INTRODUCTION: Clinical, microbiological, therapeutic and prognostic characteristics of brain abscesses were analyzed as well as the influence of CT in their evolution. MATERIALS AND METHODS: Retrospective study of 59 patients with the diagnosis of brain abscess of bacterial source before (group A) and after (group B) the introduction of CT (25 and 34 patients, respectively). RESULTS: The most common symptom was headache (76.3%) and the most common abnormality in physical examination was a decrease in the level of consciousness (61%) and this abnormality was associated with a higher mortality rate (13% versus 41.6%; p < 0.05) and also a higher proportion of neurologic sequelae (50% versus 85.7%; p < 0.05). The diagnosis was obtained earlier in group B. The hematogenous source predominated (32.2%); an adjacent source was identified in 28.8% and an apparent source was not recognized in 27.2% (40% in group A versus 17.6% in group B). Anaerobic and microaerophilic streptococci were the bacteria recovered most frequently. Gram-negative aerobic bacteria were the most common in otogenic abscesses. The use of corticosteroids had no influence upon mortality, but it was associated with a lower percentage of neurological sequelae (40% versus 14%; p < 0.05). The introduction of CT decreased mortality (40% in group A versus 23.5% in group B, although this difference was not significant) and also sequelae (86.6% in group A versus 57.6% in group B; p < 0.05). Leaving apart cases of bacterial endocarditis, in which death was due to the underlying heart disease and a systemic sepsis picture, mortality attributed to brain abscess was 20.3%. CONCLUSIONS: The introduction of CT has meant a significant breakthrough for the diagnosis, treatment and follow-up of these patients and has contributed to improvement in survival. In our series, the diagnosis of brain abscess was obtained earlier and the number of brain abscesses with no apparent source has decreased since the introduction of CT. Moreover, CT sensitivity is really good for locating multiple abscesses. Overall, the prognosis of these patients has improved since the introduction of this technique. Nevertheless, brain abscess is still associated with a relevant morbi-mortality rate. 相似文献
In October 1995 the World Marrow Donor Association (WMDA) was restructured in order to facilitate its primary function of establishing guidelines in relation to international bone marrow and blood stem cell transplants -- transplants in which the donor is in one country and the patient is in another country. Five new working groups were established -- Donor Registries, Ethics, Quality Assurance, Finances, and Stem Cells. This paper, prepared by members of the Donor Registries Working Group, in consultation with the Quality Assurance Working Group, provides recommendations for the 'donor work-up'. This term covers events that start when the definitive donor has been identified, includes the harvesting (collection) and transportation of the stem cell product and ends when the product reaches the transplant centre. The paper includes examples of the documentation intended to ensure compliance with the recommendations at all key points in the sequence. 相似文献
Unsaponifiable matter from 19 olive and olive pomace oils were studied by high-resolution13C nuclear magnetic resonance spectroscopy. Their spectra showed characteristic peaks that corresponded to molecular substructures
rather than the individual constituents present in the unsaponifiable matter. The presence of squalene and other hydrocarbons,
sterols and triterpenic alcohols, in addition to other groups of minor compounds, were observed. Based on the analysis of
these spectra, it was possible to distinguish among different grades of olive oils by using stepwise discriminant analysis.
This direct method of analysis is suggested to be used in artificial neural networks to define oil identity and quality. 相似文献
Single‐stranded model oligodeoxyribonucleotides, each containing a single protonatable base—cytosine, adenine, guanine, or 5‐methylcytosine—centrally located in a background of non‐protonatable thymine residues, were acid‐titrated in aqueous solution, with UV monitoring. The basicity of the central base was shown to depend on the type of the central base and its nearest neighbours and to rise with increasing oligonucleotide length and decreasing ionic strength of the solution. More complex model oligonucleotides, each containing a centrally located 5‐methylcytosine base, were comparatively evaluated in single‐stranded and double‐stranded form, by UV spectroscopy and high‐field NMR. The N3 protonation of the 5‐methylcytosine moiety in the double‐stranded case occurred at much lower pH, at which the duplex was already experiencing general dissociation, than in the single‐stranded case. The central guanine:5‐methylcytosine base pair remained intact up to this point, possibly due to an unusual alternative protonation on O2 of the 5‐methylcytosine moiety, already taking place at neutral or weakly basic pH, as indicated by UV spectroscopy, thus suggesting that 5‐methylcytosine sites in double‐stranded DNA might be protonated to a significant extent under physiological conditions. 相似文献
Art heritage cities are popular tourist destinations but for many of them overcrowding is becoming an issue. In this paper, we address the problem of modeling and analytically studying the flow of tourists along the narrow alleys of the historic center of a heritage city. We initially present a mean field game model, where both continuous and switching decisional variables are introduced to respectively describe the position of a tourist and the point of interest that he/she may visit. We prove the existence of a mean field equilibrium. A mean field equilibrium is Nash-type equilibrium in the case of infinitely many players. Then, we study an optimization problem for an external controller who aims to induce a suitable mean field equilibrium.
A fundamental and critical problem for Model Reference Adaptive Control (MRAC) systems is the characterisation of the system response during transients. This problem is strictly related to the estimation of the reachable set (RS) from a fixed set of initial conditions and it is typically tackled using the Lyapunov's direct method. One well-known drawback of this approach is the excessive conservatism in the estimation of the RS. To overcome this limitation the authors propose a novel probabilistic framework where uncertain parameters and control signals are considered as random variables. In this framework the RS design is translated into a stochastic convex optimisation problem. This brings the benefit that (probabilistic) LMIs with reduced conservatism can be worked out. The so-called scenario optimisation approach is then used to solve the stochastic optimisation problem with a-priori specified level of reliability. The novel approach is compared with an existing worst-case approach in determining the RS of MRAC systems in the presence of matched and input uncertainty via simulation studies. The proposed methodology can potentially be a useful tool for the probabilistic analysis and design of a broad category of existing adaptive control systems. 相似文献
In this paper, we consider the 0–1 knapsack problem with setups. Items are grouped into families and if any items of a family are packed, this induces a setup cost as well as a setup resource consumption. We introduce a new dynamic programming algorithm that performs much better than a previous dynamic program and turns out to be also a valid alternative to an exact approach based on the use of an Integer Linear Programming (ILP) solver. Then we present a general inapproximability result. Furthermore, we investigate several relevant special cases that still permit fully polynomial‐time approximation schemes and others where the problem remains hard to approximate. 相似文献
This paper investigates the convergence of nonholonomic multiagent coordinate‐free formation control to a prescribed target formation subject to communication delays by means of Lyapunov‐Krasovskii approach and smooth state‐feedback control laws. As a result, an iterative algorithm based on linear matrix inequalities is provided to obtain the worst‐case point‐to‐point delay under which the multiagent system is guaranteed to be stable. It is worth mentioning that: (i) the given algorithm holds for any connected communication topology and (ii) the formation control is coordinate‐free, that is, a common frame is not required to be shared between agents. The effectiveness of the given method is illustrated through simulation results. 相似文献
Consolidation is considered one of the major restoration treatments applied on cultural heritage. This kind of treatment is focused on to preserve the external weathered layers of stone reducing their degradation caused by external alteration agents (mainly water and soluble salts). However the consolidation using commercial products have some limitations, such as: (1) low penetrability; (2) no chemical and mineralogical affinity with the material to treat and (3) release of toxic compounds (VOCs), during the solvent evaporation. In the last years, a new consolidation method based on electrokinetic techniques was developed. This method allows filling some pores by the precipitation of an inorganic compound. As a result the method allows increasing the penetration depth of current consolidation treatments. However, this method needs to be improved since: (1) no special care is taking in controlling the pH of the solutions in contact with the porous material, which can damage it and (2) it is difficult to determine in which area the consolidation takes place. In this study an electrokinetic consolidation method, which has two steps between which the current is reversed, is proposed to solve all of these problems. The results show that the proposed treatment achieves better results in terms of penetrability and durability of current consolidation treatments, and moreover prevent that the treated material to be exposed to extreme pH values. 相似文献