Age Replacement In Simple Systems With Increasing Loss Functions

Some age replacement policies are investigated and conditions for the unique existence of an optimum policy are derived. The optimum policy is the one which minimizes the expected cost per unit time over an infinite time span or maximizes the proportion of time during which the system is in operation. Losses have been expressed through increasing operating cost, if the objective is to minimize the expected total cost per unit time and through increasing renewal times if the objective is to maximize the availability of the system.     

Complex two-unit system with preventive maintenance

A two-unit warm standby redundant system with repair and preventive maintenance is considered. The pdf of the life time of a unit while in standby is assumed to be Erlangian. The pdfs of all the other random variables are arbitrary. Identifying suitable regeneration points, expressions for the Laplace transforms of the availability and reliability of the system are derived.     

The computer analysis of space frames with offset members

The problems involved in the analysis of three dimensional frames having offset prismatic members are investigated. The sources of offset considered are the rigid gusset plate effects and misalignment of members from specified joint positions. The secondary effects due to axial forces are also considered in the analysis. The displacement method of structural analysis is used with an iterative procedure to take into account the secondary effects. The complete stiffness matrix has been derived. The computer program developed, based on this analysis, is also explained. From the example of steel frame folded plate it is seen that the difference in maximum axial forces and bending moments due to the offset members are about 20%. It appears that the method, developed herein, for analysing space frames having offset members, offers a very direct and versatile approach to the problem of analysing structures having misaligned members.     

A study on the behaviour of steel braced barrel vaults

The computer analysis of steel braced barrel vaults is presented. This analysis is compared with the approximate method of analysis suggested by Baer. The drawbacks of Baer's method are discussed. The behaviour of these frames due to the effect of laterals, edge trusses and different types of bracing systems is predicted. Based on this parametric study an economic system of braced barrel vault is suggested for practical applications.     

Effect of lipid excipients on in vitro pancreatic lipase activity

PURPOSE: To study the effects of two lipid excipients, Peceol and Gelucire 44/14 on the in vitro pancreatic lipase activity. METHODS: A 50 microL reaction mixture, consisting of 45 microL (3H) triolein as the radiolabeled substrate, 2.5 microL Peceol or Gelucire 44/14 (0.05-0.5%), either alone or in combination, 2.5 microL colipase (100 microg/mL), and 2.5 microL pancreatic lipase (1 mg/mL), was incubated for 10 min at room temperature. At the end of incubation, the reaction was stopped by the addition of an extraction solvent containing chloroform, methanol, and n-heptane (12.5:14:10), and the mixture vortexed briefly. Subsequently, 250 microL of 50 mM sodium carbonate was added and the aqueous and organic phase separated by centrifugation for 5 min at 1000 g. One hundred microliters of the supernatant was transferred to a scintillation counter and then radioactivity measured after the addition of 3.6 mL of scintillation fluid. Pancreatic lipase activity was determined by measuring the amount of free fatty acid released into the incubation medium and expressed as micromol free fatty acid released/min. RESULTS: When used alone, Peceol inhibited the pancreatic lipase activity significantly in a concentration-dependent manner, with a maximum inhibition of 57% at 0.4% of the excipient [p < 0.05, one-way analysis of variance (ANOVA)]. Similarly, Gelucire 44/14 alone caused inhibition of lipase activity in a concentration-dependent manner. However, the maximum inhibition (30%) was smaller in magnitude compared with the former agent. When the two excipients were used in combination, the inhibitory effects on the enzyme activity were similar to those observed with the individual agents (p < 0.05, one-way ANOVA). However, the maximum inhibition of 30% was lower than that observed with Peceol alone. CONCLUSIONS: The results from this study suggest that these lipid excipients inhibit in vitro pancreatic lipase activity and should be taken into consideration when developing oral formulations using these agents.     

Effect of Mn on strain accumulation in Nb microalloying steels

High Mn is added in line pipe steels to strengthen them. Also, Mn lowers the phase transformation temperature, which is an advantage because it lowers the rolling temperature for grain size control. However, Mn retards the kinetics of precipitation of NbC in thermo-mechanical processing in Nb microalloying steels. In high-grade line pipe steels, the control of strain accumulation behavior is the key to the control of grain size. Strain accumulation can only be obtained when static recrystallization between passes could be suppressed. The effect of NbC precipitates on suppressing recrystallization has been widely investigated, mostly focusing on the Zener pinning of NbC on grain boundaries. However, it is applicable in large strain and long inter-pass time. In short inter-pass time, such as strip mill rolling, recrystallization behavior is controlled by the complicated interaction of precipitation with recovery and recrystallization. In this paper, the effect of Mn on strain accumulation during multi-pass strip mill rolling based on the interaction of precipitates with the activation energy of grain boundary migration and recovery, and the thermodynamics and kinetics of recrystallization are discussed systematically.     

Green synthesis of silver nanoparticles using Zea mays and exploration of its biological applications

The biosynthesis of silver nanoparticles (AgNPs) has been proved to be a cost effective and environmental friendly approach toward chemical and physical methods. In the present study, biosynthesis of AgNPs was carried out using aqueous extract of Zea mays (Zm) husk. The initial colour change from golden yellow to orange was observed between 410 and 450 nm which confirmed the synthesis of AgNPs. Also, dynamic light scattering‐particle size analysis confirmed the average size to be 113 nm and zeta potential value of −28 kV. The morphology of synthesised Zm AgNPs displayed flower‐shaped structure, X‐ray diffraction pattern revealed the strongest peaks at 2θ = 38.6° and 64° which proved that the nanoparticle has the face centred crystalline structure. The Fourier transform infrared spectroscopy results showed strong absorption bands at 1394.53, 2980.02 and 2980.02 cm⁻¹ due to the presence of alkynes, carboxylic acids, alcoholic and phenolic groups. The maximum zone of inhibition was observed against Salmonella typhi (22 mm) and Candida albicans (18 mm). The synthesised nanoparticles exhibited more free radical scavenging activity than the aqueous plant extract. This is the first report on the synthesis of AgNP from Zm husk, delivers the efficient and stable Zm AgNPs through simple feasible approach toward green biotechnology.Inspec keywords: silver, nanoparticles, nanofabrication, light scattering, particle size, X‐ray diffraction, crystal structure, Fourier transform infrared spectra, absorption coefficients, free radicalsOther keywords: green synthesis, silver nanoparticles, biosynthesis, environmental friendly approach, aqueous extract, Zea mays husk, colour change, golden yellow, dynamic light scattering‐particle size analysis, average size, zeta potential value, flower‐shaped structure, X‐ray diffraction pattern, face centred crystalline structure, Fourier transform infrared spectroscopy, absorption bands, alkynes, carboxylic acids, alcoholic groups, phenolic groups, Salmonella typhi, Candida albicans, free radical scavenging activity, aqueous plant extraction, green biotechnology, size 113 nm, wavelength 410 nm to 450 nm     

Improved bounds for large scale capacitated arc routing problem

The Capacitated Arc Routing Problem (CARP) stands among the hardest combinatorial problems to solve or to find high quality solutions. This becomes even more true when dealing with large instances. This paper investigates methods to improve on lower and upper bounds of instances on graphs with over 200 vertices and 300 edges, dimensions that, today, can be considered of large scale. On the lower bound side, we propose to explore the speed of a dual ascent heuristic to generate capacity cuts. These cuts are next improved with a new exact separation enchained to the linear program resolution that follows the dual heuristic. On the upper bound, we implement a modified Iterated Local Search procedure to Capacitated Vehicle Routing Problem (CVRP) instances obtained by applying a transformation from the CARP original instances. Computational experiments were carried out on the set of large instances generated by Brandão and Eglese and also on the regular size sets. The experiments on the latter allow for evaluating the quality of the proposed solution approaches, while those on the former present improved lower and upper bounds for all instances of the corresponding set.     

Biosynthesis of polyunsaturated fatty acids in the developing brain: II. Metabolic transformations of intracranially administered [3-14C] eicosatrienoic acid,evidence for lack of Δ8 desaturasedesaturase

[3-¹⁴C] Eicosatrienoic acid (Δ11,14,17) chemically synthesized from [1-¹⁴C] linolenic acid was injected intracranially into 14-day old rats and sacrificed 8 hr later. The analysis of brain fatty acids by radio-gas liquid chromatography before and after ozonolysis showed that the tetraene fraction consisted of a desaturated product, Δ5,11,17–20∶4, and its elongated product, Δ7,13,16,19–22∶4. Both of these products, with a combined total of 61% of the total radioactivity recovered in the tetraene fraction, contain a nonmethylene interrupted double bond system and, therefore, are unsuitable for further desaturation. The other two components, Δ6,9,12,15–18∶4 and Δ8,11,14,17–20∶4, must have been formed from Δ9,12,15–18∶3, formed by retroconversion of the starting material 20∶3, followed by desaturation and elongation. These results suggest a lack of Δ⁸ desaturase in the developing brain, leading to formation of Δ5,11,14,17–20∶4 rather than Δ8,11,14,17–20∶4. Howeve, the nonmethylene interrupted double bond isomer does not restrict chain elongation.