Peptidyl Virus-Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells

The self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP-7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP-7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.     

PLC控制在转炉上的应用案例

介绍荣信钢铁转炉过程控制系统的组成、系统功能、技术应用。     

记忆与延续——浅析苏州博物馆与宁波博物馆建筑设计

博物馆建筑,是一个城市文化的象征,如何使博物馆具有文化感,体现传统的审美文化,又具有新的设计元素,引导人类审美意识,苏州博物馆与宁波博物馆做了比较好的探索。     

基于词性的文本挖掘算法在IDS日志中的应用

提出一种以词性为参考值的文本挖掘算法,能有效挖掘与种子词有关的关联规则。基于Bootstrapping算法思想,既减少了预处理阶段对于词根还原的依赖,能处理日志中出现的中文词汇。增加了对于日志文本上下的理解,提高了关联规则的有效性,并应用与IDS日志挖掘之中,有效改善挖掘效率,为规则库提供关联规则。     

A belief-rule-based inventory control method under nonstationary and uncertain demand

This paper is devoted to investigating inventory control problems under nonstationary and uncertain demand. A belief-rule-based inventory control (BRB-IC) method is developed, which can be applied in situations where demand and demand-forecast-error (DFE) do not follow certain stochastic distribution and forecasting demand is given in single-point or interval styles. The method can assist decision-making through a belief-rule structure that can be constructed, initialized and adjusted using both manager’s knowledge and operational data. An extended optimal base stock (EOBS) policy is proved for initializing the belief-rule-base (BRB), and a BRB-IC inference approach with interval inputs is proposed. A numerical example and a case study are examined to demonstrate potential applications of the BRB-IC method. These studies show that the belief-rule-based expert system is flexible and valid for inventory control. The case study also shows that the BRB-IC method can compensate DFE by training BRB using historical demand data for generating reliable ordering policy.     

Spatial interest pixels (SIPs): useful low-level features of visual media data

Visual media data such as an image is the raw data representation for many important applications. Reducing the dimensionality of raw visual media data is desirable since high dimensionality degrades not only the effectiveness but also the efficiency of visual recognition algorithms. We present a comparative study on spatial interest pixels (SIPs), including eight-way (a novel SIP detector), Harris, and Lucas‐Kanade, whose extraction is considered as an important step in reducing the dimensionality of visual media data. With extensive case studies, we have shown the usefulness of SIPs as low-level features of visual media data. A class-preserving dimension reduction algorithm (using GSVD) is applied to further reduce the dimension of feature vectors based on SIPs. The experiments showed its superiority over PCA.

世界城市发展的大生态观与制度制衡

一、生态足迹视野下的四大城市发展弊端加拿大不列颠哥伦比亚大学社区与区域规划学院教授WilliamRees(威廉姆?里斯)2012年3月7日在纽卡斯尔大学建筑规划景观学院发表演讲,提出了"可持续性的障碍是什么?为什么我们如梦游一般走入全球生态危机之中?"的设问。他从生态足迹分析角度,指出了现代城市     

Synthesis of neural tree models by improved breeder genetic programming

Neural tree model has been successfully applied to solving a variety of interesting problems. In most previous studies, optimization of the neural tree model was divided into two steps: first structure optimization, then parameter optimization. One major problem in the evolution of structure without parameter information was noisy fitness evaluation. In this paper, an improved breeder genetic programming algorithm is proposed to the synthesis of neural tree model. The effectiveness and performance of the method are evaluated on time series prediction problems and compared with those of related methods. Simulation results show that the proposed algorithm is a potential method with better performance and effectiveness.     

Accurate mirror-based camera pose estimation with explicit geometric meanings

An accurate closed form solution is proposed to estimate camera pose by several mirrored reference object images acquired via a planar mirror under different unknown poses. Compared with state-of-the-art methods, our method is more accurate when there are more than three images and has explicit geometric meanings. This method also properly handles cases in which some of the mirror poses are parallel. The central idea is to minimize an error metric based on all reflections of rotation, which enables the camera rotation to be estimated directly by SVD of sum of mirrored camera rotations. After that, the camera translation is computed by solving a large system of linear equations to minimize object space collinearity error. Both synthesized data and real data experiments show the advantages of our approach.