全文获取类型
收费全文 | 316篇 |
免费 | 34篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 4篇 |
综合类 | 1篇 |
化学工业 | 124篇 |
金属工艺 | 4篇 |
机械仪表 | 6篇 |
建筑科学 | 7篇 |
能源动力 | 10篇 |
轻工业 | 43篇 |
水利工程 | 6篇 |
石油天然气 | 5篇 |
武器工业 | 1篇 |
无线电 | 26篇 |
一般工业技术 | 75篇 |
冶金工业 | 3篇 |
原子能技术 | 2篇 |
自动化技术 | 36篇 |
出版年
2024年 | 2篇 |
2023年 | 5篇 |
2022年 | 21篇 |
2021年 | 27篇 |
2020年 | 20篇 |
2019年 | 27篇 |
2018年 | 29篇 |
2017年 | 39篇 |
2016年 | 26篇 |
2015年 | 14篇 |
2014年 | 25篇 |
2013年 | 27篇 |
2012年 | 17篇 |
2011年 | 19篇 |
2010年 | 12篇 |
2009年 | 3篇 |
2008年 | 8篇 |
2007年 | 4篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 1篇 |
1989年 | 2篇 |
1982年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
排序方式: 共有353条查询结果,搜索用时 15 毫秒
71.
Hang-Soo Park Rishi Man Chugh Melissa R. Pergande Esra Cetin Hiba Siblini Sahar Esfandyari Stephanie M. Cologna Ayman Al-Hendy 《International journal of molecular sciences》2022,23(9)
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-aged women, and it typically involves elevated androgen levels. Recently, it has been reported that human bone marrow mesenchymal stem cells (hBM-MSCs) can regulate androgen synthesis pathways. However, the details of the mechanism are still unclear. hBM-MSC-derived secreted factors (the secretome) are promising sources of cell-based therapy as they consist of various types of proteins. It is thus important to know which proteins interact with disease-implicated biomolecules. This work aimed to investigate which secretome components contain the key factor that inhibits testosterone synthesis. In this study, we fractionated hBM-MSC-conditioned media into three fractions based on their molecular weights and found that, of the three fractions, one had the ability to inhibit the androgen-producing genes efficiently. We also analyzed the components of this fraction and established a protein profile of the hBM-MSC secretome, which was shown to inhibit androgen synthesis. Our study describes a set of protein components present in the hBM-MSC secretome that can be used therapeutically to treat PCOS by regulating androgen production for the first time. 相似文献
72.
The increasing demand on execution of large-scale Cloud workflow applications which need a robust and elastic computing infrastructure usually lead to the use of high-performance Grid computing clusters. As the owners of Cloud applications expect to fulfill the requested Quality of Services (QoS) by the Grid environment, an adaptive scheduling mechanism is needed which enables to distribute a large number of related tasks with different computational and communication demands on multi-cluster Grid computing environments. Addressing the problem of scheduling large-scale Cloud workflow applications onto multi-cluster Grid environment regarding the QoS constraints declared by application’s owner is the main contribution of this paper. Heterogeneity of resource types (service type) is one of the most important issues which significantly affect workflow scheduling in Grid environment. On the other hand, a Cloud application workflow is usually consisting of different tasks with the need for different resource types to complete which we call it heterogeneity in workflow. The main idea which forms the soul of all the algorithms and techniques introduced in this paper is to match the heterogeneity in Cloud application’s workflow to the heterogeneity in Grid clusters. To obtain this objective a new bi-level advanced reservation strategy is introduced, which is based upon the idea of first performing global scheduling and then conducting local scheduling. Global-scheduling is responsible to dynamically partition the received DAG into multiple sub-workflows that is realized by two collaborating algorithms: (1) The Critical Path Extraction algorithm (CPE) which proposes a new dynamic task overall critically value strategy based on DAG’s specification and requested resource type QoS status to determine the criticality of each task; and (2) The DAG Partitioning algorithm (DAGP) which introduces a novel dynamic score-based approach to extract sub-workflows based on critical paths by using a new Fuzzy Qualitative Value Calculation System to evaluate the environment. Local-scheduling is responsible for scheduling tasks on suitable resources by utilizing a new Multi-Criteria Advance Reservation algorithm (MCAR) which simultaneously meets high reliability and QoS expectations for scheduling distributed Cloud-base applications. We used the simulation to evaluate the performance of the proposed mechanism in comparison with four well-known approaches. The results show that the proposed algorithm outperforms other approaches in different QoS related terms. 相似文献
73.
Sahar Sajjadi Milani Mahdi Ghassemi Kakroudi Nasser Pourmohammadie Vafa Sanaz Rahro Fatemeh Behboudi 《Ceramics International》2021,47(4):4813-4819
Magnesium aluminate (MgAl2O4) spinel precursor sol was prepared using aluminum nitrate and magnesium nitrate as the precursors for alumina and magnesia, respectively. The obtained sol owned a translucent, homogenous, and stable appearance with a density of 1.19 g/cm3, and at the temperatures above 60 °C, converted to a soft and clear gel. The measured pH of sol was in the range of 3–4, and at the calcination temperature of 1000 °C, the solid content of 6% was reached. TGA/DSC analysis was utilized to study the thermal behavior of the sol. Fourier transforms infrared spectroscopy (FTIR) was applied to recognize the existing bounds in the dried and calcined sol. X-ray diffraction patterns revealed the formation of single-phase MgAl2O4 up to 600 °C. According to the FESEM images, the grain size for the sol calcined at 1000 °C was estimated at around 50 nm. 相似文献
74.
Amin Javadifar Sahar Rastgoo Maciej Banach Tannaz Jamialahmadi Thomas P. Johnston Amirhossein Sahebkar 《International journal of molecular sciences》2021,22(5)
Atherosclerosis is a major cause of human cardiovascular disease, which is the leading cause of mortality around the world. Various physiological and pathological processes are involved, including chronic inflammation, dysregulation of lipid metabolism, development of an environment characterized by oxidative stress and improper immune responses. Accordingly, the expansion of novel targets for the treatment of atherosclerosis is necessary. In this study, we focus on the role of foam cells in the development of atherosclerosis. The specific therapeutic goals associated with each stage in the formation of foam cells and the development of atherosclerosis will be considered. Processing and metabolism of cholesterol in the macrophage is one of the main steps in foam cell formation. Cholesterol processing involves lipid uptake, cholesterol esterification and cholesterol efflux, which ultimately leads to cholesterol equilibrium in the macrophage. Recently, many preclinical studies have appeared concerning the role of non-encoding RNAs in the formation of atherosclerotic lesions. Non-encoding RNAs, especially microRNAs, are considered regulators of lipid metabolism by affecting the expression of genes involved in the uptake (e.g., CD36 and LOX1) esterification (ACAT1) and efflux (ABCA1, ABCG1) of cholesterol. They are also able to regulate inflammatory pathways, produce cytokines and mediate foam cell apoptosis. We have reviewed important preclinical evidence of their therapeutic targeting in atherosclerosis, with a special focus on foam cell formation. 相似文献
75.
Alawadi Khaled Khaleel Sahar Benkraouda Ouafa 《Journal of Housing and the Built Environment》2021,36(2):487-520
Journal of Housing and the Built Environment - Although Abu Dhabi and Dubai have similar political and planning systems, the two cities’ neighborhoods feature different morphological layouts.... 相似文献
76.
Silicon - A novel poly(acrylamide)/ clay mineral composite was synthesized by controlled radical polymerization of acrylamide, clay minerals using potassium persulfate (KPS) and N,... 相似文献
77.
Sahar Esfandyari Hoda Elkafas Rishi Man Chugh Hang-soo Park Antonia Navarro Ayman Al-Hendy 《International journal of molecular sciences》2021,22(4)
Cell–cell communication is an essential mechanism for the maintenance and development of various organs, including the female reproductive system. Today, it is well-known that the function of the female reproductive system and successful pregnancy are related to appropriate follicular growth, oogenesis, implantation, embryo development, and proper fertilization, dependent on the main regulators of cellular crosstalk, exosomes. During exosome synthesis, selective packaging of different factors into these vesicles happens within the originating cells. Therefore, exosomes contain both genetic and proteomic data that could be applied as biomarkers or therapeutic targets in pregnancy-associated disorders or placental functions. In this context, the present review aims to compile information about the potential exosomes with key molecular cargos that are dysregulated in female reproductive diseases which lead to infertility, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), Asherman syndrome, endometriosis, endometrial cancer, cervical cancer, ovarian cancer, and preeclampsia, as well as signaling pathways related to the regulation of the reproductive system and pregnancy outcome during these pathological conditions. This review might help us realize the etiology of reproductive dysfunction and improve the early diagnosis and treatment of the related complications. 相似文献
78.
BACKGROUND: Salmeterol xinafoate is a highly selective beta2-adrenoceptor for the maintenance treatment of asthma in adults and children. OBJECTIVE: To review the pharmacokinetics, clinical pharmacology, and therapeutic properties of a recently introduced, long acting antiasthmatic drug. METHODS: Recent English-language publications were selected using Medline as database. RESULTS: Salmeterol's pharmacokinetics, clinical pharmacology, and therapeutic properties are reviewed and aspects related to salmeterol's unusual duration of action, its high potency, beta2-selectivity, possible antiinflammatory actions, its interaction with other drugs, low systemic adverse effects, dosage, and administration are also discussed. CONCLUSION: Salmeterol is a safe long-acting beta2-agonist very useful for maintenance treatment of asthma. 相似文献
79.
Idwan Sahar Mahmood Imran Zubairi Junaid Ahmed Matar Izzeddin 《Wireless Personal Communications》2020,110(1):485-501
Wireless Personal Communications - Smart cities are benefiting from Internet of Things (IoT) in optimizing their services. Smart waste management systems can provide substantial savings in time,... 相似文献
80.
Matiullah Khan Zeng Yi Sahar Ramin Gul Yongzhe Wang U. Fawad 《Journal of Materials Science》2017,52(10):5634-5640
Optimized doped TiO2 is necessary for efficient visible light harvesting and widening the applications spectrum of TiO2-based materials. Titanium dioxide doped with silver and/or vanadium has been synthesized by one-pot hydrothermal method without post-calcination. Codoping induced visible light absorption while maintaining the photoactive anatase phase along with good crystallinity. Synthesized products are in nanometer range and possess high specific surface area. Having nearly spherical morphology, the particles are distributed and the particle size estimated from TEM observation is in accordance with the XRD results. Spectroscopic investigations reveal that the doped atoms successfully entered the TiO2 lattice modifying the band structure. The narrowed band gap allows visible light photons for absorption, and the codoped samples displayed enhanced visible light absorption among the synthesized samples. Photodegradation performance evaluated under visible light irradiations showed that silver- , vanadium-codoped TiO2 have the best visible light photocatalytic activity attributed to stable configuration, high visible light absorption, coupling between silver and vanadium and their optimal doping concentration. 相似文献