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231.
Abstraction layers for scalable microfluidic biocomputing 总被引:2,自引:0,他引:2
William Thies John Paul Urbanski Todd Thorsen Saman Amarasinghe 《Natural computing》2008,7(2):255-275
Microfluidic devices are emerging as an attractive technology for automatically orchestrating the reactions needed in a biological
computer. Thousands of microfluidic primitives have already been integrated on a single chip, and recent trends indicate that
the hardware complexity is increasing at rates comparable to Moore’s Law. As in the case of silicon, it will be critical to
develop abstraction layers—such as programming languages and Instruction Set Architectures (ISAs)—that decouple software development
from changes in the underlying device technology. Towards this end, this paper presents BioStream, a portable language for
describing biology protocols, and the Fluidic ISA, a stable interface for microfluidic chip designers. A novel algorithm translates
microfluidic mixing operations from the BioStream layer to the Fluidic ISA. To demonstrate the benefits of these abstraction
layers, we build two microfluidic chips that can both execute BioStream code despite significant differences at the device
level. We consider this to be an important step towards building scalable biological computers.
相似文献
Saman AmarasingheEmail: |
232.
The control problem of trajectory based path following for passenger vehicles is studied. Comprehensive nonlinear vehicle model is utilized for simulation vehicle response during various maneuvers in MATLAB/Simulink. In order to follow desired path, a driver model is developed to enhance closed loop driver/vehicle model. Then, linear quadratic regulator(LQR) controller is developed which regulates direct yaw moment and corrective steering angle on wheels. Particle swam optimization(PSO) method is utilized to optimize the LQR controller for various dynamic conditions. Simulation results indicate that, over various maneuvers, side slip angle and lateral acceleration can be reduced by 10% and 15%, respectively, which sustain the vehicle stable. Also, anti-lock brake system is designed for longitudinal dynamics of vehicle to achieve desired slip during braking and accelerating. Proposed comprehensive controller demonstrates that vehicle steerability can increase by about 15% during severe braking by preventing wheel from locking and reducing stopping distance. 相似文献
233.
234.
Saman Amarasinghe Michael l. Gordon Michal Karczmarek Jasper Lin David Maze Rodric M. Rabbah William Thies 《International journal of parallel programming》2005,33(2-3):261-278
High-performance streaming applications are a new and distinct domain of programs that is increasingly important. The StreamIt language provides novel high-level representations to improve programmer productivity and program robustness within the streaming domain. At the same time, the StreamIt compiler aims to improve the performance of streaming applications via stream-specific analysis and optimizations. In this paper, we motivate, describes and justify the StreamIt language which include a structured model of streams, a messaging system for control, and a natural textual syntax. 相似文献
235.
F. Rais A. Kamoun M. Chaabouni M. Claeys-Bruno R. Phan-Tan-Luu M. Sergent 《Chemometrics and Intelligent Laboratory Systems》2009,99(1):71-78
In a previous paper, we showed that the preparation of sulfated diethanolamide of fatty acids is easy to carry out without organic solvents when using olive pomace oil as starting material; the reaction yield was, however, highly variable as a function of factor levels. The purpose of this research is to look for the optimal experimental conditions. We started by applying a supersaturated experimental design to screen for important factors among a list of 31 potentially influential factors in 18 experiments. Thus, we constructed a two-level supersaturated design as a half fraction of a 36-experiment Hadamard matrix and used it for this screening purpose. Multiple regression methods namely stepwise selection procedure, ridge regression and all-subset regressions were used to analyze the supersaturated design results according to a four step procedure. Results indicated that six factors, namely, molar ratio SO3/ester, amidation time, amide addition rate, alkali reagent, alkali concentration, and amidation temperature, were very influential factors. Three other factors were moderately influential: neutralization temperature, sodium methanoate amount, and methanol amount. In future research, these factors will be further studied in order to perform robustness tests of the process. 相似文献
236.
This paper presents the results of a thermal performance analysis of a phase change thermal storage unit. The unit consists of several parallel flat slabs of phase change material (PCM) with a liquid heat transfer fluid (HTF) flowing along the passages between the slabs. A validated numerical model developed previously to solve the phase change problem in flat slabs was used. An insight is gained into the melting process by examining the temperatures of the HTF nodes, wall nodes and PCM nodes and the heat transfer rates at four phases during melting. The duration of the melting process is defined based on the level of melting completion. The effects of several parameters on the HTF outlet temperature, heat transfer rate and melting time are evaluated through a parametric study to evaluate the effects of the HTF mass flow rate, HTF inlet temperature, gap between slabs, slab dimensions, PCM initial temperature and thermal conductivity of the container on the thermal performance. The results are used to design a phase change thermal storage unit for a refrigerated truck. 相似文献
237.
In this paper, a fracture mechanic approach is used to analyze delamination propagation between layers of composite laminates. A finite element method based on layer-wise theory is extended for the analysis of delamination growth. In this approach, delamination is modeled by jump discontinuity conditions at the interfaces. The layer-wise finite element is developed to calculate the strain energy release rates based on the virtual crack closure technique (VCCT). A procedure is proposed to handle the progressive delamination of laminates. Finally, analyses of the edge delamination propagation for several composite laminates are performed and the corresponding failure stresses are calculated. The predicted results are compared with the available experimental and numerical results. It is shown that the predicted failure stresses using this method are comparable with those obtained using interface elements. 相似文献
238.
R Rabii H Rais M Hafiani BE Dassouli S Bennani M el Mrini S Benjelloun 《Canadian Metallurgical Quarterly》1998,32(1):49-51
A pregnant woman was found to have severe hypertriglyceridemia, fasting chylomicronemia, and low platelet count. The activities of serum lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) proved to be extremely low. The activities of the enzymes in normal plasma were completely inhibited by addition of the patient's plasma. We concluded that autoantibodies to lipases were responsible for this patient's hypertriglyceridemia. 相似文献
239.
Iris-based biometric systems identify individuals based on the characteristics of their iris, since they are proven to remain unique for a long time. An iris recognition system includes four phases, the most important of which is preprocessing in which the iris segmentation is performed. The accuracy of an iris biometric system critically depends on the segmentation system. In this paper, an iris segmentation system using edge detection techniques and Hough transforms is presented. The newly proposed edge detection system enhances the performance of the segmentation in a way that it performs much more efficiently than the other conventional iris segmentation methods. 相似文献
240.
Orouji T Hosseini Pooya SM Jafarizadeh M Khosravi HR Rais Mohammad H 《Radiation protection dosimetry》2011,147(1-2):227-229
The X-ray body scanner (BS) is going to find common use as a body-checking equipment at the entrance borders of countries, to find illicit drugs or forbidden items which have been hidden inside the body cavities, or attached to the body parts of the passengers. Considering the tissue weighting factors of the sensitive organs, the total effective dose due to the scanning by the system was estimated to be 3.8 μSv per scan. The ambient dose equivalent rates within the distance range of 300-40 cm from the X-ray generator were measured to be 4.5 up to 50 μSv h(-1). It is concluded that, in general, BS systems could be a safe device for the operators and people who are being scanned. But using such systems should be justified for everybody and special care should be taken for children and pregnant ladies. 相似文献