A novel electrical-mobility-based instrument for total number concentration measurements of ultrafine particles

A novel electrical-mobility-based technique to measure total particle number concentration over a selected size range is presented. Charged particles are condensed out onto an electrode that is shaped such that the product of its transfer function and the particle charging efficiency is a constant, independent of particle size. The resulting total current is then proportional to the number concentration of the sampled particles over the collected size range. The theoretical approach for the calculation of the electrode shape function is described. The extension of this technique for measurement of higher moments of the particle size distributions over a desired size range is briefly discussed.This concept is used to design a new instrument, called the tailored electrode concentration sensor (TECS). For validation of the theoretical concept, the collection electrode in the TECS instrument is designed for concentration measurements over a size range of 30–90 nm. In the TECS, the collection section is located downstream of an electrostatic precipitator section, where the sampled flow is split into aerosol and sheath flows, similar to the design of the MEAS [Ranjan, M., & Dhaniyala, S., (2007), Theory and design of a new miniature electrical-mobility aerosol spectrometer, Journal of Aerosol Science, 38(9), 950–963]. This results in a compact, low pressure drop instrument. Experimental results confirm that the response of the optimally-shaped electrode in the TECS system is only proportional to total number concentration over the selected size range.     

An Efficient and Scalable Quasi-Aggregate Signature Scheme Based on LFSR Sequences

Aggregate signatures can be a crucial building block for providing scalable authentication of a large number of users in several applications like building efficient certificate chains, authenticating distributed content management systems, and securing path vector routing protocols. Aggregate signatures aim to prevent resources (signature and storage elements, and computation) from growing linearly in the number of signers participating in a network protocol. In this paper, we present an efficient and scalable quasi-aggregate signature scheme, {rm CLFSR}- {rm QA}, based on third-order linear feedback shift register (cubic LFSR) sequences that can be instantiated using both XTR and GH public key cryptosystems. In the proposed {rm CLFSR}-{rm QA} construction, signers sign messages sequentially; however, the verfier need not know the order in which messages were signed. The proposed scheme offers constant length signatures, fast signing, aggregation, and verification operations at each node, and requires the least storage elements (public keys needed to verify the signature), compared to any other aggregate signature scheme. To the best of our knowledge, {rm CLFSR}- {rm QA} is the first aggregate signature scheme to be constructed using LFSR sequences. We believe that the {rm CLFSR}- {rm QA} signature scheme can be catalytic in improving the processing latency as well as reducing space requirements in building secure, large-scale distributed network protocols. We perform extensive theoretical analysis including correctness and security of {rm CLFSR}- {rm QA} and also present a performance (computation and communication costs, storage overhead) comparison of the proposed scheme with well-known traditional constructions.     

Validating for Liveness in Hidden Adversary Systems

Multi-stream interactive systems can be seen as “hidden adversary” systems (HAS), where the observable behaviour on any interaction channel is affected by interactions happening on other channels. One way of modelling HAS is in the form of a multi-process I/O automata, where each interacting process appears as a token in a shared state space. Constraints in the state space specify how the dynamics of one process affects other processes. We define the “liveness criterion” of each process as the end objective to be achieved by the process. The problem now for each process is to achieve this objective in the face of unforeseen interferences from other processes. In an earlier paper, it was proposed that this uncertainty can be mitigated by collaboration among the disparate processes. Two types of collaboration philosophies were also suggested: altruistic collaboration and pragmatic collaboration. This paper addresses the HAS validation problem where processes collaborate altruistically.     

Development of pitch-based carbon–copper composites

Carbon–copper composites with varying copper to carbon ratio of 0.66–1.5 (by weight) were developed from coal-tar-pitch-derived green coke (as such or modified with natural graphite) as carbon source and electrolytic grade copper powder at different heat treatment temperatures (HTTs) of 1000–1400 °C. The physical, mechanical, and electrical properties differ depending upon the HTT and also on copper to carbon ratio (Cu/C). The composites prepared at HTT of 1100 °C having Cu/C ratio of 0.66 and 0.9 exhibited a high bending strength of 150 and 140 MPa, bulk density of 2.63 and 2.81 gm/cm³, electrical resistivity of 1.6 and 0.96 m Ω cm and shore hardness of 88 and 84, respectively, in spite of well-known inadequate wettability between copper and carbon. Increasing the temperature from 1100 °C for processing of the composites deteriorated the properties mainly due to the loss of copper through melting above 1100 °C as revealed by X-ray, scanning electron microscopy, thermal analysis and EDAX studies.     

Efficient parallel algorithms for solvent accessible surface areaof proteins

We present faster sequential and parallel algorithms for computing the solvent accessible surface area (ASA) of protein molecules. The ASA is computed by finding the exposed surface areas of the spheres obtained by increasing the van der Waals radii of the atoms with the van der Waals radius of the solvent. Using domain specific knowledge, we show that the number of sphere intersections is only O(n), where n is the number of atoms in the protein molecule. For computing sphere intersections, we present hash-based algorithms that run in O(n) expected sequential time and O(n/p) expected parallel time and sort-based algorithms that run in worst-case O(n log n) sequential time and O(n log n/p) parallel time. These are significant improvements over previously known algorithms which take O(n²) time sequentially and O(n²/p) time in parallel. We present a Monte Carlo algorithm for computing the solvent accessible surface area. The basic idea is to generate points uniformly at random on the surface of spheres obtained by increasing the van der Waals radii of the atoms with the van der Waals radius of the solvent molecule and to test the points for accessibility. We also provide error bounds as a function of the sample size. Experimental verification of the algorithms is carried out using an IBM SP-2     

Glass fibre reinforced composites of triglycidyl-p-aminophenol

Glass fibre reinforced epoxy composites were fabricated from the matrix resins diglycidyl ether of bisphenol A (DGEBA) and triglycidyl-p-aminophenol (TGAP) using diethylene triamine as curing agent. The epoxy laminates were evaluated for their mechanical properties, dielectrical properties and chemical resistance. Significant improvement in fiexural strength but a slight deterioration in dielectrical properties were observed on incorporation of an epoxy fortifier into the resin system before fabricating the composites.     

A numerical study of pulsatile blood flow in an eccentric catheterized artery using a fast algorithm

The pulsatile blood flow in an eccentric catheterized artery is studied numerically by making use of an extended version of the fast algorithm of Borges and Daripa [J. Comp. Phys., 2001]. The mathematical model involves the usual assumptions that the arterial segment is straight, the arterial wall is rigid and impermeable, blood is an incompressible Newtonian fluid, and the flow is fully developed. The flow rate (flux) is considered as a periodic function of time (prescribed). The axial pressure gradient and velocity distribution in the eccentric catheterized artery are obtained as solutions of the problem. Through the computed results on axial pressure gradient, the increases in mean pressure gradient and frictional resistance in the artery due to catheterization are estimated. These estimates can be used to correct the error involved in the measured pressure gradients using catheters.     

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

Treatments utilizing monoclonal antibody therapeutics against intracellular protein-protein interactions in cancer cells have been hampered by several factors, including poor intracellular uptake and rapid lysosomal degradation. Our current work examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. Nanoparticles were formulated and then characterized using a number of physical and biological parameters. The average nanoparticle size ranged from 221 to 252 nm with a low polydispersity index. Encapsulation efficiency of 16%–22% and antibody loading of 0.3%–1.12% were observed. The antibody molecules were released from the nanoparticles in a sustained manner and upon release maintained functionality. Our studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.     

A slow wave structure and its application in bandpass filter design

This paper presents a new slow wave open-loop resonator filters with reduced size and improved stopband characteristics. A comprehensive treatment of different kind of coupling in this structure is demonstrated. Two and four resonator band pass filters at center frequency 2.15 and 2.30 GHz with different bandwidth are designed. The simulated results are verified with the help of two different software packages (IE3D and Sonnet Lite).     

Role of V2O5 on the formation of chemical mullite from aluminosilicate precursor

Aluminosilicate precursor for the processing of mulite ceramics was synthesized chemically from inorganic salts following colloidal route. V₂O₅ was used as a sintering additive in different ratios with the precursor powder. The powder mixes were compacted and sintered at different elevated temperatures. The sintered masses were characterized by measuring the bulk density, porosity, flexural strength and fracture toughness. The extent of mullitization and final microstructure of the sintered masses were investigated by scanning electron microscopy and XRD analysis. It was observed that V₂O₅ exhibited favourable effect on the formation of properly crystallized mullite and in the improvement of different mechanical properties.