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71.
Nelson James Byron; Sanjuan María del Carmen; Vadillo-Ruiz Sandra; Pérez Joana; León Samuel P. 《Canadian Metallurgical Quarterly》2011,37(1):58
Two experiments with human participants are presented that differentiate renewal from other behavioral effects that can produce a response after extinction. Participants played a video game and learned to suppress their behavior when sensor stimuli predicted an attack. Contexts (A, B, & C) were provided by fictitious galaxies where the game play took place. In Experiment 1, participants who received conditioning in A, extinction in B, and testing in A showed some context specificity of conditioning during extinction and a recovery of suppression on test. Experiment 2 demonstrated recovery of extinguished responding when participants were conditioned in A, extinguished in B, and tested in C, a third, neutral context. The experiment also demonstrated that the context of extinction did not control performance by becoming inhibitory. Results are discussed in terms of mechanisms that can produce a response recovery after extinction. The experiments demonstrated a renewal effect: a response recovery that was not attributable to the contexts acting as simple conditioned stimuli and is the first work with human participants to conclusively do so. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
72.
Samson Jerold Samuel Chelladurai Ramesh Arthanari Rohith Selvarajan Ramakrishnan Kanagaraj Palanisamy Angappan 《Transactions of the Indian Institute of Metals》2018,71(9):2221-2230
Copper coated steel fibers reinforced LM13 aluminium alloy composites have been prepared using stir casting process. Experiments have been designed using response surface methodology by varying wt% of reinforcement (0–10), stirrer speed (350–800 rpm) and pouring temperature (700–800 °C). Microstructure, tensile strength and fracture surface of composites have been investigated. Analysis of variance, significance test and confirmation tests have been performed and regressions models have been developed to predict the tensile strength of composites. Response surface plots reveal that tensile strength of composites increases with increasing wt% of copper coated steel fibers reinforcement up to 6 wt%. Further increase in wt% of steel fibers decreases the tensile strength of composites. However tensile strength of composites increases with increasing stirrer speed due to the uniform and homogeneous dispersion of steel fibers in matrix. Optimum stir cast process parameters for obtaining higher tensile strength are found to be 5.9 wt% of reinforcement, 753 °C pouring temperature and stirrer speed of 633 rpm. Fracture mechanism is dominated by steel fiber pullouts in composites with higher wt% of reinforcement and dimples are observed in the surface of composites containing lower levels of wt% of reinforcement. 相似文献
73.
Samuel J. Moseley Christine A. Allen Nicholas Costin Richard Kelley Caroline Kilbourne Timothy Miller 《Journal of Low Temperature Physics》2008,151(1-2):418-423
We have developed an automated die-scale process for the attachment of X-ray absorbers onto microcalorimeters. Here, we describe
the process for the production of absorber tiles on a handle wafer, their attachment to the microcalorimeter, and the removal
of the supporting handle wafer. The process is shown to be a robust path to large format arrays of microcalorimeters.
相似文献
74.
Bartasyte A Chaix-Pluchery O Kreisel J Santiso J Margueron S Boudard M Jiménez C Abrutis A Weiss F 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2007,54(12):2623-2631
A systematic study of domain structure and residual stress evolution with film thickness and of phase transition in c/a epitaxial PbTiO(3)/LaAlO(3) films using X-ray diffraction and Raman spectroscopy is reported. Both techniques revealed that the films are under tensile residual stress in the film plane and that a-domains are more stressed than c-domains. The two components of the large A(1)(TO) Ramanmodes are associated with a- and c-domains and their intensity ratio correlates to the volume fraction of a-domains. The evolution of the Raman signature with temperature revealed that the spectrum of a-domains disappears around 480 degrees C, whereas c-domains present an anomaly in their spectrum at 500 degrees C but maintain a well-defined Raman signature up to 600 degrees C. 相似文献
75.
Samuel Swearson Aseel O. Rataan Steven Eliason Brad A. Amendt Yousef Zakharia Aliasger K. Salem Thai Ho Youcef M. Rustum 《International journal of molecular sciences》2022,23(10)
This study was carried out to quantitate the expression levels of microRNA-17, -19a, -34a, -155, and -210 (miRs) expressed in nine clear cell renal cell carcinoma (ccRCC) and one chromophobe renal cell carcinoma cell line with and without sarcomatoid differentiation, and in six primary kidney tumors with matching normal kidney tissues. The data in the five non-sarcomatoid ccRCC cell lines—RC2, CAKI-1, 786-0, RCC4, and RCC4/VHL—and in the four ccRCC with sarcomatoid differentiation—RCJ41T1, RCJ41T2, RCJ41M, and UOK-127—indicated that miR-17 and -19a were expressed at lower levels relative to miR-34a, -155, and -210. Compared with RPTEC normal epithelial cells, miR-34a, miR-155, and miR-210 were expressed at higher levels, independent of the sarcomatoid differentiation status and hypoxia-inducible factors 1α and 2α (HIFs) isoform expression. In the one chromophobe renal cell carcinoma cell line, namely, UOK-276 with sarcomatoid differentiation, and expressing tumor suppressor gene TP53, miR-34a, which is a tumor suppressor gene, was expressed at higher levels than miR-210, -155, -17, and -19a. The pilot results generated in six tumor biopsies with matching normal kidney tissues indicated that while the expression of miR-17 and -19a were similar to the normal tissue expression profile, miR-210, -155, -and 34a were expressed at a higher level. To confirm that differences in the expression levels of the five miRs in the six tumor biopsies were statistically significant, the acquisition of a larger sample size is required. Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC. 相似文献
76.
Nora Bloise Erik I. Waldorff Giulia Montagna Giovanna Bruni Lorenzo Fassina Samuel Fang Nianli Zhang Jiechao Jiang James T. Ryaby Livia Visai 《International journal of molecular sciences》2022,23(13)
Polyetheretherketone (PEEK) titanium composite (PTC) is a novel interbody fusion device that combines a PEEK core with titanium alloy (Ti6Al4V) endplates. The present study aimed to investigate the in vitro biological reactivity of human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) to micro- and nanotopographies produced by an acid-etching process on the surface of 3D-printed PTC endplates. Optical profilometer and scanning electron microscopy were used to assess the surface roughness and identify the nano-features of etched or unetched PTC endplates, respectively. The viability, morphology and the expression of specific osteogenic markers were examined after 7 days of culture in the seeded cells. Haralick texture analysis was carried out on the unseeded endplates to correlate surface texture features to the biological data. The acid-etching process modified the surface roughness of the 3D-printed PTC endplates, creating micro- and nano-scale structures that significantly contributed to sustaining the viability of hBM-MSCs and triggering the expression of early osteogenic markers, such as alkaline phosphatase activity and bone-ECM protein production. Finally, the topography of 3D-printed PTC endplates influenced Haralick’s features, which in turn correlated with the expression of two osteogenic markers, osteopontin and osteocalcin. Overall, these data demonstrate that the acid-etching process of PTC endplates created a favourable environment for osteogenic differentiation of hBM-MSCs and may potentially have clinical benefit. 相似文献
77.
78.
79.
Ioannis Rekleitis Ai Peng New Edward Samuel Rankin Howie Choset 《Annals of Mathematics and Artificial Intelligence》2008,52(2-4):109-142
This paper presents algorithmic solutions for the complete coverage path planning problem using a team of mobile robots. Multiple robots decrease the time to complete the coverage, but maximal efficiency is only achieved if the number of regions covered multiple times is minimized. A set of multi-robot coverage algorithms is presented that minimize repeat coverage. The algorithms use the same planar cell-based decomposition as the Boustrophedon single robot coverage algorithm, but provide extensions to handle how robots cover a single cell, and how robots are allocated among cells. Specifically, for the coverage task our choice of multi-robot policy strongly depends on the type of communication that exists between the robots. When the robots operate under the line-of-sight communication restriction, keeping them as a team helps to minimize repeat coverage. When communication between the robots is available without any restrictions, the robots are initially distributed through space, and each one is allocated a virtually-bounded area to cover. A greedy auction mechanism is used for task/cell allocation among the robots. Experimental results from different simulated and real environments that illustrate our approach for different communication conditions are presented. 相似文献
80.
Yifang Li Sharon D. Ricardo Chrishan S. Samuel 《International journal of molecular sciences》2022,23(11)
Chronic kidney disease (CKD) affects 1 in 10 members of the general population, placing these patients at an increasingly high risk of kidney failure. Despite the significant burden of CKD on various healthcare systems, there are no effective cures that reverse or even halt its progression. In recent years, human bone-marrow-derived mesenchymal stromal cells (BM-MSCs) have been recognised as a novel therapy for CKDs, owing to their well-established immunomodulatory and tissue-reparative properties in preclinical settings, and their promising safety profile that has been demonstrated in patients with CKDs from several clinical trials. However, renal fibrosis (scarring), a hallmark of CKD, has been shown to impair the viability and functionality of BM-MSCs post-transplantation. This has suggested that BM-MSCs might require a pre-treatment or adjunct therapy that can enhance the viability and therapeutic efficacy of these stromal cells in chronic disease settings. To address this, recent studies that have combined BM-MSCs with the anti-fibrotic drug serelaxin (RLX), have demonstrated the enhanced therapeutic potential of this combination therapy in normotensive and hypertensive preclinical models of CKD. In this review, a critical appraisal of the preclinical data available on the anti-fibrotic and renoprotective actions of BM-MSCs or RLX alone and when combined, as a treatment option for normotensive vs. hypertensive CKD, is discussed. 相似文献