Numerical and analytical study of severity of cracks in cylindrical and spherical shells

The present study deals with the severity of cracks in pressure equipments, where such defects are often involved. Our work is particularly concerned with the problem of cylindrical shells and also the little well-known problem of spherical shells, including all sorts of practical defects, namely axisymmetric or semi-elliptic, both internal and external cracks. The stress intensity factor in the linear elastic domain and the J integral in the elastoplastic range are performed using the finite element method and compared to the results provided by the application of the semi-analytical A16 or R6 simplified criteria, depending on a limit load calculation. The nocivity of the defects depends on the crack shape and size and other structural geometrical parameters. Use is made of a polynomial decomposition of the stress field in the vicinity of the crack in order to cover all industrial loadings. All the numerical results, for a wide range of shell and crack geometries, are depicted using appropriate tables and curves in order to check the fracture criteria more easily.     

Explicit and implicit animation with fuzzy constraints of a versatile multi‐body system for virtual hand surgery

This work is designed to control the movement of hand structural agents under external action, using the implicit animation driven by explicit animation technique (AI‐CAE technique). Starting from the configuration of a hand at rest obtained by a 3D scanner and after meshing of the structural agents, we seek the configuration of the rigid agents under orthopaedic surgeon external action and interacting reliance of deformable and rigid agents. We have developed a model and software tools to answer this interactive application with adaptive execution. The first contribution comes from notations and definition of a versatile multi‐body system dedicated to the explicit and implicit animation. The second contribution comes from the implicit animation driven by explicit animation itself, and from its ability to mimic the role of cartilages and ligaments. The resulting technique is applied to the bone structure consistency of a specific human hand in the context of virtual hand orthopaedic surgery. The versatile specific multi‐body is made up of hierarchical interacting agents conceivable as a construction set of rigid bones with cartilages–ligaments and underlying links. The explicit animation produces a desired configuration from geometric command parameters of torsion, flexion, pivot and axis shifting, given in a scenario subdivided into temporal sequences. The implicit animation controls the movement by implementing a physics‐based model and fuzzy constraints of position and orientation. It gives better configuration than the explicit animation because it takes into account the interactions between agents, and it gives a neat solution without the problems of complexity due to geometric modelling. A methodology based on the AI‐CAE technique is discussed, medical expertise and validation tests are presented. Copyright © 2011 John Wiley & Sons, Ltd.     

Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts

The ubiquitin-proteasome system regulates biological processes in normal and diseased states. Recent investigations have focused on ubiquitin-dependent modifications and their impacts on cellular function, commitment, and differentiation. Ubiquitination is reversed by deubiquitinases, including ubiquitin-specific peptidases (USPs), whose roles have been widely investigated. In this review, we explore recent findings highlighting the regulatory functions of USPs in osteoblasts and providing insight into the molecular mechanisms governing their actions during bone formation. We also give a brief overview of our work on USP53, a target of PTH in osteoblasts and a regulator of mesenchymal cell lineage fate decisions. Emerging evidence addresses questions pertaining to the complex layers of regulation exerted by USPs on osteoblast signaling. We provide a short overview of our and others’ understanding of how USPs modulate osteoblastogenesis. However, further studies using knockout mouse models are needed to fully understand the mechanisms underpinning USPs actions.     

Experimental and numerical study of stress–strain state of pressurised cylindrical shells with external defects

Work presents the experimental technique with using of strain gauges for determining of strain distribution near longitudinal external defects of semielliptical shape in pressurised cylindrical shells and an appropriate procedure of numerical calculation based on a finite element method (FEM) for assessment of strain state near such defects. Numerical assessment of elastic stress distribution at bottom of external semielliptical notch in pressurised cylindrical shell is in a good agreement with the data received on the base of different analytical models. Here, the FEM results and data based on Glinka-Newport model are the most close for maximal stress. A comparison an experimental and calculation results showed on their acceptable coincidence and this fact gives the ground for using the numerical calculations instead labour-intensive and expensive experimental tests.     

Primary ciliary dyskinesia: diagnosis and standards of care

Primary ciliary dyskinesia (PCD) is characterized by disease of the upper and lower respiratory tract, in association with visceral mirror image arrangement in 50% of cases, due to abnormal structure and/or function of cilia. The purpose of this paper is to review the clinical features, diagnosis and management of PCD. Presentations include neonatal respiratory distress, recurrent lower respiratory tract infection, chronic rhinosinusitis and male infertility. PCD enters the differential diagnosis of bronchiectasis, atypical asthma, and unusually severe upper airway disease. Diagnosis is by a cascade of investigations, starting with the saccharin test in patients older than 10 yrs; ciliary beat frequency and pattern on light microscopy; and electron microscopy to assess ciliary morphology and orientation. It is important not to confuse primary and secondary ciliary abnormalities. Nasal nitric oxide is low in PCD, and this measurement shows promise as a screening test for PCD. Diagnosis is important, in order to prevent the development of bronchiectasis and to avoid any unnecessary otorhinolaryngological procedures. Regular follow-up is essential, and management should be multidisciplinary, with input from centres with a special interest in PCD, having access to paediatric and adult chest physicians, otolaryngologists and audiological physicians, physiotherapists, counselling services and fertility clinics. The prognosis is good, but morbidity can be considerable if PCD is incorrectly managed.     

Application of the geometrically dependent gain coefficient model to describe amplified spontaneous emission behavior in organic solid laser materials: theoretical considerations

A model of geometrically dependent gain coefficient is applied to small-sized media to explain the amplified spontaneous emission intensity and bandwidth reduction along the light propagation direction. The model is used for two typical experimental examples of photo-pumped pyrromethene 567-doped polymer and BuEH-PPV conjugated polymer waveguides, and excellent consistency with the measurements is obtained. The calculations are performed both analytically and numerically, where the effect of saturation on the gain coefficient for the homogeneously broadened line-shape upon using a 4-level system is considered.