A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine

1. The effects of histamine on gastric mucosal blood flow in the presence and absence of gastric acid secretion were studied in the rat. 2. Histamine, in doses greater than those required to stimulate maximal acid secretion, caused a small increase in mucosal blood flow per unit acid output. 3. When acid secretion was inhibited by methyl analogues of prostaglandin E2, histamine reduced arterial blood pressure and gave a dose dependent rise in mucosal blood flow. 4. When acid secretion was inhibited by the histamine H2-receptor antagonists, burimamide and metiamide, histamine still increased mucosal blood flow. 5. The use of H1-receptor antagonists to inhibit the histamine-induced hyperaemia was made difficult by their vasodilator actions. 6. The selective histamine H2-receptor agonist, 4-methyl histamine, had no effect on arterial blood pressure in doses which stimulated acid secretion. The increase in mucosal blood flow which accompanied the stimulation of acid secretion was inhibited by the anti-secretory prostaglandins and H2-receptor antagonists. 7. The selective histamine H1-receptor agonist, 2-pyridyl ethylamine, had no effect on acid output but increased resting mucosal blood flow. 8. These results suggest that histamine H2-receptors, primarily concerned with acid secretion, and H1-receptors concerned with vasodilatation are both present in the rat gastric mucosa.     

Vibration of Tensioned Beams with Intermediate Damper. I: Formulation, Influence of Damper Location

Exact analytical solutions are formulated for free vibrations of tensioned beams with an intermediate viscous damper. The dynamic stiffness method is used in the problem formulation, and characteristic equations are obtained for both clamped and pinned supports. The complex eigenfrequencies form loci in the complex plane that originate at the undamped eigenfrequencies and terminate at the eigenfrequencies of the fully locked system, in which the damper acts as an intermediate pin support. The fully locked eigenfrequencies exhibit “curve veering,” in which adjacent eigenfrequencies approach and then veer apart as the damper passes a node of an undamped mode shape. Consideration of the evolution of the eigenfrequency loci with varying damper location reveals three distinct regimes of behavior, which prevail from the taut-string limit to the case of a beam without tension. The second regime corresponds to damper locations near the first antinode of a given undamped mode shape; in this regime, the loci bend backwards to intersect the imaginary axis, and two distinct nonoscillatory decaying solutions emerge when the damper coefficient exceeds a critical value.     

Vibration of Tensioned Beams with Intermediate Damper. II: Damper near a Support

Analytical solutions are used to investigate the free vibrations of tensioned beams with a viscous damper attached transversely near a support. This problem is of particular relevance for stay-cable vibration suppression, but no restrictions on the level of axial load are introduced, and the results are quite broadly applicable. Characteristic equations for both clamped and pinned supports are rearranged into forms suitable for numerical solution by fixed-point iteration, whereby the complex eigenfrequencies and corresponding damping ratios can be accurately computed within a few iterations. Explicit asymptotic approximations for the complex eigenfrequencies are also obtained, subject to restrictions on the closeness of the eigenfrequencies to their undamped values. These asymptotic approximations are expressed in the same “universal” form identified in previous studies. It is observed that the maximum attainable modal damping ratios and the corresponding optimal values of the damper coefficient can be significantly affected by bending stiffness and by the nature of the support conditions, and a nondimensional parameter grouping is identified that enables an assessment of when bending stiffness should be considered.     

Children's understanding of the knowledge prerequisites of drawing and pretending.

Many young children will claim that someone is pretending to be something even when the person does not know what that something is. To examine whether children's failure to take knowledge prerequisites into account is part of a more fundamental problem in recognizing how mental representations constrain external ones, the authors asked children whether an artist who did not know what something was, yet whose drawing bore resemblance to it, was drawing it. The same questions were asked regarding pretending. Children performed similarly on pretending and drawing questions, and performance on both questions improved when the protagonists' point of view was emphasized. Performance for drawing improved somewhat when alternative goals were stated. Further, cross-sectional data indicated that understanding how knowledge relates to producing external representations increases gradually from age 4 to age 8, suggesting that experiential factors may be crucial to this understanding. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Photophobia and phonophobia in migraineurs between attacks

This study investigated whether migraineurs are more sensitive to light and sound while headache-free than are healthy people. Fifty-two migraineurs (mean age 39 years) were selected using the International Headache Society diagnostic criteria for migraine. Forty-eight healthy controls were matched for age, sex, and race (mean age 36 years). Visual and auditory discomfort thresholds were measured by exposing subjects to increasing light and sound until they complained of discomfort. There were significant differences between groups in both the light discomfort threshold (P < 0.00005) and the hearing discomfort threshold (P < 0.0005). The thresholds for both were lower in the migraineurs. Overall, for both groups together, there was a significant negative correlation between light discomfort threshold and age (correlation coefficient -0.2276, P = 0.011), but not for the hearing discomfort threshold and age (P = 0.275). The results show that the migraineurs were significantly more sensitive to light and sound when headache-free than were healthy controls. The apparent increased intolerance to light in both groups together noted with increased age, did not apply to the migraine group.     

Structural Modeling of Inflated Foam-Rigidized Aerospace Structures

An ideal aerospace structure would be inexpensive, a convenient size and weight for launch, easily deployed, and provide necessary stiffness∕performance. This paper examines one type of potentially inexpensive, easily deployed space structure: the inflated foam-rigidized structure. Research aimed at gaining insight into the construction and structural characteristics of foam-rigidized inflated aerospace structures is presented in this paper. Sample foam-rigidized struts were fabricated using a two-part commercially available closed-cell polyurethane foam that was injected in a controlled fashion into a cylindrical Kapton shell. These struts were tested nondestructively to evaluate bending behavior and destructively to examine material characteristics. Testing of the foam-rigidized struts indicates that significant variations of material properties should be expected when injecting polyurethane foam into a single spot and allowing it to expand to fill a structure. An analytical model of the bending behavior of foam-rigidized inflated struts is also presented and compared with experimental bending data.     

The effect of a strong magnetic field on the damping of second sound in dilute3He-4He mixtures below 100 mK

We have measured the increase in damping of second sound in 0.1% and 0.05%³He-⁴He solutions upon application of a magnetic field of 10 T. The increase is caused by changes in the thermal conductivity and viscosity of the mixture as the system becomes spin polarized. We show how to fit the data for the viscosity in zero-field to obtain an estimate of the interaction between the³He quasiparticles. It is then possible to predict the viscosity in a field of 10 T using the calculation of Hampson et al. The data agree with the theory to within 2%.     

Human immunodeficiency virus seroprevalence in community-based primary care practices, 1990-1992. A report from the Ambulatory Sentinel Practice Network

OBJECTIVE: To estimate the seroprevalence of human immunodeficiency virus type 1 (HIV-1) infection in primary care practices. METHODS: Fifty-four practices in the United States participated in an anonymous, unlinked HIV seroprevalence study between January 1990 and December 1992. Residual blood samples drawn for routine clinical tests from patients 15 to 49 years of age were centrally tested for the HIV-1 antibody for 1 month of each quarter. Information about patient demographics, clinician-recognized risk factors, the known HIV status of the patient, and whether the blood was drawn for HIV testing was recorded with each specimen. RESULTS: Of 21,998 specimens collected, 99 (0.45%) were seropositive. Of these 99 seropositive persons, 31.3% (a seroprevalence of 0.15%) were not suspected by their clinicians of being infected with HIV. Seroprevalences in men (0.96%) exceeded those in women (0.22%), and rates in rural practices (0.18%) were lower than in urban practices (0.71%). Among patients with unsuspected HIV infection, however, the gender differences, especially in rural areas, were less pronounced. Risk factors for HIV infection were infrequently noted. There was an increase in the overall seroprevalence during the 1990 to 1992 study period (0.36% to 0.53%); however, this trend was not statistically significant. CONCLUSIONS: Within a 3-year period, clinicians in at least two of five primary care practices can expect to encounter patients infected with HIV, regardless of practice location. Also, nearly one third of the patients with HIV infection will not be suspected of having this condition by their clinician.     

Mothers' attachment status as determined by the Adult Attachment Interview predicts their 6-year-olds' reunion responses: A study conducted in Japan.

Following a 1986 study reporting a predominance of ambivalent attachment among insecure Sapporo infants, the generalizability of attachment theory and methodologies to Japanese samples has been questioned. In this 2nd study of Sapporo mother-child dyads (N=43), the authors examined attachment distributions for both (a) child, based on M. Main and J. Cassidy's (1988) 6th-year reunion, and (b) adult, via the Adult Attachment Interview (AAI). In contrast to the previous Sapporo study, children's 3-way or "organized" distribution did not differ from the global distribution. However, when the disorganized-controlling (D) and cannot classify (CC) categories were applied to the analyses, a high proportion of D/CC children was found. Comparable analyses for Japanese mothers, including the unresolved/disorganized (U) and CC categories, were found to deviate slightly from the global norm. However, turning from global distributions to mothers' AAI classification as related to their child's reunion classification, all matches were surprisingly close to those established worldwide. When, as is customary, mothers' U and CC classifications were combined (U/CC) and compared with the child's D and CC classifications (also customarily combined as D/CC), mothers' U/CC status strongly predicted child D/CC status (r=.60, d=1.50). Additionally, mothers' AAI subclassifications predicted child subclassifications. (PsycINFO Database Record (c) 2010 APA, all rights reserved)