparanase-1 from Multiple Cell Types

It has been accepted for decades that T lymphocytes and metastasising tumour cells traverse basement membranes (BM) by deploying a battery of degradative enzymes, particularly proteases. However, since many redundant proteases can solubilise BM it has been difficult to prove that proteases aid cell migration, particularly in vivo. Recent studies also suggest that other mechanisms allow BM passage of cells. To resolve this issue we exploited heparanase-1 (HPSE-1), the only endoglycosidase in mammals that digests heparan sulfate (HS), a major constituent of BM. Initially we examined the effect of HPSE-1 deficiency on a well-characterised adoptive transfer model of T-cell-mediated inflammation. We found that total elimination of HPSE-1 from this system resulted in a drastic reduction in tissue injury and loss of target HS. Subsequent studies showed that the source of HPSE-1 in the transferred T cells was predominantly activated CD4⁺ T cells. Based on bone marrow chimeras, two cellular sources of HPSE-1 were identified in T cell recipients, one being haematopoiesis dependent and the other radiation resistant. Collectively our findings unequivocally demonstrate that an acute T-cell-initiated inflammatory response is HPSE-1 dependent and is reliant on HPSE-1 from at least three different cell types.     

Structural dynamic displacement vision system using digital image processing

This study introduces dynamic displacement vision system (DDVS), which is applicable for imaging unapproachable structures using a hand-held digital video camcorder and is more economical than the existing contact and contactless measurement methods of dynamic displacement and deformation. This proposed DDVS method is applied to the Region of Interest (ROI) resizing and coefficient updating at each time step to improve the accuracy of the measurement from the digital image. Thus, after evaluating the algorithms conducted in this study by the static and dynamic verification, the measurement's usability by calculating the dynamic displacement of the masonry specimen, and the two-story steel frame specimen is evaluated under uniaxial seismic loading. The algorithm of the proposed method in this study, despite the relatively low resolution during frozen, slow, and seismic motions, has precision and usability that can replace the existing displacement transducer. Moreover, the method can be effectively applied to even fast behavior for multi-measurement positions like the seismic simulation test using large scale specimen. DDVS, using the consecutive images of the structures with an economic, hand-held digital video camcorder is a more economical displacement sensing concept than the existing contact and contactless measurement methods.     

Indoor residual spray and insecticide-treated bednets for malaria control: theoretical synergisms and antagonisms

Indoor residual spray (IRS) of insecticides and insecticide-treated bednets (ITNs) are the two most important malaria vector control tools in the tropical world. Application of both tools in the same locations is being implemented for malaria control in endemic and epidemic Africa. The two tools are assumed to have synergistic benefits in reducing malaria transmission because they both act at multiple stages of the transmission cycle. However, this assumption has not been rigorously examined, empirically or theoretically. Using mathematical modelling, we obtained the conditions for which a combination strategy can be expected to improve upon single control tools. Specifically, spraying of dichlorodiphenyltrichloroethane (DDT) in all houses where residents are not using ITNs can reduce transmission of malaria (R₀) by up to 10 times more than the reduction achieved through ITNs alone. Importantly, however, we also show how antagonism between control tools can arise via interference of their modes of action. Repellent IRS reduces the likelihood that ITNs are contacted within sprayed houses and ITNs reduce the rate at which blood-fed mosquitoes rest on sprayed walls. For example, 80 per cent coverage of ITNs and DDT used together at the household level resulted in an R₀ of 11.1 when compared with an R₀ of 0.1 achieved with 80 per cent ITN coverage without DDT. While this undesired effect can be avoided using low-repellence pyrethroid chemicals for IRS, the extent of the potential benefits is also attenuated. We discuss the impact that this result will likely have on future efforts in malaria control combination strategy.     

A theoretical and experimental investigation of the tool-tip vibration and its influence upon surface generation in single-point diamond turning

This paper presents a theoretical and experimental investigation of the influence of tool-tip vibration on surface generation in single point diamond turning (SPDT). Although it is well known that the relative vibration between the tool and the workpiece plays an important role in the surface generation in single-point diamond turning, most of the prior work has been focused on studying the relative tool-work vibration in the infeed (thrust force) direction while the significant contribution of the effect of the tool-tip vibration in the cutting force direction has been overlooked. In the present study, two characteristic peaks (twin peaks) are identified and found to be corresponding to the tool-tip vibrations by power spectrum density (PSD) analyses. The vibrations possess the features of small amplitude but high frequency. A physical model is proposed to capture the dominant factor based on the characteristic and it reveals that the twin peaks are attributed by the impact between the tool tip and workpiece and the process damping effect. Hence, a geometric model of surface roughness is proposed to take account of tool-tip vibration and it is verified through a series of experiments. The simulation results have been found to agree well with the experimental results.     

A 1-V 100-MS/s 8-bit CMOS Switched-Opamp Pipelined ADC Using Loading-Free Architecture

A 1-V, 8-bit pipelined ADC is realized using multi-phase switched-opamp (SO) technique. A novel loading-free architecture is proposed to reduce the capacitive loading and to improve the speed in low-voltage SO circuits. Employing the proposed loading-free pipelined ADC architecture together with double-sampling technique and a fast-wake-up dual-input-dual-output switchable opamp, the ADC achieves 100-MS/s conversion rate, which to our knowledge is the fastest ADC ever reported at 1-V supply using SO technique, with performance comparable to that of many high-voltage switched-capacitor (SC) ADCs. Implemented in a 0.18-mum CMOS process, the ADC obtains a peak SNR of 45.2 dB, SNDR of 41.5 dB, and SFDR of 52.6 dB. Measured DNL and INL are 0.5 LSB and 1.1 LSB, respectively. The chip dissipates only 30 mW from a 1-V supply