Application of a Coordination Model for a Large Number of Stakeholders with a New Game Theory Model

Water Resources Management - Water allocation is an important issue for systems with multiple stakeholders. Individual and collective decisions are very important for such systems. Thus, a new...     

Biodegradable and conductive hyperbranched terpolymers based on aliphatic polyester,poly(D,L-lactide), and polyaniline used as scaffold in tissue engineering

Designing the novel conductive and biodegradable scaffolds based on star-like hyperbranched terpolymers of aliphatic polyester–poly(D,L-lactide)–polyaniline (S-HAP–PLA–PANI) was the purpose of this research. The electroactivity of tissue engineering scaffold, which in the current work was for the presence of PANI, is an essential factor in its performance because the electrical signals are the pivotal physiological stimuli that control the adhesion and differentiation of various cell types. Star-shaped polymers have attracted conspicuous attention, thanks to their low-cost, well-defined highly functionalized structures and low crystallinity, and they also could be an interesting alternative to the linear analogs for their interaction with surrounding tissue and faster degradation rate. In the present work, after 12 weeks, the mass loses for S-HAP–PLA–PANI sample were calculated to be 45%. Scaffolds based on S-HAP–PLA–PANI/PLA nanofibers having the average diameter of 70–200?nm and electrical conductivity of 0.05 S cm^?1 imitated the natural microenvironment of extra cellular matrix to regulate the cell attachment, proliferation, and differentiation.     

Role of parietal and principal gastric mucosa cells in the phenomenon of concentration of aluminum and indium

The subcellular behavior of aluminum and indium, used in medical and industrial fields, was studied in the gastric mucosa and the liver after their intragastric administration to rats, using, two of the most sensitive methods of observation and microanalysis, the transmission electron microscopy, and the secondary ion mass spectrometry. The ultrastructural study showed the presence of electron dense deposits, in the lysosomes of parietal and principal gastric mucosa cells but no loaded lysosomes were observed in the different studied hepatic territories. The microanalytical study allowed the identification of the chemical species present in those deposits as aluminum or indium isotopes and the cartography of their distribution. No modification was observed in control rats tissues. In comparison to previous studies describing the mechanism of aluminum concentration in the gastric mucosa and showing that this element was concentrated in the lysosomes of fundic and antral human gastric mucosa, our study provided additional informations about the types of cells involved in the phenomenon of concentration of aluminum and indium, which are the parietal and the principal cells of the gastric mucosa. Our study demonstrated that these cells have the ability to concentrate selectively aluminum and indium in their lysosomes, as a defensive reaction against intoxication by foreign elements.     

Development of nano-channel single crystals and verification of their structures by small angle X-ray scattering

Nano-channel single crystals were developed via consecutive growth of various polymer single-crystal channels comprising homo and block copolymers by self-seeding method. Poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(methyl methacrylate) (PEG-b-PMMA) block copolymers were synthesized by atom transfer radical polymerization. Self-seeding temperature, concentration, and crystallization time affected the width of the channels. This might provide a new way to investigate directional absorption, diffusion, and immobilization of biomacromolecules on the surface. The crystalline blocks of PEG-b-PS and PEG-b-PMMA diblock copolymers were similar, therefore, the continuity of channel-wire growth was guaranteed. Development of complete square channels next to the channels covered with high molecular weight brushes was infeasible. It was ascribed to a higher hindrance of primarily existing tethered chains on the single-crystal channel. Finally, the consecutive channel-wire single crystals were compared with single-step-grown pyramidal and conic structures. These multilayer crystals grew spirally and formed non-flat channels. The structure and morphology of different crystalline channels were detected by atomic force microscopy (AFM) and small angle X-ray scattering (SAXS). In this work, for the first time, the SAXS data of channel-wire single crystals were reported and they were compared by non-flat channel-like crystals. A profound investigation of PEG-b-PS, PEG-b-PMMA copolymers and PEG homopolymer channel-wire single crystals by SAXS and their comparison with AFM data was a novel work in the field of single-crystal engineering.     

Causes and consequences of desertification in Kuwait: a case study of land degradation

Desertification in Kuwait is a process of environmental degradation under fragile ecological conditions and intensive human activities and the consequences of Gulf War. In Kuwait, very severe desertification prevails, due to increasing formation of new active sandy bodies, deterioration of many areas of natural vegetation cover to less than 10%, and limited water resources for large-scale forage production. Average annual desertified land in Kuwait is estimated to be 285 km². In Kuwait, three indicators of land degradation are encountered. These are vegetation, soil, and surface hydrological changes. Based on field measurements of soil compaction and vegetation changes, in the west Jahra area in the northern part of the country, degradation levels were assessed. Results of these measurements show that the average infiltration rate in compacted soil decreased by 53.8% in comparison with non-compacted soil, while the average soil penetration resistance in compacted soil increased by 154.1% in comparison with non-compacted soil. The bulk density in open sites was 23.4% higher than that in protected sites. The percentage of litter in open sites decreased by 77.3% in comparison with protected sites, while the percentage of total vegetation in open sites decreased by 6.1% in comparison with protected sites. Electronic Publication     

A Survey of Autoencoder Algorithms to Pave the Diagnosis of Rare Diseases

Rare diseases (RDs) concern a broad range of disorders and can result from various origins. For a long time, the scientific community was unaware of RDs. Impressive progress has already been made for certain RDs; however, due to the lack of sufficient knowledge, many patients are not diagnosed. Nowadays, the advances in high-throughput sequencing technologies such as whole genome sequencing, single-cell and others, have boosted the understanding of RDs. To extract biological meaning using the data generated by these methods, different analysis techniques have been proposed, including machine learning algorithms. These methods have recently proven to be valuable in the medical field. Among such approaches, unsupervised learning methods via neural networks including autoencoders (AEs) or variational autoencoders (VAEs) have shown promising performances with applications on various type of data and in different contexts, from cancer to healthy patient tissues. In this review, we discuss how AEs and VAEs have been used in biomedical settings. Specifically, we discuss their current applications and the improvements achieved in diagnostic and survival of patients. We focus on the applications in the field of RDs, and we discuss how the employment of AEs and VAEs would enhance RD understanding and diagnosis.     

Intracellular behaviour of samarium and europium in lactating mammary gland

The subcellular localization of samarium and europium, two rare-earths, increasingly used in both medical and industrial fields, has been studied in several organs such as liver and kidney but never in the mammary gland despite of its importance in the biology of lactation and nutrition domains. The intracellular behaviour of samarium and europium after their intra-peritoneal administration in the lactating mammary gland cells was investigated. The results showed the presence of very electron dense deposits in the glandular epithelial cell lysosomes. These particular lysosomes were never observed in the mammary cell lysosomes of control rats. These intralysosomal deposits were probably composed of insoluble samarium or europium phosphates by analogy with previous studies, the transmission electron microscopy, the ion mass microscopy and the electron probe microanalysis, and other techniques allowing the identification of the chemical structure of the intralysosomal deposits.     

Combined effect of nanoporous diluent and steam on catalytic upgrading of fuel oil to olefins and fuels over USY catalyst

This paper explores the effect of incorporation of a nanoporous silica as diluent for a USY catalyst in the presence or absence of steam, as a cost-effective hydrogen donor and regenerative agent, in the fuel oil upgrading. We found that the incorporation of inert silica in the catalyst particles in the presence of steam could produce more than 40 wt% of olefinic products, mainly propylene, in the cracked products. With the elimination of steam, the olefins yield became less than a half (about 17 wt%) and the reaction tended towards higher liquid yields (74.8 wt%) including gasoline and diesel fuel.