Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Layered hydroxide nanoparticles are generally biocompatible, and less toxic than most inorganic nanoparticles, making them an acceptable alternative drug delivery system. Due to growing concern over animal welfare and the expense of in vivo experiments both the public and the government are interested to find alternatives to animal testing. The toxicity potential of zinc aluminum layered hydroxide (ZAL) nanocomposite containing anti-Parkinsonian agent may be determined using a PC 12 cell model. ZAL nanocomposite demonstrated a decreased cytotoxic effect when compared to levodopa on PC12 cells with more than 80% cell viability at 100 μg/mL compared to less than 20% cell viability in a direct levodopa exposure. Neither levodopa-loaded nanocomposite nor the un-intercalated nanocomposite disturbed the cytoskeletal structure of the neurogenic cells at their IC₅₀ concentration. Levodopa metabolite (HVA) released from the nanocomposite demonstrated the slow sustained and controlled release character of layered hydroxide nanoparticles unlike the burst uptake and release system shown with pure levodopa treatment.     

Non-uniform illumination in concentrating solar cells

After a gap of more than two decades, Concentrator Photovoltaics (CPV) technology is once again under spotlight for making use of the best available solar cell technologies and improving the overall performance. CPV finds its use in a number of applications ranging from building integration to huge power generation units. Although the principles of solar concentration are well understood, many practical design, operation, control issues require further understanding and research. A particular issue for CPV technology is the non-uniformity of the incident flux which tends to cause hot spots, current mismatch and reduce the overall efficiency of the system. Understanding of this effect requires further research, and shall help to employ the most successful means of using solar concentrators. This study reviews the causes and effects of the non-uniformity in the CPV systems. It highlights the importance of this issue in solar cell design and reviews the methods for the solar cell characterization under non-uniform flux conditions. Finally, it puts forward a few methods of improving the CPV performance by reducing the non-uniformity effect on the concentrator solar cells.     

Steam reforming of methanol over ruthenium impregnated ceria,alumina and ceria–alumina catalysts

The wet impregnation method was used to prepare different ruthenium promoted Ce–Al catalysts. These catalysts were used in the steam reforming of methanol reaction (SRM). The effects of the reaction temperature (200–400 C) and the catalyst composition were studied for optimization reasons. The steam to methanol molar ratio was kept constant (S/M = 2). The promotion of cerium/aluminum oxides with Ru enhanced their catalytic activity. The catalytic test results showed that the Ru/Ce combination was the most beneficial. The synergy between Ru and cerium oxide led to the formation of active sites with excellent redox properties. For high active phase content, the 5 RuCe catalyst exhibited the highest hydrogen production amount with no CO formation. This catalyst was kept under stream for 5 days at 400 C, and no significant deactivation was observed. Copyright © 2016 John Wiley & Sons, Ltd.     

Multi carrier energy systems and energy hubs: Comprehensive review,survey and recommendations

In this paper, the multi carrier energy (MCE) systems are reviewed from different point of views including mathematical models, integrated components and technologies, uncertainty management, planning objectives, environmental pollution, resilience, and robustness. The basic of MCE systems is formed by combination of cooling, heating and power (CCHP). The natural gas and electricity are the main inputs to MCE systems and the cooling, heating, and electricity are the common outputs. The regular energy converters in the MCE systems are combined heat and power (CHP), gas boiler, absorption-electrical chillers, power to gas (P2G) and fuel-cell. The generic energy storages are electrical, heating, cooling, hydrogen, carbon dioxide (CO₂) and hydro systems.     

Sign Language to Sentence Formation: A Real Time Solution for Deaf People

Communication is a basic need of every human being to exchange thoughts and interact with the society. Acute peoples usually confab through different spoken languages, whereas deaf people cannot do so. Therefore, the Sign Language (SL) is the communication medium of such people for their conversation and interaction with the society. The SL is expressed in terms of specific gesture for every word and a gesture is consisted in a sequence of performed signs. The acute people normally observe these signs to understand the difference between single and multiple gestures for singular and plural words respectively. The signs for singular words such as I, eat, drink, home are unalike the plural words as school, cars, players. A special training is required to gain the sufficient knowledge and practice so that people can differentiate and understand every gesture/sign appropriately. Innumerable researches have been performed to articulate the computer-based solution to understand the single gesture with the help of a single hand enumeration. The complete understanding of such communications are possible only with the help of this differentiation of gestures in computer-based solution of SL to cope with the real world environment. Hence, there is still a demand for specific environment to automate such a communication solution to interact with such type of special people. This research focuses on facilitating the deaf community by capturing the gestures in video format and then mapping and differentiating as single or multiple gestures used in words. Finally, these are converted into the respective words/sentences within a reasonable time. This provide a real time solution for the deaf people to communicate and interact with the society.     

Partial replacement of sodium chloride with potassium chloride in marinated rabbit meat

This study was aimed at evaluating the consequences of sodium chloride reduction by potassium chloride up to 50% on technological, sensorial and microbiological traits of marinated rabbit meat. In total, 226 rabbit loin meat samples were obtained and subjected to vacuum tumbling using solutions with different NaCl/KCl ratios. Replacing of sodium chloride up to 30% by potassium chloride did not change microbiological traits (total aerobic mesophilic and lactic acid bacteria maximum cell loads), sensorial acceptability (perceived saltiness and overall liking) and technological traits (pH, colour, texture, cooking loss and yield). Otherwise, reduction in sodium chloride to 50% significantly decreased perceived saltiness (4.15 vs. 4.73; P < 0.05) and reduced microbial shelf life by 1 day when compared to control, even if there was still no effect on technological traits. In conclusion, it is feasible imparting an added value for processed rabbit meat products by reduction in sodium content that could increase market interest.