全文获取类型
收费全文 | 1179篇 |
免费 | 82篇 |
专业分类
电工技术 | 9篇 |
综合类 | 25篇 |
化学工业 | 398篇 |
金属工艺 | 15篇 |
机械仪表 | 15篇 |
建筑科学 | 57篇 |
矿业工程 | 3篇 |
能源动力 | 19篇 |
轻工业 | 214篇 |
水利工程 | 13篇 |
无线电 | 61篇 |
一般工业技术 | 166篇 |
冶金工业 | 79篇 |
原子能技术 | 4篇 |
自动化技术 | 183篇 |
出版年
2024年 | 3篇 |
2023年 | 13篇 |
2022年 | 47篇 |
2021年 | 44篇 |
2020年 | 33篇 |
2019年 | 39篇 |
2018年 | 31篇 |
2017年 | 37篇 |
2016年 | 41篇 |
2015年 | 48篇 |
2014年 | 46篇 |
2013年 | 71篇 |
2012年 | 65篇 |
2011年 | 78篇 |
2010年 | 90篇 |
2009年 | 50篇 |
2008年 | 88篇 |
2007年 | 60篇 |
2006年 | 46篇 |
2005年 | 32篇 |
2004年 | 35篇 |
2003年 | 32篇 |
2002年 | 27篇 |
2001年 | 17篇 |
2000年 | 16篇 |
1999年 | 21篇 |
1998年 | 18篇 |
1997年 | 19篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 16篇 |
1993年 | 12篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有1261条查询结果,搜索用时 15 毫秒
21.
As web technology and (big) data continue to transform how we organize ourselves, scholarly research increasingly zooms in on the socio-material conditions of citizen participation and public engagement, the objects and devices that organize publics. Where social issues may often be the driver of such public engagement, increasingly the city and, more specifically, the neighborhood itself have become a central objects connecting their inhabitants through online networks and neighborhood events. Tools and apps for citizen participation then weave together neighborhood stakeholders (e.g. inhabitants, municipal parties and entrepreneurs). This paper zooms in on a sample of 40 such tools that enable and organize bottom-up citizen participation in the city of Amsterdam. Combining a theoretical framework with content analysis, digital methods and data visualization, this paper marks the starting point of a longitudinal analysis of online tools for the urban bottom-up movement. 相似文献
22.
The articles collected in this number all originate from a section of the 2004 annual meeting of the Deutsche Gesellschaft für Geschichte der Medizin, Naturwissenschaft und Technik.The section was organized by the Berlin Feminist Science Studies Workgroup (BFSSW) at the Max Planck Institute for the History
of Science, Berlin. The contributions are dedicated to recent accounts and research topics in a field constituted by the intersection
between 20th century (life) sciences and gender studies.They view modern life sciences as situated in hybrid fields of theory
and practice, public and scientific discourse, of experimental procedures and practices of control. Methodological approaches
range from Derrida’s notion of deconstruction, Foucault’s regulatory power and governmentality, Butler’s method of analyzing
performativity and Haraway’s situated knowledge. They focus on dispositifs of research and regulation, visualizing procedures
in the human sciences, and the emergence of new objects of biopolitics. One contribution focuses on the ‘politics of emotions’
and the paradoxical effects of laughter in ‘sexed’ and ‘gendered’ discourses and explores the productivity of humor for a
gender-sensitive way of ‘doing history’. This introduction deals with recent developments in – mainly German – gender studies
during the last two decades under the triple perspective of women in science, science of gender and gender in science.
Geschlechterforschung ist Wissenschaftsforschung – Wissenschaftsforschung ist Geschlechterforschung Einführung in den Themenschwerpunkt “Wissenschaftsgeschichte als Geschlechtergeschichte”相似文献
23.
24.
Sabine Anderweit Christoph Licht Angela Kribs Christiane Woopen Klaus Bergdolt Prof. Dr. Bernhard Roth 《Ethik in der Medizin》2004,16(1):37-47
Definition of the problem: Physicians and nurses who work in neonatology—as in intensive care at all—are often forced to decide whether to stop or to continue with the treatment of a severely ill patient. The literature provides several decision making instruments, which are meant to help and to rationalize such decisions. Method and conclusion: Two of these instruments (“Schema zur ethischen Urteilsbildung nach dem Muster der aristotelischen Ethik”, Honnefelder 1994; “Nimwegener Methode für ethische Fallbesprechung”, Gordijn 1998) were tested by retrospectively examining two cases of our NICU. Results of our study show that the use of a decision making instrument is basically helpful. But the above mentioned instruments showed also shortcomings when used in the framework of neonatology. Therefore we developed the “Kölner Arbeitsbogen zur ethischen Entscheidungsfindung in der Neonatologie”, which is adapted to the specific needs of neonatology. 相似文献
25.
Mojza Eva J.; Lorenz Christian; Sonnentag Sabine; Binnewies Carmen 《Canadian Metallurgical Quarterly》2010,15(1):60
This study focused on the role of volunteer work for daily recovery from work. In a 1-week diary study with 166 employees, we assessed the amount of time spent on volunteer work during leisure time, and the recovery facets of psychological detachment from work (i.e., mentally switching off from work), mastery experiences (i.e., pursuing challenging activities), and community experiences (i.e., cultivating relationships) every day before participants went to bed. Results from hierarchical linear modeling (n = 529 days) showed volunteer work during leisure time to be positively related to mastery experiences and community experiences suggesting volunteer work to contribute to successful recovery by creating new resources. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
26.
27.
Kay-Arne Walther Jos Roberto Gonzales Sabine Grger Benjamin Ehmke Dogan Kaner Katrin Lorenz Peter Eickholz Thomas Kocher Ti-Sun Kim Ulrich Schlagenhauf Raphael Koch Jrg Meyle 《International journal of molecular sciences》2022,23(13)
Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov =ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression. NCT00707369相似文献
28.
Constant folding is a well-known optimization of compilers which evaluates constant expressions already at compile time. Constant folding is valid only if the results computed by the compiler are exactly the same as the results which would be computed at run-time by the target machine arithmetic. We classify different arithmetics by deriving a general condition under which a target-machine arithmetic can be replaced by a compiler arithmetic. Furthermore, we consider integer arithmetics as a special case. They can be described by residue class arithmetics. We show that these arithmetics form a lattice. Using the order relation in this lattice, we establish a necessary and sufficient criterion under which constant folding can be done in a residue class arithmetic that is different from the one of the target machine. Concerning formal verification, we have formalized our proofs in the Isabelle/HOL system. As examples, we discuss the Java and C integer arithmetics and show which compiler arithmetics are valid for constant folding. This discussion reveals also potential sources of incorrect behavior of C compilers. 相似文献
29.
Annika Kempmann Thomas Gensch Andreas Offenhusser Irina Tihaa Vanessa Maybeck Sabine Balfanz Arnd Baumann 《International journal of molecular sciences》2022,23(12)
Calcium (Ca2+) ions play a pivotal role in physiology and cellular signaling. The intracellular Ca2+ concentration ([Ca2+]i) is about three orders of magnitude lower than the extracellular concentration, resulting in a steep transmembrane concentration gradient. Thus, the spatial and the temporal dynamics of [Ca2+]i are ideally suited to modulate Ca2+-mediated cellular responses to external signals. A variety of highly sophisticated methods have been developed to gain insight into cellular Ca2+ dynamics. In addition to electrophysiological measurements and the application of synthetic dyes that change their fluorescent properties upon interaction with Ca2+, the introduction and the ongoing development of genetically encoded Ca2+ indicators (GECI) opened a new era to study Ca2+-driven processes in living cells and organisms. Here, we have focused on one well-established GECI, i.e., GCaMP3.0. We have systematically modified the protein with sequence motifs, allowing localization of the sensor in the nucleus, in the mitochondrial matrix, at the mitochondrial outer membrane, and at the plasma membrane. The individual variants and a cytosolic version of GCaMP3.0 were overexpressed and purified from E. coli cells to study their biophysical properties in solution. All versions were examined to monitor Ca2+ signaling in stably transfected cell lines and in primary cortical neurons transduced with recombinant Adeno-associated viruses (rAAV). In this comparative study, we provide evidence for a robust approach to reliably trace Ca2+ signals at the (sub)-cellular level with pronounced temporal resolution. 相似文献
30.
Marleen Julia Meyer Simon Falk Sarah Rmer Clarissa Prinzinger Sabine Tacke Joachim Geyer Stefan Simm Mladen Vassilev Tzvetkov 《International journal of molecular sciences》2022,23(9)
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs. 相似文献