Three-dimensional reconstruction of microcalcification clustersfrom two mammographic views

Classification of benign/malignant microcalcification clusters is a major diagnostic challenge for radiologists. Clinical studies have revealed that the shape of the cluster, and the spatial distribution of individual microcalcifications within it, are important indicators of its malignancy. However, mammographic images of clustered microcalcifications confound their three-dimensional (3-D) distribution with image projection and breast compression. This paper presents a novel model-based method for reconstructing microcalcification clusters in 3-D from two mammographic views (cranio-caudal and medio-lateral oblique--"shoulder to the opposite hip" or lateral-medio). We develop a 3-D breast representation and a parameterised breast compression model which constraints geometrically the possible 3-D positions of a calcification in a two-dimensional image. Corresponding calcifications in the two views are matched using an estimate of the calcification volume. Both the geometric constraint and the matching criterion are utilized in the final reconstruction step to build the 3-D reconstructed clusters. Validation experiments are described using 30 clusters to verify the individual steps of the model, and results consistent with known ground truth are obtained. Some of the approximations in the model and future work are discussed in the concluding section.     

Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy

The Japanese black bear, Ursus thibetanus japonicus, is a seasonal breeder and shows delayed implantation for several months during pregnancy. The objective of this study was to clarify the steroidogenic capability of the corpus luteum and placenta during pregnancy, including both delayed implantation and fetal development, by immunolocalization of steroidogenic enzymes in these organs of the Japanese black bear. Ovaries and placentae from 15 wild Japanese black bears, which had been killed legally by hunters and were thought to be pregnant, were used in an immunocytochemical study to localize the cholesterol side chain cleavage cytochrome P450 (P450scc), 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17alpha-hydroxylase cytochrome P450 (P450c17) and aromatase cytochrome P450 (P450arom) by the avidin-biotin-peroxidase complex method using polyclonal antisera raised in mammals against P450scc, 3betaHSD, P450c17 and P450arom. P450scc and 3betaHSD were localized in all luteal cells throughout pregnancy. P450c17 was present in a few luteal cells, especially in the outer area of the corpus luteum throughout pregnancy, but the number of positively immunostained cells decreased during the post-implantation period. Cells positively immunostained for P450c17 were significantly smaller than negatively immunostained cells (P < 0.01). P450arom was present sporadically in a few luteal cells throughout pregnancy, but the number of positively immunostained cells decreased during the post-implantation period. The size of cells positively immunostained for P450arom was not significantly different from that of negatively immunostained cells. The whole placenta was negatively immunostained for P450scc, 3betaHSD and P450c17, but P450arom was present in the syncytiotrophoblasts and endothelial cells of maternal blood vessels. These results indicate that, in the Japanese black bear, corpora lutea are a source of progesterone which may play an important role in the maintenance of delayed implantation and fetal development during pregnancy. Corpora lutea have a minimum capability to synthesize androgen in small luteal cells and oestrogen in normal-sized luteal cells during pregnancy, and placentae have the ability to synthesize oestrogen during late pregnancy.     

Rapid production of β-FeSi2 by spark-plasma sintering

Thermoelectric materials of Fe_0.91Mn_0.09Si₂ were produced with two methods (i.e., hot pressing (HP) and spark-plasma sintering (SPS)) and their thermoelectric properties were compared. The relative density of the samples sintered at the same temperature for thirty minutes was similar. The relative density of the SPS specimen reached 90% in five minutes at 1173 K, while the HP specimen reached 90% in thirty minutes at 1173 K. The optimum condition of the heat treatment was found to be for 3.6 ks at 943 K for the transformation to the -phase. The peritectoid reaction ( + ) mainly occurred at and above 953 K, and the eutectoid reaction mainly occurred at 943 K. The -phase ratio of the HP specimen was larger than that of the SPS specimen because the peritectoid reaction occurred during longer cooling period from 1173 K to 943 K. Consequently, the Seebeck coefficient of the SPS specimen was slightly smaller than that of the HP specimen. However, the figure of merit was very similar because the thermal conductivity of the SPS specimen was smaller than that of the HP specimen. Thus, the SPS method is superior to the HP method with respect to mass-production because the production time is significantly shorter.     

自组织InAs/GaAs量子点的表面氮化研究

用低温光荧光(PL)和透射电子显微镜(TEM)研究了表面氮化自组织InAs/GaAs量子点的光学性能和微观结构。结果表明氮化后形成薄层的InAsN薄膜作为应变缓和层覆盖在量子点的表面,使得随着氮化时间的增加,InAs量子点的位错密度提高、尺寸变大、纵横比提高、发光波长变长、强度变低。     

Effects of Broadband Laser Generated Ultrasound on Array Gain

Array gain is a common parameter used in laser phased array research. This paper will present a new parameter called the frequency modulation of laser phased array (FMLPA). The array gain model for laser phased arrays was derived using an assumption that ultrasound from each array member interferes with each other. This would be always true if laser generated ultrasound is narrow band. However, laser generation of ultrasound is broad band. Broad band ultrasound signals have short duration in the time domain. If the time delay between generated wave fronts from each array member is longer than the duration of the broad band ultrasound signal from each array member, the ultrasound signals from each array member will not interfere with each other. The time delay between generated wave fronts from each array member is 0 s at a laser phased array’s beam steering angle and increases away from the beam steering angle. Therefore, ultrasound from each array member always interfere at angles close to the beam steering angle. However, ultrasound from each array member may not interfere at angles away from the beam steering angle depending on the time delay between generated wave fronts and duration of the broad band ultrasound signal. A theoretical model of the FMLPA was developed and experimentally verified for use when ultrasound from each array member does not interfere with each other. It was experimentally verified that current array gain equations still apply when ultrasound from array members interfere with each other. The FMLPA can be used to create new techniques for measuring weld penetration depth, crack location, and dimensions of objects.     

Color displays and flexible displays using quick‐response liquid‐powder technology for electronic paper

Abstract— Color displays and flexible displays that use electronic liquid powder have been developed. Novel types of color displays using either a colored powder or a color filter are discussed. We have also developed a flexible display with low‐cost substrate films with a high‐throughput roll‐to‐roll manufacturing method. These technologies enable a QR‐LPD to be widely used as an electronic‐paper display.     

A hybrid method for detecting the onset of local necking by monitoring the bulge forming load

Strain-based Forming Limit Diagrams (FLD), which are typically obtained under linear or quasi-linear loading conditions, describe the limiting strains in terms of the major and minor in-plane strains before the onset of necking or the final failure (FFD). These strains can be detected by analysing the strain field in the vicinity of necking or cracking defects. It has generally been agreed that the loading versus time signal is not suitable for detecting necking processes. A novel hybrid method of detecting the onset of necking based on the experimental and simulated bulging load is presented in this paper. This method consists mainly in comparing the experimental forming load, i.e., a load showing plastic instability, with the numerical predictions obtained by performing finite element simulation. The simulation of the bulging process does not include any damage or failure criteria. A homogeneous forming load can therefore be simulated without requiring any information about the localization. This method was applied to detecting the onset of local necking in circular and elliptic quasistatic bulge tests on sheet material, with a diameter of 200 mm. Two materials were tested, a 0.8 mm thick DP450 Dual Phase steel sheet and a 1 mm thick AA6016-T4 aluminium sheet. The onset of necking observed with our method was compared with the results obtained by performing Hogström’s analysis based on the measured strain field over time and similar necking strains were obtained. Beside, the Bressian Williams Hill (BWH) shear criterion was identified for each test from experimental results. A slight scattering of the shear stress values was observed.     

Challenges in the capture and dissemination of measurements from high-speed networks

The production of a large-scale monitoring system for a high-speed network leads to a number of challenges. These challenges are not purely technical but also socio-political and legal. The number of stakeholders in such monitoring activity is large including the network operators, the users, the equipment manufacturers and, of course, the monitoring researchers. The MASTS project (measurement at all scales in time and space) was created to instrument the high-speed JANET lightpath network and has been extended to incorporate other paths supported by JANET(UK). Challenges the project has faced included: simple access to the network; legal issues involved in the storage and dissemination of the captured information, which may be personal; the volume of data captured and the rate at which these data appear at store. To this end, the MASTS system will have established four monitoring points each capturing packets on a high-speed link. Traffic header data will be continuously collected, anonymised, indexed, stored and made available to the research community. A legal framework for the capture and storage of network measurement data has been developed which allows the anonymised IP traces to be used for research purposes.     

High-temperature pyrolysis of ceramic fibers derived from polycarbosilane–polymethylhydrosiloxane polymer blends with porous structures

The polymer blends of PCS (polycarbosilane) and PMHS-h (polymethylohydrosiloxane with high molecular weight) were prepared by freeze-drying process of mixed benzene solution. Melt viscosity, mass loss, and gas evolution from prepared polymer blends were analyzed. A polymer blend of HSah15 (15 mass% PMHS-h to PCS) was melt-spun to fiber form, curing by thermal oxidation and pyrolyzed at various temperatures up to 1773 K. The obtained fibers were investigated by tensile tests, FE-SEM (field emission scanning electron microscope) observation, and XRD (X-ray diffraction) analysis. After pyrolysis at 1273 K, there were no pores in the cross section of the fiber derived from pure PCS; however, there were amounts of pores in the cross sections of the fiber derived from HSah15. After pyrolysis at 1773 K, the coarse β-SiC (silicon carbide) crystals were formed on the outside surface of the fiber derived from pure PCS; however, no remarkable β-SiC crystal were formed on the outside surface of the fiber derived from HSah15.