Osteoporosis in rheumatoid arthritis

Patients with rheumatoid arthritis (RA) develop both periarticular and generalized osteoporosis. Periarticular osteopenia in appendicular bones occurs early in the course of RA and is one of the earliest radiological signs of RA. An uncoupled state in bone resorption-formation linkage, contributes to the development of periarticular osteopenia and it might be mediated through an increased productions of cytokines and prostaglandins by synovium and bone marrow. Accordingly, early suppression of rheumatoid synovitis is necessary for the prevention of periarticular osteopenia. Generalized osteoporosis is also common in RA and leads to increased risk of fractures. Generalized osteoporosis considered to be multifactorial and factors contributing to lumbar osteoporosis might be different from those to loss of appendicular bones, such as femur and radius. Corticosteroids and menopausal state are important risk factors for lumbar osteoporosis. Rheumatoid activity and reduced physical activity are also important determinants. According to the previous studies, however, the influence of functional impairment is more prominent in the femoral BMD compared to spinal BMD. In addition to control of RA and maintenance of physical activity, hormone replacement therapy (HRT) and bisphosphonate are possible agents for the treatment of osteoporosis in RA patients, especially postmenopausal women.     

Xerographic development using single-component nonmagnetic toner

No magnetic material is necessary for this system. A thin layer of nonmagnetic toner is formed on the surface of a metal roller by means of an elastic plate which is pressed against the roller. The toner particles are charged triboelectrically by friction with the metal plate. The toner layer is attached to the roller by electrostatic force, and is carried around to the photosensitive drum. The latent image is developed with the noncontact development technique. The insulative toner developed for this system has a superior triboelectric characteristic. A model for toner charging is shown. The numerical calculations based on the model agree well with the experimental results. The model suggests that the metal plate controls the toner charge     

Degradation mechanisms of GaAs PHEMTs in high humidity conditions

We have studied the degradation mechanisms of AlGaAs/InGaAs pseudomorphic HEMTs (PHEMTs) under high humidity conditions (85 °C, 85% relative humidity). The degraded samples under high humidity conditions show a decrease in maximum drain current (I_max) and a positive shift in threshold voltage (V_th). Cross-sectional transmission electron microscopy (TEM) images from the deteriorated devices reveal an existence of damaged recess surface region and a peeling of a passivation film (SiN_x). The secondary ion mass spectrometry (SIMS) depth profile at the interface between the passivation film and AlGaAs surface also indicates the diffusion of gallium (Ga), arsenic (As) and aluminum (Al) into the passivation film. The degradation of PHEMTs arises from mainly two mechanisms: (1) the positive shift in V_th due to stress change under the gate caused by the peeling of passivation films, and (2) the decrease in I_max due to the net carrier concentration reduction of the AlGaAs carrier supply layer caused by the combination of surface degradation at the AlGaAs recess regions and diffusion of Ga, As and Al at the interface between the passivation film and AlGaAs surface. A special treatment just prior to the deposition of SiN_x films on the devices effectively suppresses the degradation of PHEMTs under high humidity conditions without degradation of the high frequency performance.     

Adenocarcinoma arising in a tailgut cyst: report of a case

We report herein the unusual case of a 66-year-old woman found to have adenocarcinoma arising in a tailgut cyst. The patient had been observed for 6 months following the discovery of a presacral cystic mass measuring 10 x 9 cm for which she had refused surgery. The serum tumor marker, carcinoembryonic antigen, became slightly elevated, and diagnostic imaging distinctly revealed a tumorous lesion with papillary projection into the cyst lumen. The cystic mass was then excised through the transsacral approach. The pathological findings were compatible with moderately differentiated adenocarcinoma arising in a tailgut cyst. This entity is extremely rare, and only six cases, including our own, have been reported in the English literature. Early complete excision is advised because it is almost impossible to determine for certain whether presacral cystic masses are benign or malignant prior to surgery.     

High-speed long-wavelength optical modulation in InGaAs/InAlAs multiple quantum wells

A long-wavelength optical modulator has been fabricated which makes use of an electroabsorption effect in multiple quantum wells (MQWs). Here, InGaAs/InAlAs MQWs are prepared in a PIN configuration using molecular beam epitaxy (MBE). The rise time of the detected pulse modulation signal has been measured at 190 ps. This response level has been attributed to the detecting system response and RC time constant, and not to such intrinsic effects as carrier lifetime.     

Reduced sialylation of glycoproteins in nasal glands of patients with chronic sinusitis

This study was conducted to investigate the sialylations of glycoproteins in the nasal glands of patients with chronic sinusitis. Sialic acids were detected using lectin histochemistry, and the mRNA of sialyltransferase was evaluated by in situ hybridization histochemistry. Sambucus nigra agglutinin (SNA), which recognizes terminal sialic acids, strongly stained the glandular mucous cells of normal subjects, but not those of patients with chronic sinusitis. In situ hybridization histochemistry showed that the expression of alpha2,6 sialyltransferase mRNA was decreased in the secretory cells of patients with chronic sinusitis. Our present results suggest that a reduction in sialyltransferase activity at the mRNA level in the nasal glands may lead to the persistence of chronic sinusitis.     

Adjuvant therapies in combination with pancreatectomy for carcinoma of the pancreas

In the treatment of adenocarcinoma of the pancreas, surgical resection is the only curative strategy. However, the long-term survival rate after pancreatectomy remains poor, and most patients died of loco-regional and/or hepatic recurrence. Thus, we should perform effective adjuvant therapies in combination with surgery, in order to completely prevent these two types of cancer relapse. The present article is designed to introduce the recent reports on the adjuvant chemo-and/or radio-therapies for this cancer. As for loco-regional control, extended pancreatectomy plus chemoradiation seems to be most promising, and preoperative chemoradiation will be more popular in the near future. In order to decrease hepatic metastasis, our "2-channel chemotherapy", a continuous infusion of 5-FU via both hepatic artery and portal vein, is very promising. If postoperative survival is improved by combining these two types of regional therapy, the role of pancreatectomy will be enlarged and more widely understood in the near future.     

X-ray computed tomography used to measure fiber orientation in CFRP laminates

This paper explains a new method to measure the fiber orientation in carbon fiber reinforced plastics (CFRP) laminates from X-ray CT images. In the method, the fiber orientation is analyzed by the application of digital image correlation (DIC) method to the acquired tomographic images. Using DIC, the brightness pattern, which results from the radiodensity difference between fiber and resin, is compared between two different planes in the thickness direction. Then, the three-dimensional displacement of the brightness pattern, which indicates the fiber orientation, can be measured. This study applied the proposed method to a quasi-isotropic CFRP laminate. After X-ray CT imaging, the sample was sectioned and polished. The fiber orientation was then measured experimentally using microscopy. The fiber orientation calculated using the proposed method agrees very well with the experimentally measured one. After demonstrating the validity of the proposed method, we applied it to a plain woven CFRP laminate. Results revealed that an invalid fiber orientation might be calculated for fibers parallel to the plane of the CT image, or for the fiber orientation of the pattern around the outer edge of CT images.     

The morphology of α-Fe crystals which grow in the amorphous Fe80(C1−xBx)20 alloys

Crystallization behaviour of amorphous Fe₈₀(C_1–x B _x )₂₀ alloys, obtained by splat-cooling technique, for x values ranging from zero to unity has been investigated mainly by transmission electron microscopy. The crystalline phase which first appeared in the amorphous matrix was -Fe for all alloys studied. However, the morphology of -Fe phase changed from a spherical shape for low x values to a watch-glass shape for intermediate x values and to dendritic for large x values. The nucleation of -Fe crystals was homogeneous for low x samples while preferred nucleation on edges and surfaces was noted for samples with higher x values. The final volume fraction of -Fe phase before the appearance of the second crystalline phase increased with the increase in x.