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排序方式: 共有750条查询结果,搜索用时 843 毫秒
741.
742.
Felix Tobola Dr. Martin Lepšík Dr. Syeda Rehana Zia Dr. Hakon Leffler Dr. Ulf J. Nilsson Dr. Ola Blixt Dr. Anne Imberty Dr. Birgit Wiltschi 《Chembiochem : a European journal of chemical biology》2022,23(5):e202100593
Galectin-1 is a β-galactoside-binding lectin with manifold biological functions. A single tryptophan residue (W68) in its carbohydrate binding site plays a major role in ligand binding and is highly conserved among galectins. To fine tune galectin-1 specificity, we introduced several non-canonical tryptophan analogues at this position of human galectin-1 and analyzed the resulting variants using glycan microarrays. Two variants containing 7-azatryptophan and 7-fluorotryptophan showed a reduced affinity for 3’-sulfated oligosaccharides. Their interaction with different ligands was further analyzed by fluorescence polarization competition assay. Using molecular modeling we provide structural clues that the change in affinities comes from modulated interactions and solvation patterns. Thus, we show that the introduction of subtle atomic mutations in the ligand binding site of galectin-1 is an attractive approach for fine-tuning its interactions with different ligands. 相似文献
743.
Benedetta Girardi Martina Manna Sjors Van Klaveren Prof. Tihomir Tomašič Prof. Žiga Jakopin Prof. Hakon Leffler Prof. Ulf J. Nilsson Prof. Daniel Ricklin Prof. Janez Mravljak Dr. Oliver Schwardt Prof. Marko Anderluh 《ChemMedChem》2022,17(3):e202100514
Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 ligand, 3-O-[1-carboxyethyl]-β-d -galactopyranoside, by introducing modifications at positions 1 and 3 of the galactose. Affinity data measured by fluorescence polarization show that the most potent compound reached a KD of 12 μM. Furthermore, reasonable selectivity versus other galectins was achieved, making the highlighted compound a promising lead for the development of new selective and potent ligands for galectin-8 as molecular probes to examine the protein's role in cell-based and in vivo studies. 相似文献
744.
Paul Herrmann Sebastian Klimmer Thomas Lettau Mohammad Monfared Isabelle Staude Ioannis Paradisanos Ulf Peschel Giancarlo Soavi 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(37):2301126
With conventional electronics reaching performance and size boundaries, all-optical processes have emerged as ideal building blocks for high speed and low power consumption devices. A promising approach in this direction is provided by valleytronics in atomically thin semiconductors, where light-matter interaction allows to write, store, and read binary information into the two energetically degenerate but non-equivalent valleys. Here, nonlinear valleytronics in monolayer WSe2 is investigated and show that an individual ultrashort pulse with a photon energy tuned to half of the optical band-gap can be used to simultaneously excite (by coherent optical Stark shift) and detect (by a rotation in the polarization of the emitted second harmonic) the valley population. 相似文献
745.
Camilla Eriksson Prof. Sunithi Gunasekera Dr. Taj Muhammad Mingshu Zhang Ida Laurén Prof. Sara M Mangsbo Dr. Martin Lord Prof. Ulf Göransson 《Chembiochem : a European journal of chemical biology》2023,24(15):e202300103
The SARS-CoV-2 virus that causes COVID-19 is a global health issue. The spread of the virus has resulted in seven million deaths to date. The emergence of new viral strains highlights the importance of continuous surveillance of the SARS-CoV-2 virus by using timely and accurate diagnostic tools. Here, we used a stable cyclic peptide scaffolds to present antigenic sequences derived from the spike protein that are reactive to SARS-CoV-2 antibodies. Using peptide sequences from different domains of SARS-CoV-2 spike proteins, we grafted epitopes on the peptide scaffold sunflower trypsin inhibitor 1 (SFTI-1). These scaffold peptides were then used to develop an ELISA to detect SARS-CoV-2 antibodies in serum. We show that displaying epitopes on the scaffold improves reactivity overall. One of the scaffold peptides (S2_1146-1161_c) has reactivity equal to that of commercial assays, and shows diagnostic potential. 相似文献
746.
Screening of pulp can be expressed as a process where solid contaminants are removed from a pulp slurry without an excessive loss of fibres of acceptable quality. The impurities originate from the feedstock, or they are generated during the transport, handling, storage, or pulping process. The most typical impurities include bark, fibre bundles or shives, knots, plastic, rubber, and sand. Moreover, there are also other objectives for screening, such as the improvement of the pulp quality, savings in bleaching chemical consumption, and protection of process equipment. In industrial applications, pulp screening is typically carried out with more than one screen for a more beneficial screening result. The pulp screening equipment can be divided into different types by the separation technique employed, such as atmospheric or pressurized screens, centrifugal screens, vibrating screens, etc. In addition, there are other types of related equipment that are common in the pulp screening process, such as knotters, refiners, and hydrocyclones. The main objective of this review is to discuss the advantages and disadvantages of modern screening equipment as well as introduce contemporary screening strategies for chemical pulp mills. 相似文献
747.
748.
Dr.-Ing. Frank Holzer Dr. rer. nat. Markus Kraus Dr. rer. nat. habil. Ulf Roland 《化学,工程师,技术》2023,95(11):1834-1843
Fine drying plays a key role for the use and especially the feeding of hydrogen into the natural gas infrastructure. For thermal regeneration of the desiccant, radio waves can be used for direct dielectric heating of the packed bed. Depending on the zeolite used, NaX or NaY, both homogeneous heating and selective heating of the water-laden desiccant beds are possible. Drying reactors were designed and successfully tested based on the technology, so that an operational pressure-resistant prototype is now available for hydrogen drying. 相似文献
749.
Ulf Betke Danielle Chazaro Mendoza Michael Scheffler 《International Journal of Applied Ceramic Technology》2023,20(1):204-212
Open-celled aluminum nitride ceramic foams were prepared by the polymer sponge replication technique involving aqueous dispersions of passivated AlN. The amount of the Y2O3 and Dy2O3 as sintering aid was varied, and the effects on the densification, microstructure formation, phase composition, and finally, the thermal conductivity were investigated. A typical thermal conductivity of 1.1 W m−1 K−1 was determined for foams at a porosity level of 94.3 vol.%, on average. This measured foam thermal conductivity was subsequently modeled using different porosity ↔ thermal conductivity relations considering the different hierarchical levels of porosity in these foams. From these models, the thermal conductivity of the bulk AlN strut material was determined, correlated with the strut microstructure and the phase composition, and compared to literature data. 相似文献
750.
Ilze Lāce Sophia Bazzi Jon Uranga Anastasiya Schirmacher Prof. Dr. Ulf Diederichsen Prof. Dr. Ricardo A. Mata Prof. Dr. Nadja A. Simeth 《Chembiochem : a European journal of chemical biology》2023,24(16):e202300270
Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus their propensity to engage in PPIs can be influenced by the introduction of peptide staples on the side chains. In particular, light-controlled staples based on azobenzene photoswitches and their structural influence on helical peptides have been studied extensively. In contrast, photolabile staples bearing photocages as a structural key motif, have mainly been used to block supramolecular interactions. Their influence on the secondary structure of the target peptide is under-investigated. Thus, in this study we use a combination of spectroscopic techniques and in silico simulations to systematically study a series of helical peptides with varying length of the photo-labile staple to obtain a detailed insight into the structure-property relationship in such photoresponsive biomolecules. 相似文献