Daniel Crístian Ferreira Soares  Andreza de Sousa Andrada  Gilson Andrade Ramaldes 《Particulate Science and Technology》2013,31(4):331-338

Today, cancer represents one of the main causes of death worldwide, making it a formidable challenge for all scientific areas that seek new therapeutic approaches for its cure. As a therapeutic approach, radiotherapy, widely used in treating various types of tumors, acts by not discriminating healthy cells from tumor cells. Seeking to minimize these effects, nanostructured carriers of radioisotopes have been studied with the aim of improving the specificity of action of ionizing radiation, delivering and retaining adequate amounts of radioactive isotopes within tumor cells, leading them to death. In the present work, silica nanoparticles were prepared in order to evaluate their capacity to act as a nanocarrier of the ¹⁵⁹Gd-DTPA-BMA radioactive complex, which can selectively deliver high radiation doses to tumors. Furthermore, this formulation seeks to prevent nontarget tissues from receiving excessive amounts of radiation, acting as a new potential alternative to conventional radiotherapy, in which a large dose of radiation is delivered to nontarget tissues, causing harm to healthy surrounding tissues.  相似文献   

    

Eduardo M. R. Fairbairn  Iuri A. Ferreira  Guilherme C. Cordeiro  Marcos M. Silvoso  Romildo D. Toledo Filho  Fernando L. B. Ribeiro 《Materials and Structures》2010,43(8):1061-1074

Cement production gives rise to CO₂ emissions generated by the calcination of CaCO₃ and by the combustion of fossil fuels, being responsible for about 5% of the global CO₂ emissions. These emissions can be substantially reduced if cement replacement materials are used. In this paper two residual ashes that can be used as mineral additions are considered: sugar cane bagasse ash and rice husk ash. A case study of the construction of a dam with a blended material composed by cement and these two ashes is presented, indicating the potentiality of its use for civil engineering applications. The analyses were performed using experimental and numerical tools developed on the basis of a thermo-chemo-mechanical model. This model considers the coupling, within the theory of thermodynamics, of the several phenomena that intervene in the hydration process, namely, exothermicity, thermo-activation, chemo-plasticity, evolution of thermal and mechanical properties with the hydration reaction, which includes creep and relaxation.  相似文献   

    

Matteo Mannini  Francesco Pineider  Philippe Sainctavit  Loïc Joly  Arantxa Fraile‐Rodríguez  Marie‐Anne Arrio  Christophe Cartier dit Moulin  Wolfgang Wernsdorfer  Andrea Cornia  Dante Gatteschi  Roberta Sessoli 《Advanced materials (Deerfield Beach, Fla.)》2009,21(2):167-171

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Talita Moreira de Oliveira  Nilda de Fátima Ferreira Soares  Rodrigo Magela Pereira  Kátia de Freitas Fraga 《Packaging Technology and Science》2007,20(2):147-153

Conservation of food products depends on product quality and packaging suitability. The objective of this work was to develop and evaluate the antimicrobial efficiency of natamycin‐incorporated film in the production process of Gorgonzola cheese. It aims to optimize the production process and increase shelf‐life and food safety for the consumer. Films with different concentrations of natamycin were produced and tested in Gorgonzola cheeses to evaluate its efficiency against Penicillium roqueforti on the cheese surface. Films with 2 and 4% natamycin presented satisfactory results for fungus inhibition and the amount of natamycin released to the cheese was below that allowed by the legislation. Copyright © 2006 John Wiley & Sons, Ltd.  相似文献   

    

Ana Clarissa dos Santos Pires  Nilda de Ftima Ferreira Soares  Nlio Jos de Andrade  Luís Henrique Mendes da Silva  Geany Peruch Camilloto  Patrícia Campos Bernardes 《Packaging Technology and Science》2008,21(7):375-383

Antimicrobial films were formed by the incorporation of nisin (NI), natamycin (NA) and a combination of both (NI + NA) into cellulose polymer. Film efficacies were evaluated in vitro against Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 15313, Penicillium sp. and Geotrichum sp. The films were also evaluated on sliced mozzarella cheese against moulds and yeasts, Staphylococcus sp. and psychrotrophic bacteria. Mechanical and microscopic properties of the films and the diffusion of the antimicrobial agents from the film to the cheese were also evaluated. Films containing NI showed an antimicrobial effect in vitro against S. aureus and L. monocytogenes, while films containing NA were effective in vitro against Penicillium sp. and Geotrichum sp. By the ninth day of storage at 12 ± 2°C, the count of yeasts and moulds on cheese covered with films containing NA decreased 2 log10 units compared with the count on cheese with control films. NI film did not show an effect against Staphylococcus sp., but it was effective against psychrotrophic bacteria for 6 days of storage of the cheese. The incorporation of antimicrobial compounds decreased the resistance and elongation of the films and caused changes in their molecular conformation. NI diffusion from the films to the cheese was not detected; however, time‐dependent diffusion of NA from the film containing NI + NA was measured. The incorporation of NI and NA together in the films did not show an effect. The film containing NA showed potential for application as active food packaging for sliced mozzarella cheese. Copyright © 2008 John Wiley & Sons, Ltd.  相似文献   

    

J. L. A. Ferreira  J. C. Balthazar  A. P. N. Araujo 《Engineering Failure Analysis》2003,10(6):745-758

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Ricardo N. Carvalho  Marcelo A. C. Ferreira  Marília M. Lima  Dagoberto B. Santos  Ronaldo Barbosa 《国际钢铁研究》2019,90(2)

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RC Ferreira  JR Heckenlively  JH Menkes  JB Bateman 《Canadian Metallurgical Quarterly》1998,105(6):1076-1078

OBJECTIVE: The authors describe new ocular and electroretinographic (ERG) features in Menkes disease. DESIGN: The study design is a case report. PARTICIPANTS: The authors studied two patients with Menkes disease. INTERVENTION: The authors performed complete ophthalmologic and ERG evaluations in both patients. MAIN OUTCOME MEASURES: The parameters used were slit-lamp biomicroscopy and ERG recordings. RESULTS: Aberrant lashes and anterior stromal hypoplasia of the iris are new findings, and profound delays in b-wave implicit time in well-developed photopic responses may be added as new ERG features. CONCLUSIONS: Patients with Menkes disease may have aberrant lashes, anterior stromal hypoplasia, and retinal degeneration.  相似文献   

    

Bigi  Sabrina; De Acetis  Luigi; De Simone  Roberta; Aloe  Luigi; Alleva  Enrico 《Canadian Metallurgical Quarterly》1993,107(2):363

Subcutaneous (sc) administration of capsaicin (50 mg/kg) at Postnatal Days 2 and 5 exerted long-term effects on isolation-induced aggressive behavior of adult mice of the CD-1 strain. Isolated capsaicin-treated mice (scored during a 10-min session) showed the highest frequency and the longest duration of total attacks, attacks, rattling, and offensive upright posture when compared with nonisolated capsaicin-treated Ss and both isolated and nonisolated vehicle control animals. Hypothalamic substance P (SP) was assessed by radioimmunoassay. Capsaicin treatment significantly lowered hypothalamic SP content in both isolated and nonisolated mice. Moreover, individual scores of isolated capsaicin-treated Ss showed a significant correlation between SP depletion and expression of offensive upright posture. Isolation per se was revealed to play an important role in depleting SP from the hypothalamus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

    

CE Ferreira  SG Grossi  AB Novaes  RG Dunford  EJ Feres-Filho 《Canadian Metallurgical Quarterly》1997,17(3):250-259

The aim of this study was to determine the effect of subgingival scaling and root planing on healing of the distal surface of second molars following extraction of third molars. Twenty-eight patients with contralateral erupted third molars and pocket depths greater than or equal to 3 mm on the distal surface of the second molars participated in this study. Measurements of supragingival bacterial plaque, bleeding on probing, pocket depth, and relative attachment level were performed at baseline and 2 months after treatment. Extraction of contralateral third molars was carried out simultaneously. The experimental site received thorough scaling and root planing of the distal surface of the second molar, while the control site received extraction alone. Experimental sites showed significant improvement in all clinical parameters assessed compared to the control sites. In conclusion, periodontal lesions on the distal of second molars can be significantly improved following scaling and root planing after extraction of third molars.  相似文献