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991.
Jong-Jin Choi Jungho Ryu Byung-Dong Hahn Woon-Ha Yoon Dong-Soo Park 《International Journal of Applied Ceramic Technology》2009,6(6):687-691
A conducting 8-μm-thick LaNiO3 (LNO) film was deposited on a Ti substrate by aerosol deposition for use as a diffusion barrier between a lead zirconate titanate (PZT) and a Ti substrate during postannealing. The deposited 20-μm-thick PZT films were annealed at 800°C. The PZT film deposited without LNO was cracked and partially detached from the substrate after postannealing, presumably due to a severe reaction with the Ti substrate, while no significant reactions were observed when the LNO buffer layer was used. The remnant polarization and relative dielectric constant of the 20-μm-thick annealed PZT films deposited on the LNO-buffered Ti substrate were 43 μC/cm2 and 1010, respectively. 相似文献
992.
Mamoru Ishida Takeo Uehara Toshio Arai Hideki Takeda Tadashi Yamaguchi Takeshi Taniguchi Tetsuya Katsumi Masayuki Kobayashi Hitoshi Ofune 《Intermetallics》2002,10(11-12)
The performance of MU/SC conversion sleeve produced by bulk metallic glass (Zr55Al10Ni5Cu30) was examined. A precision die-casting method was applied to improve size accuracy. The size accuracy of the conversion sleeve produced by the precision die-casting method was ±1 μm, and optical insertion loss (Li) was less than 0.3 dB for a standard value. The wear resistance of metallic glass is improved by surface oxidation treatment in air at 673 K. The MU/SC conversion sleeve produced from bulk metallic glass has superior characteristics for optical parts. 相似文献
993.
Hwani Ryu Ky-Youb Nam Hyo Jeong Kim Jie-Young Song Sang-Gu Hwang Jae Sung Kim Joon Kim Jiyeon Ahn 《International journal of molecular sciences》2021,22(14)
More than 80% of colorectal cancer patients have adenomatous polyposis coli (APC) mutations, which induce abnormal WNT/β-catenin activation. Tankyrase (TNKS) mediates the release of active β-catenin, which occurs regardless of the ligand that translocates into the nucleus by AXIN degradation via the ubiquitin-proteasome pathway. Therefore, TNKS inhibition has emerged as an attractive strategy for cancer therapy. In this study, we identified pyridine derivatives by evaluating in vitro TNKS enzyme activity and investigated N-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-1-(2-cyanophenyl)piperidine-4-carboxamide (TI-12403) as a novel TNKS inhibitor. TI-12403 stabilized AXIN2, reduced active β-catenin, and downregulated β-catenin target genes in COLO320DM and DLD-1 cells. The antitumor activities of TI-12403 were confirmed by the viability of the colorectal cancer cells and its lack of visible toxicity in DLD-1 xenograft mouse model. In addition, combined 5-FU and TI-12403 treatment synergistically inhibited proliferation to a greater extent than that in a single drug treatment. Our observations suggest that TI-12403, a novel selective TNKS1 inhibitor, may be a suitable compound for anticancer drug development. 相似文献
994.
Václav Jurčík Kenzo Arai Matthew M. Salter Yasuhiro Yamashita Shū Kobayashi 《Advanced Synthesis \u0026amp; Catalysis》2008,350(5):647-651
Niobium‐based chiral Lewis acid was found to be highly effective catalyst for aza‐Diels–Alder reactions of imines with Danishefsky‘s dienes. The reactions proceed in high yield with high enantioselectivity for both aromatic and aliphatic imines. The developed methodology was applied to total synthesis of (+)‐anabasine. 相似文献
995.
In Japan, to satisfy the steadily increasing demand for electricity in urban areas, 1100 kV substation equipment have been developed, and a part of the 1100 kV transmission lines were constructed. 1100 kV substations would be located in the mountainous areas, so they must be made as compact as possible to meet installation space constraints and to harmonize with the natural environment. Thus, 1100 kV substations adopt Gas Insulated Switchgear (GIS) as the main circuit from transmission line entrance to transformer bushings. Because the substation is one of the most important items in a 1100 kV system, the equipment in 1100 kV substations requires to be of extremely high reliability. Additionally, various technologies that have not been used in 500 kV and lower systems are applied. To establish carefully the 1100 kV equipment technologies, TEPCO constructed a UHV Equipment Test Station (in the 500 kV Shin-Haruna substation), which has the minimum component of a 1100 kV substation-3 single-phase transformers (3000 MVA bank) and 1 bay of GIS (8000 A). Connecting these facilities to the actual grid in 1996, a field verification test has been carried out. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. 相似文献
996.
Shusuke Kanazawa Musubu Ichikawa Youki Fujita Ryu Koike Toshiki Koyama Yoshio Taniguchi 《Organic Electronics》2008,9(4):425-431
The relationship between thiophene sequences and organic thin-film transistor (OTFT) characteristics was studied to determine their effect on ionization potential, molecular orientation, and air stability. Two types of molecular structures were used: continuous sequence and divided sequence thiophenes. The length of thiophene sequence did not affect FET characteristics but did affect ionic potential and air stability. Furthermore, materials with divided thiophene sequences showed no change in OTFT characteristics when exposed to air. These results suggest that separation of thiophene sequences can improve air stability, which is a problem of thiophene-based materials. 相似文献
997.
Yamada E. Sano A. Masuda H. Yamazaki E. Kobayashi T. Yoshida E. Yonenaga K. Miyamoto Y. Ishihara K. Takatori Y. Yamada T. Yamazaki H. 《Electronics letters》2008,44(24):1417-1418
Spectrally efficient (2bit/s/Hz) 1 Tbit/s DWDM transmission of 111 Gbit/s no-guard-interval PDM CO-OFDM signals with 50 GHz spacing over DSF is demonstrated. The record transmission distance of 2100 km was achieved for a 100 Gbit/s-data-rate CO-OFDM system. 相似文献
998.
A new hybrid phosphine was designed. The phosphine combines two common structural characteristics found among the effective phosphine ligands reported recently, namely, three tert‐alkyl substituents binding to the phosphorus and an aryl group at an appropriate position. A hybrid phospine/palladium system is versatile and effective for the coupling reaction of various aryl halides with primary and secondary amines including carbazole. 相似文献
999.
Yoshikazu Kobayashi Hikari Hamada Yasuhiro Yamaguchi Hidekazu Ikezaki Kiyoshi Toko 《IEEJ Transactions on Electrical and Electronic Engineering》2009,4(6):710-719
This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. 相似文献
1000.
Using a starter culture containing Lactococcus lactis subsp. cremoris and Acetobacter orientalis, repeated-batch culture for fermented-milk production was carried out for 14 d. The pH decreased to approximately 4.3 and the milk solidified stably when the mixing ratio of fermented-milk to fresh milk was set at a level as high as 10%. The microbial population gradually changed as the culture progressed, and the cell densities of lactic and acetic acid bacteria finally leveled off to constant values. The quality of the fermented-milk became almost constant with respect to the changes in the cell densities of the lactic and acetic acid bacteria. Escherichia coli was then inoculated into the fermented-milk to simulate household contamination. E. coli was washed out with the progress of the repeated-batch culture, and thus showed no adverse effects on the fermented-milk production. 相似文献