Amnestic mild cognitive impairment: Difference of memory profile in subjects who converted or did not convert to Alzheimer's disease.

Episodic long-term, short-term, and implicit memory were investigated in 79 elderly subjects who fulfilled criteria for the amnestic form of mild cognitive impairment (a-MCI; i.e., by having an idiopathic amnestic disorder with absence of impairment in cognitive areas other than memory and without confounding medical or psychiatric conditions) and who developed Alzheimer's disease (AD) after 2 years as well as in 111 subjects affected by a-MCI who did not develop dementia. Results document a memory profile in a-MCI subjects characterized by preserved short-term and implicit memory and extensive impairment of episodic long-term memory. In virtually all episodic memory indexes examined (learning, forgetting, recognition abilities), a-MCI subjects who converted to AD were more severely impaired than were subjects who did not become demented. This memory profile, which closely resembles that exhibited by amnestic patients with bilateral mesial-temporal lobe lesions, confirms a precocious phase in preclinical AD characterized by selective involvement of mesial-temporal areas and worsening of the memory impairment as atrophic changes progress in hippocampal structures. In this context of pervasive episodic memory impairment, tests assessing the free recall of verbal material following a delay interval demonstrated the greater sensitivity to memory deficits of a-MCI subjects who developed AD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Use of Neural Networks for Automatic Classification From High-Resolution Images

The effectiveness of multilayer perceptron (MLP) networks as a tool for the classification of remotely sensed images has been already proven in past years. However, most of the studies consider images characterized by high spatial resolution (around 15-30 m) while a detailed analysis of the performance of this type of classifier on very high resolution images (around 1-2 m) such as those provided by the Quickbird satellite is still lacking. Moreover, the classification problem is normally understood as the classification of a single image while the capabilities of a single network of performing automatic classification and feature extraction over a collection of archived images has not been explored so far. In this paper, besides assessing the performance of MLP for the classification of very high resolution images, we investigate on the generalization capabilities of this type of algorithms with the purpose of using them as a tool for fully automatic classification of collections of satellite images, either at very high or at high-resolution. In particular, applications to urban area monitoring have been addressed     

Valorization of Beef Tallow by Lipase-Catalyzed Interesterification with High Oleic Sunflower Oil

Although beef tallow (BT) has been considered a hard low-trans fat convenient to be used in several bakery applications, it has some undesirable characteristics like fatty acid composition, crystallization behavior, graininess formation and poor plastic range. This work studied the modification of BT by blending at different percentages with high oleic sunflower oil (HOSFO) followed by the enzyme-catalyzed interesterification of the blends. The reduction in the solid fat content achieved by the simple blending was enhanced by the interesterification process, as a result of the increase in the concentration of the diunsaturated monosaturated type triacylglycerols. Interesterification strongly impacted too on the crystallization behavior of the blends, since products showed more homogeneous and regular crystals than the starting mixture. Results show that lipase catalyzed interesterification of BT with HOSFO offers a useful tool for the design of fats with adjustable physicochemical properties, improved with respect to that of the starting fats.     

Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19

Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role in other infection diseases, we investigated if common noncoding and rare coding variants, affecting CCR5, can predispose to severe COVID-19. We combined single nucleotide polymorphisms (SNPs) that met the suggestive significance level (P ≤ 1 × 10⁻⁵) at the 3p21.31 locus in public GWAS datasets (6406 COVID-19 hospitalized patients and 902,088 controls) with gene expression data from 208 lung tissues, Hi-C, and Chip-seq data. Through whole exome sequencing (WES), we explored rare coding variants in 147 severe COVID-19 patients. We identified three SNPs (rs9845542, rs12639314, and rs35951367) associated with severe COVID-19 whose risk alleles correlated with low CCR5 expression in lung tissues. The rs35951367 resided in a CTFC binding site that interacts with CCR5 gene in lung tissues and was confirmed to be associated with severe COVID-19 in two independent datasets. We also identified a rare coding variant (rs34418657) associated with the risk of developing severe COVID-19. Our results suggest a biological role of CCR5 in the progression of COVID-19 as common and rare genetic variants can increase the risk of developing severe COVID-19 by affecting the functions of CCR5.     

Active control of locomotion facilitates nonvisual navigation.

In some navigation tasks, participants are more accurate if they view the environment beforehand. To characterize the benefits associated with visual previews, 32 blindfolded participants were guided along simple paths and asked to walk unassisted to a specified destination (e.g., the origin). Paths were completed without vision, with or without a visual preview of the environment. Previews did not necessarily improve nonvisual navigation. When previewed landmarks stood near the origin or at off-path locations, they provided little benefit; by contrast, when they specified intermediate destinations (thereby increasing the degree of active control), performance was greatly enhanced. The results suggest that the benefit of a visual preview stems from the information it supplies for actively controlled locomotion. Accuracy in reaching the final destination, however, is strongly contingent upon the destination's location during the preview. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Haptic integration of planar size with hardness, texture, and planar contour.

Three experiments involving a total of 75 college students investigated the role of size information in haptic classification of custom-made planar objects when size covaries with hardness, texture, or planar contour. Exp 1 showed facilitation of classification by redundant (RD) size and shape cues, indicating the coprocessing of size and shape. Exps 2 and 3 used a withdrawal paradigm: Classification trials began with 2 RD properties, and 1 was then held constant (withdrawn). Exp 2 showed that when size and shape were RD, withdrawal of either impaired responses, whereas when size was RD with texture or hardness, only size withdrawal had an effect. Exp 3 demonstrated that this size weighting was not restricted to a single procedure for exploration. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spatial updating of locations specified by 3-D sound and spatial language.

Blind and blindfolded sighted observers were presented with auditory stimuli specifying target locations. The stimulus was either sound from a loudspeaker or spatial language (e.g., "2 o'clock, 16 ft"). On each trial, an observer attempted to walk to the target location along a direct or indirect path. The ability to mentally keep track of the target location without concurrent perceptual information about it (spatial updating) was assessed in terms of the separation between the stopping points for the 2 paths. Updating performance was very nearly the same for the 2 modalities, indicating that once an internal representation of a location has been determined, subsequent updating performance is nearly independent of the modality used to specify the representation. (PsycINFO Database Record (c) 2011 APA, all rights reserved)