Grid computing: a STOPE view

Grid computing is emerging as the foundation upon which virtual organizations can be built. Such organizations are becoming of increasing importance for tackling various projects, both in academic and in business fields. This paper is concerned with presenting an integrated view of the grid to readers interested in understanding it, or perhaps in developing it further or making use of it in the future. The target view is based on the STOPE (strategy/technology/organization/people/environment) framework that has previously been used to integrate the issues of various information technology problems over its well‐defined domains. For strategy, the view considers the reasons associated with the need for the grid, including grid services and grid benefits. For technology, the technical components of the grid and their functions are taken into account. For organization, the organizations concerned with the development, technology production, service provisioning and use of the grid are considered. For people, those associated with the grid in the related organizations are taken into account. For the environment, rules, practices and support associated with the grid are discussed. Finally, the paper emphasizes questions that need to be answered in order to contribute to the future development of the grid. Copyright © 2006 John Wiley & Sons, Ltd.     

Effect of captopril, losartan, and bradykinin on early steps of insulin action

Insulin initiates its metabolic and growth-promoting effects by binding to the alpha subunit of its receptor, thereby activating the kinase in the beta subunit. This event leads to tyrosyl phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1), which in turn associates with and activates phosphatidylinositol (PI) 3-kinase. The clinical use of ACE inhibitors has been associated with increased insulin sensitivity. However, the exact molecular mechanism is unknown. In the present study, we examined the phosphorylation status of the insulin receptor and IRS-1, as well as the association between IRS-1 and PI 3-kinase in the liver and muscle of 20-month-old rats treated acutely with captopril, using immunoprecipitation with antipeptide antibodies to the insulin receptor and IRS-1, and immunoblotting with antiphosphotyrosine and anti-PI 3-kinase antibodies. Insulin stimulation increased receptor autophosphorylation to 462 +/- 253% (P < 0.05) in the liver and 697 +/- 78% (P < 0.001) in the muscle of ACE inhibitor-treated rats. There were also increases to 250 +/- 17% (P < 0.001) and 280 +/- 50% (P < 0.05) in the insulin-stimulated IRS-1 phosphorylation levels in the liver and muscle, respectively, of animals treated with captopril. The insulin-stimulated IRS-1 association with PI 3-kinase rose to 305 +/- 20% (P < 0.001) in liver and 267 +/- 48% (P < 0.05) in muscle. Losartan, an ANG receptor blocker, had no significant effect on insulin-stimulated IRS-1 phosphorylation in both tissues. The acute administration of bradykinin increased insulin-stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 in the liver and muscle. These data demonstrate that ACE inhibitors modulate the early steps of insulin signaling, and that this effect may be simulated by the administration of bradykinin.     

Fill factor losses in ZnO/CdS/CuGaSe2 single-crystal solar cells

Current–voltage characteristics of ZnO/CdS/CuGaSe₂ single-crystal solar cells with solar conversion efficiency values of η=3.5%, 6.0%, 6.7% and 9.7% were analyzed using the single diode equation. The effect of each of the achieved parameters on the fill factor was calculated. The calculations revealed that the fill factor reduction due to the series resistance remained below Δff=4.4% under illumination, while this effect would have been much higher if the illumination had not reduced the series resistance markedly. The calculation furthermore revealed that the fill factor reduction due to the shunt resistance remained below Δff=3.6% under illumination. This effect would have been negligible if the illumination had not also reduced the shunt resistance in all studied cells. The increase of the saturation current density under illumination has brought about considerably high fill factor losses (at least Δff=8.3%) in all studied cells. Already the dark saturation current density and the diode ideality factor in such cells have been found to be much higher than the ones in the cells based on CuInSe₂. This seems to be the most substantial restriction to the fill factor, and thus to the performance, of solar cells based on CuGaSe₂. An explanation for this different behavior seems to lie in the different band structures of these cells.     

Effect of antistripping additives on environmental damage of bituminous mixtures

The main objective of this study was to investigate the effect of environmental damage (stripping) on the hot mix asphalt (HMA) creep behavior. To achieve this objective, 24 different HMA combinations using different mix parameters were evaluated for their resistance to static creep deformations. The mix parameters include: two types of asphalt cement, three types of aggregate gradation, and two types of antistripping additives (limestone dust and calcium stearate hydroxide). Marshall specimens were prepared at optimum asphalt contents and tested for static creep. Part of the prepared specimens were exposed to freezing–thawing conditioning according to AASHTO T283.     

Parts verification for multi-level-dependent demand manufacturing systems: a recognition and classification structure

This research has developed and implemented a part recognition and classification structure to execute parts verification in a multi-level-dependent demand manufacturing system. The part-recognition algorithm enables the parent and child relationship between parts to be recognised in a finite-capacitated manufacturing system. This algorithm was developed using the SIMAN simulation language and implemented in a multi-level-dependent demand manufacturing simulation model. The part-classification structure enables the modelling of a multi-level-dependent demand manufacturing system between parts to be carried out effectively. The part-classification structure was programmed using Visual Basic Application (VBA) and was integrated into the work-to-list generated from a simulated materials requirements planning (MRP) model. This part-classification structure was then implemented in the multi-level-dependent demand manufacturing simulation model. Two stages of implementation, namely, parameterisation and execution, of the part recognition and classification structure were carried out. A real case study was used and five detailed steps of execution were processed. Simulation experiments and MRP were run to verify and validate the part recognition and classification structure. The results led to the conclusion that implementation of the recognition and classification structure has effectively verified the correct parts and sub-assemblies used for the correct product and order. No parts nor sub-assembly shortages were found, and the quantity required was produced. The scheduled release for some orders was delayed due to overload of the required resources. When the loading is normal, all scheduled release timing is adhered to. The recognition and classification structure has a robust design; hence, it can be easily adapted to new system parameters to study different or more complex cases.     

The effects of accumulated timing jitter on some sine wavemeasurements

This paper investigates the effects of accumulated timing jitter on the signal-to-noise ratio (SNR) and on the phase angle measurement of real sine waves. These measurements are done via the Fast Fourier Transform (FFT) method. Accumulated timing jitter occurs when the sine wave is sampled by an unstable clock where the clock periods are randomly changing. Also, accumulated jitter is a problem in ramp-type bases that were often used in sampling oscilloscopes. Expressions for an estimate of the signal-to-noise ratio [SNR_(est.)] and phase variance in terms of the jitter distribution parameters and the number of FFT points (N) are derived. The derived expressions are verified through computer simulations. Finally, a comparison between independent and accumulated jitter is presented     

Fatal air embolism: a complication of manipulation of a cavitating metastatic lesion of the liver

The use of NMR spectroscopy in combinatorial chemistry has provided a versatile tool for monitoring combinatorial chemistry reactions and for assessing ligand-receptor interactions. The application of magic angle spinning NMR is widespread and has allowed structure determination to be performed on compounds attached to solid supports. A variety of two-dimensional NMR techniques have been applied to enhance the usability of the magic angle spinning NMR data. New developments for solution NMR analysis include high performance liquid chromatography, NMR, mass spectroscopy and flow NMR. NMR based methods currently being investigated may prove valuable as compound screening tools.     

Toward the development of a standard e‐readiness assessment policy

Information networking for digital integration is becoming of increasing importance for national and international organizations concerned with development. E‐Readiness assessments, for various countries, are associated with the investigation of their state of readiness for such integration. They help in understanding the problems that need to be resolved in order to avoid digital divide, or even digital isolation, from world development. Such assessments lack standard policies, which provide unified measures that ease evaluations, support analysis and comparisons, and help in diagnosing problems and deriving solutions. This paper is concerned with the development of a standard e‐readiness assessment policy. It provides a base for the development of such a policy, and hopes that this base will contribute to a future standard international policy. Copyright © 2003 John Wiley & Sons, Ltd.