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71.
An ion-counting nanodosemeter (ND) yielding the distribution of radiation-induced ions in a low-pressure gas within a millimetric, wall-less sensitive volume (SV) was equipped with a silicon microstrip telescope that tracks the primary particles, allowing correlation of nanodosimetric data with particle position relative to the SV. The performance of this tracking ND was tested with a broad 250 MeV proton beam at Loma Linda University Medical Center. The high-resolution tracking capability made it possible to map the ion registration efficiency distribution within the SV, for which only calculated data were available before. It was shown that tracking information combined with nanodosimetric data can map the ionisation pattern of track segments within 150 nm-equivalent long SVs with a longitudinal resolution of approximately 5 tissue-equivalent nanometers. Data acquired in this work were compared with results of Monte Carlo track structure simulations. The good agreement between 'tracking nanodosimetry' data acquired with the new system and simulated data supports the application of ion-counting nanodosimetry in experimental track-structure studies.  相似文献   
72.
Visual inspection and sensory analysis are the only suitable ways to assess the quality of hazelnuts under routine conditions. To obtain a more objective parameter for the freshness, a fast and easy-to-use method was developed. It is based on the well-known test for the germination capacity of seeds where their vitality is determined by use of 2,3,5-triphenyltetrazolium chloride (TTC) which is reduced by flavo enzymes to 1,3,5-triphenylformazane, which appears red. For the determination, 100 hazelnut halves were embedded in TTC containing methyl cellulose gel on a glass plate and kept at 35 °C in the dark. After 6 h, the cut planes of viable nuts were stained red, the cut planes of rotten nuts were yellow or brown, and the colour of dead or mould-infected nuts remained unchanged. The colour pattern was examined either visually by counting the coloured halves or with computer support using image editing software. The ratio of the sum of coloured areas to the total area of the hazelnut cut planes gave a measure of the average degree of viability ("vitality index"). The analysis of several samples of hazelnuts of well-defined age and storage conditions confirmed the efficiency of the method.  相似文献   
73.
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Abstract State Machines (ASMs) allow modeling system behaviors at any desired level of abstraction, including a level with rich data types, such as sets, sequences, maps, and user-de.ned data types. The availability of high-level data types allow state elements to be represented both abstractly and faithfully at the same time. In this paper we look at symbolic analysis of ASMs. We consider ASMs over a .xed state background T that includes linear arithmetic, sets, tuples, and maps. For symbolic analysis, ASMs are translated into guarded update systems called model programs. We formulate the problem of bounded path exploration of model programs, or the problem of Bounded Model Program Checking (BMPC) as a satis.ability problem modulo T . Then we investigate the boundaries of decidable and undecidable cases for BMPC. In a general setting, BMPC is shown to be highly undecidable (Σ11-complete); and even when restricting to .nite sets the problem remains re-hard (Σ01-hard). On the other hand, BMPC is shown to be decidable for a class of basic model programs that are common in practice. We use Satis.ability Modulo Theories (SMT) for solving BMPC; an instance of the BMPC problem is mapped to a formula, the formula is satis.able modulo T if and only if the corresponding BMPC problem instance has a solution. The recent SMT advances allow us to directly analyze speci.cations using sets and maps with specialized decision procedures for expressive fragments of these theories. Our approach is extensible; background theories need in fact only be partially solved by the SMT solver; we use simulation of ASMs to support additional theories that are beyond the scope of available decision procedures.  相似文献   
74.
BACKGROUND: Previous studies have shown that the trochlear notch is deeper than necessary for an exact fit with the humerus. However, humero-ulnar joint space width and contact areas have so far not been quantified for variations in the load and angle of flexion. METHODS: Six fresh cadaveric specimens were investigated at 30 degrees, 60 degrees, 90 degrees, and 120 degrees of flexion and at loads of 25 and 500 N, simulating resisted elbow extension. The joint space width and contact were determined, using polyether casting material. RESULTS: At 25 N all joints made contact in the ventral and dorsal aspects of the articular surfaces, whereas in the depth of the trochlear notch the joint space was on average between 0.3 and 2.8 mm wide, with some variation between individuals. At 500 N the joint space width was considerably reduced and the contract areas expanded towards the depth of the notch. The size of the dorsal contact areas was significantly smaller at 30 degrees and that of the ventral ones at 120 degrees, their ventro-dorsal ratio decreasing considerably from 30 degrees to 120 degrees (p < 0.01). CONCLUSION: These results indicate that the size of the contact areas depends to a slight extent on the joint position, but that at all loads and flexion angles a bicentric contact and an important central joint space width emerge because of the concave incongruity of the joint. These data may be used for numerical calculations, analysing the effects of incongruity on the joint stress and on the functional adaptation of the subarticular tissues.  相似文献   
75.
Presents a model of consultation based on A. Bandura's (1977) social learning theory. The philosophical assumptions of the model, which are drawn from reciprocal determinism, are presented, as are the roles and principles that govern this model. The consulting process, which involves relationship building, assessment, problem statement, goal setting, intervention, and evaluation, is also described. Implications of the model for consultants are discussed, an illustrative case vignette is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
76.
The change in hydrogen concentration as a function of applied strain has been studied in commercial titanium alloys that included threeβ-phase, twoα-phase, and an (α + β)-phase Ti-6Al-4V alloy with differingα/β morphologies.Insitu measurements were made using a nondestructive nuclear technique on samples for which uniaxial compressive and tensile stresses were applied by four-point bending. Theβ-phase alloys exhibited hydrogen redistribution under an elastic stress gradient, but no further change was discernible accompanying plastic deformation. The extent of hydrogen concentration change for theβ-phase alloys was of the order of 4 to 6 pct for a 620 MPa stress gradient. This is less than would be predicted based on available data for the partial molal volume of hydrogen. Diffusion coefficients in a stress gradient were also determined and are consistent with those measured inβ-phase titanium at elevated and room temperatures. Within the experimental sensitivities there was no evidence of hydrogen redistribution with applied stress for theα-phase and Ti-6Al-4V alloys.  相似文献   
77.
Several high-temperature processes in chemical,petrochemical, and energy-processing industry arecharacterized by H2S-containing atmospheres,confronting engineers with severe corrosion attack ofthe metallic components. Sulfidation is observed onmaterials used for heat exchangers within theheat-recovery zones. The damage is originated not onlyby the relatively fast growth rates of the sulfidescales, but is also due to the loss of their limitedprotective effect by cracking. Scale failure, as aconsequence of stresses generated during scale growthand by temperature changes, was investigated on a carbon steel, a low-chromium steel (1Cr-0.4Mo, T12),a ferritic-chromium steel (12Cr-1Mo), and on austeniticsteel (18Cr-9Ni, AISI 321). The experiments in thetemperature range 400-600°C (700°C), withsubsequent cooling to ambient temperature, wereaccompanied by acoustic-emission measurements in orderto detect scale cracking. Critical parameters for scalefailure are presented.  相似文献   
78.
    
Natural fiber-reinforced composites (NFRCs) suffer from water absorption and low temperature stability, resulting in fiber degradation and subsequent material failure. Built-in piezoresistive sensors are investigated to monitor the deformation/strain of the component. As a low-cost material from renewable resources biochar particles derived from olive stones were applied on flax plies and yarn bundles that served as model systems. Carbon black samples as petrochemical variants were used as a reference material. Biochar and carbon black-covered fiber systems were laminated in epoxy resin followed by tensile tests. The electrical resistance was recorded simultaneously during testing. Biochar with a broad size distribution from nano to high micrometer range (D < 200 μm) was superior in sensor performance compared to carbon black and biochar with a smaller particle size range D < 20 μm. Gauge factors (GF) of NFRC samples with integrated biochar particles reached 30–80 while carbon black could not exceed a GF of 8. To obtain maximum GFs, yarn count of flax yarn/ply substrate should be as thin as possible, but still enable percolation of the adhering particle network. Comparatively large particle size was identified as a contributing factor enabling the high GF for coarse biochar compared to carbon black.  相似文献   
79.
    
Connexins (Cx) form gap junctions (GJ) and allow for intercellular communication. However, these proteins also modulate gene expression, growth, and cell migration. The downregulation of Cx43 impairs endothelial cell migration and angiogenetic potential. Conversely, endothelial Cx43 expression is upregulated in an in vivo angiogenesis model relying on hemodynamic forces. We studied the effects of Cx43 expression on tube formation and proliferation in HUVECs and examined its dependency on GJ communication. Expectedly, intercellular communication assessed by dye transfer was linked to Cx43 expression levels in HUVECs and was sensitive to a GJ blockade by the Cx43 mimetic peptide Gap27. The proliferation of HUVECs was not affected by Cx43 overexpression using Cx43 cDNA transfection, siRNA-mediated knockdown of Cx43, or the inhibition of GJ compared to the controls (transfection of an empty vector, scrambled siRNA, and the solvent). In contrast, endothelial tube and sprout formation in HUVECs was minimized after Cx43 knockdown and significantly enhanced after Cx43 overexpression. This was not affected by a GJ blockade (Gap27). We conclude that Cx43 expression positively modulates the angiogenic potential of endothelial cells independent of GJ communication. Since proliferation remained unaffected, we suggest that Cx43 protein may modulate endothelial cell migration, thereby supporting angiogenesis. The modulation of Cx43 expression may represent an exploitable principle for angiogenesis induction in clinical therapy.  相似文献   
80.
    
This review of the literature on varietal change in sub-Saharan Africa looks in detail at adoption of new varieties of bananas in Uganda, cassava in Nigeria, potato in Kenya, sweetpotato in Uganda and yams in Côte d’Ivoire. The review explored three hypotheses about drivers of varietal change. There was a strong confirmation for the hypothesis that insufficient priority given to consumer-preferred traits by breeding programmes contributes to the limited uptake of modern varieties (MVs) and low varietal turnover. Lack of evidence meant the second hypothesis of insufficient attention to understanding and responding to gender differences in consumer preferences for quality and post-harvest traits was unresolved. The evidence on the third hypothesis about the informal seed system contributing to slow uptake of MVs was mixed. In some cases, the informal system has contributed to rapid uptake of MVs, but often it appears to be a barrier with inconsistent varietal naming a major challenge.  相似文献   
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