多瑙河之梦 主流笔记本平台秀

在32nm制程Arrandale处理器的帮助下,Intel Calpella平台占据了主流笔记本市场大量份额,作为Intel老对手的AMD自然不会甘心放弃笔记本市场,于2010年第二季度推出针对主流笔记本市场的Danube（多瑙河）平台,凭借一贯以来在性价比上的良好口碑也让消费者对其抱有很大期待。今天,就借华硕K52Dr和海尔简爱7G两款笔记本产品的测试,让我们一同看看AMD Danube（多瑙河）和Intel Calpella两个平台在主流笔记本市场的表现……     

简便 智能——NVIDIA Optimus技术深度体验

推开智能切换的大门 无需用户手动设置和等待即可在后台完成显卡切换动作,且不会对用户产生任何干扰,从而解决传统笔记本双显切换所要面对的屏幕闪烁、切换延迟、中断应用程序等问题,这样的优势让NVIDIA Optimus技术显得十分诱人。当然,笔记本想要支持NVIDIA Optimus技术是需要满足一定条件的,具体可参见下表。     

The organization of interaction design pattern languages alongside the design process

This work explores the possibility of taking the structural characteristics of approaches to interaction design as a basis for the organization of interaction design patterns. The Universal Model of the User Interface (Baxley, 2003) is seen as well suited to this; however, in order to cover the full range of interaction design patterns the model had to be extended slightly. Four existing collections of interaction design patterns have been selected for an analysis in which the patterns have been mapped onto the extended model. The conclusion from this analysis is that the use of the model supports the process of building a pattern language, because it is predictive and helps to complete the language. If several pattern writers were to adopt the model, a new level of synergy could be attained among these pattern efforts. A concluding vision would be that patterns could be transferred freely between pattern collections to make them as complete as possible.     

Child head injury criteria investigation through numerical simulation of real world trauma

Finite element modelling has been used for decades in the study of adult head injury biomechanics and determination of injury criteria. Interest is recently growing in investigation on pediatric head injury which requires elaboration of biofidelic models that take into account child's head particularities in terms of size, geometry, and mechanical properties. In this study, a finite element model of a 3-year-old child head is proposed. The model is reconstructed from real CT scan images and mechanical properties are extracted from available data in the literature. A large number of real accidents (25 falls) are reconstructed with proposed model using different brain constitutive relationships in order to investigate their influence on model response. Mechanical output parameters (HIC, pressure, shearing stress) are calculated from these simulations. Statistical analysis was performed in order to evaluate predictive capability of the parameters. Von Mises stress appears to be clearly the most predictive parameters, allowing clear distinction between injured and non-injured cases. To the authors' knowledge, this study proposes for the first time a statistically based neurological injury criterion for a pediatric population using finite element modelling.     

From I-Awareness to We-Awareness in CSCW

Awareness is one of the central concepts in Computer Supported Cooperative Work, though it has often been used in several different senses. Recently, researchers have begun to provide a clearer conceptualization of awareness that provides concrete guidance for the structuring of empirical studies of awareness and the development of tools to support awareness. Such conceptions, however, do not take into account newer understandings of shared intentionality among cooperating actors that recently have been defined by philosophers and empirically investigated by psychologists and psycho-linguists. These newer conceptions highlight the common ground and socially recursive inference that underwrites cooperative behavior. And it is this inference that is often seamlessly carried out in collocated work, so easy to take for granted and hence overlook, that will require computer support if such work is to be partially automated or carried out at a distance. Ignoring the inferences required in achieving common ground may thus focus a researcher or designer on surface forms of “heeding” that miss the underlying processes of intention shared in and through activity that are critical for cooperation to succeed. Shared intentionality thus provides a basis for reconceptualizing awareness in CSCW research, building on and augmenting existing notions. In this paper, we provide a philosophically grounded conception of awareness based on shared intentionality, demonstrate how it accounts for behavior in an empirical study of two individuals in collocated, tightly-coupled work, and provide implications of this conception for the design of computational systems to support tightly-coupled collaborative work.     

Kernel fisher discriminants for outlier detection

The problem of detecting atypical objects or outliers is one of the classical topics in (robust) statistics. Recently, it has been proposed to address this problem by means of one-class SVM classifiers. The method presented in this letter bridges the gap between kernelized one-class classification and gaussian density estimation in the induced feature space. Having established the exact relation between the two concepts, it is now possible to identify atypical objects by quantifying their deviations from the gaussian model. This model-based formalization of outliers overcomes the main conceptual shortcoming of most one-class approaches, which, in a strict sense, are unable to detect outliers, since the expected fraction of outliers has to be specified in advance. In order to overcome the inherent model selection problem of unsupervised kernel methods, a cross-validated likelihood criterion for selecting all free model parameters is applied. Experiments for detecting atypical objects in image databases effectively demonstrate the applicability of the proposed method in real-world scenarios.     

Reduction of disulfide bonds in an amyloidogenic Bence Jones protein leads to formation of "amyloid-like" fibrils in vitro

Motivated by the finding that the amino acid sequence of the Bence Jones protein BJP-DIA was identical to that of the main protein component of the amyloid fibrils obtained from the same patient with AL-amyloidosis, (Klafki, H.-W., Kratzin, H.-D., Pick, A.-I., Eckart, K., Karas, M. & Hilschmann, N. (1992) Biochemistry 31, 3265-3272.), we attempted to create "amyloid-like" fibrils from the Bence Jones protein in vitro, without addition of proteolytic enzymes. Reduction of BJP-DIA, solubilized in PBS, pH 7.4, overnight at 37 degrees C resulted in the formation of a precipitate which had affinity for the dye Congo red. Electron microscopy of negatively stained samples of the reduced protein revealed aggregates of linear unbranched fibrils. SDS-polyacrylamide gel electrophoresis demonstrated that the precipitate consisted almost exclusively of intact light chain molecules. This result makes it possible to deduce a molecular model of these amyloid fibrils generated in vitro.     

Experimentelle und analytische Untersuchungen zum Zündverhalten stark verdünnter C2H2/O2-Gemische

Zusammenfassung Das Zündverhalten homogener Gasgemische bestehend aus Argon mit C₂H₂+O₂-Anteilen von 2% wird bei ?quivalenzverh?ltnissen von ϕ=0,2; 0,5; 1,0 und 2,0 hinter Sto?wellen experimentell untersucht. Kriterium für das Ende der Induktionsperiode ist das starke Ansteigen der OH-Konzentration, die durch Absorptions- oder Emissionsverfahren gemessen wird. Die Gaszust?nde sind in einem Temperaturbereich 1000 K≦T≦1560 K bei Drücken zwischen 0,6 und 1,3 bar variiert worden. Die Me?werte lassen sich durch eine Korrelationsgleichung darstellen mit τ in μs und Konzentrationen in mol cm⁻³. Mit Hilfe eines reaktionskinetischen Modells bestehend aus 29 Elementarreaktionen werden Computersimulationen des Zündverhaltens der verschiedenen Gemische durchgeführt. Die übereinstimmung zwischen berechneten und gemessenen OH-Induktionszeiten erscheint zufriedenstellend, wenn man bedenkt, da? keine kinetische Anpassung vorgenommen worden ist.     

Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes

The serum of some patients with insulin-resistant "diabetes" contains antibodies that bind to and block the cell membrane receptors for insulin. In this report, we have characterized the effects of the antireceptor antibodies on the interaction of (125)I-insulin with its receptor on the human lymphoblastoid cell line IM-9. Up to 95% of specific insulin binding can be inhibited by pretreatment of the cells with these immunoglobulins. The onset of the inhibitory effect is time- and temperature-dependent, and the effect is reversed extremely slowly if the cells are suspended in a large excess of antibody-free buffer. These features of antibody binding can be easily distinguished from those for insulin binding to its receptor. The inhibitory effect of the antibodies can be reversed by exposure of the cells to conditions known to elute surface immunoglobulins. The three antireceptor sera studied appear to alter the insulin-receptor interaction in different ways. Two antisera markedly reduce receptor affinity through combined effects on the insulin association and dissociation rates, and, additionally, have smaller effects on available receptor number. A third antiserum primarily affects available receptor number and has little effect on receptor affinity. All three antisera inhibit the capacity of insulin to promote negatively cooperative site-site interactions among insulin receptors. The data suggest that these autoantibodies to the insulin receptor bind to different determinants on the receptor and may therefore be useful as unique probes of insulin receptor structure and function.