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41.
We undertake a systematic study of the role of neural architecture in shaping the dynamics of evolved model pattern generators for a walking task. First, we consider the minimum number of connections necessary to achieve high performance on this task. Next, we identify architectural motifs associated with high fitness. We then examine how high-fitness architectures differ in their ability to evolve. Finally, we demonstrate the existence of distinct parameter subgroups in some architectures and show that these subgroups are characterized by differences in neuron excitabilities and connection signs. 相似文献
42.
Sediment contribution of specific areas of a watershed is an important consideration, but one that is often overlooked, when developing watershed management plans. Understanding sediment delivery to the watershed outlet is one method for identifying high contribution areas. In this study, a new methodology for calculating individual subbasin sediment delivery ratio (SDR) was developed within the Soil and Water Assessment Tool (SWAT) for two Michigan watersheds. Subbasins with the greatest SDR had two defining characteristics: high erosion rates and close proximity to the watershed outlet. The impact of best management practice (BMP) implementation (no-tillage and Conservation Reserve Program) on sediment yield reduction at the watershed outlet was compared for two targeting methods (SDR and erosion rate). Identifying SDR of individual subbasins for implementation of BMPs is more effective method for addressing water quality concerns at the watershed outlet than the widely used targeting high risk erosion areas. Watershed SDR was found to be highly variable on a monthly basis, due to changes in sediment yield, which is in turn affected by factors such as precipitation and surface runoff. Finally, watershed SDR calculated using the physically-based SWAT model was compared to four empirically-based areal relationships with SDR. While some area methods reproduced the SWAT-SDR, the variations between areal methods indicate that more detailed physical characteristics should be considered in watershed SDR calculation. 相似文献
43.
O'Brien S Luo Y Wu C Petrak M Bohm E Brandt JM 《Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine》2012,226(3):235-245
The micromotion at the interface between the polyethylene tibial insert and metal tibial tray [corrected] in modular total knee replacements [corrected] has been shown to contribute to wear particle-induced osteolysis and may [corrected] cause implant failure. Therefore, studying the design parameters that are involved in the backside wear process is an important task that may lead to improvement in new total knee replacements. In the present study, a finite element model was developed to predict the backside micromotion along the entire modular interface. Both the linear elastic constitutive model and non-linear J2-plasticity constitutive model were considered in the finite element model for polyethylene and were corroborated against published results obtained from displacement controlled knee simulator wear tests. The finite element simulation with the non-linear J2-plasticity constitutive model was able to predict backside micromotion [corrected] more accurately than the simulation with the linear elastic constitutive model. [corrected] The developed finite element model (including the non-linear J2-plasticity constitutive model) was then applied to assess the effects of the tibial tray locking mechanism design (dovetails versus fullperipheral [corrected] design) and different levels of interference fit on insert micromotion. The developed finite element model, implementing the non-linear J2-plasticity constitutive model, was shown to successfully predict clinical amounts of backside micromotion and could be used for the design and development of total knee replacements for the reduction of backside micromotion and polyethylene [corrected] wear. 相似文献
44.
Hyunkyu Lee Pauline L. Baniqued Joshua Cosman Sean Mullen Edward McAuley Joan Severson Arthur F. Kramer 《Computers in human behavior》2012
Many studies conducted in a laboratory or university setting are limited by funding, personnel, space, and time constraints. In the present study, we introduce a method of data collection using a mobile application that circumvents these typical experiment administration issues. Using the application, we examined cross-sectional age differences in cognitive function. We obtained data from more than 15,000 participants and replicated specific patterns of age-related differences in cognition. Using a subset of these participants, we also examined the processing speed account of age-related cognitive differences, and the association of exercise and leisure activity with cognitive function across the lifespan. We discuss the relative advantages and disadvantages of data collection with a mobile application, and provide recommendations for the use of this method in research. 相似文献
45.
46.
James Lockerbie Neil Arthur McDougall Maiden Jorgen Engmann Debbie Randall Sean Jones David Bush 《Requirements Engineering》2012,17(3):227-254
This paper describes the application of requirements engineering concepts to support the analysis of the impact of new software systems on system-wide goals. Requirements on a new or revised software component of a socio-technical system not only have implications on the goals of the subsystem itself, but they also impact upon the goals of the existing integrated system. In industries such as air traffic management and healthcare, impacts need to be identified and demonstrated in order to assess concerns such as risk, safety, and accuracy. A method called PiLGRIM was developed which integrates means-end relationships within goal modelling with knowledge associated with the application domain. The relationship between domain knowledge and requirements, as described in a satisfaction argument, adds traceability rationale to help determine the impacts of new requirements across a network of heterogeneous actors. We report procedures that human analysts follow to use the concepts of satisfaction arguments in a software tool for i* goal modelling. Results were demonstrated using models and arguments developed in two case studies, each featuring a distinct socio-technical system??a new controlled airspace infringement detection tool for NATS (the UK??s air navigation service provider), and a new version of the UK??s HIV/AIDS patient reporting system. Results provided evidence towards our claims that the conceptual integration of i* and satisfaction arguments is usable and useful to human analysts, and that the PiLGRIM impact analysis procedures and tool support are effective and scalable to model and analyse large and complex socio-technical systems. 相似文献
47.
Sean J. Barbeau Miguel A. Labrador Philip L. Winters Rafael Perez Nevine Labib Georggi 《Communications Magazine, IEEE》2006,44(11):156-163
The widespread use of cellular telephones and the availability of user-location information are facilitating the development of new personalized, location-based applications. However, as of today, most of these applications are unidirectional and text-based where the user subscribes and the system sends a text message when appropriate. This article describes a modular and general architecture that supports the development of interactive, multimedia, location-based applications, providing an extra level of service to the users. The flexibility of the architecture is demonstrated by presenting the wireless safety security system (Wi-Via) and other potential applications 相似文献
48.
Sean MacDonald 《华东电力》2003,32(11):73-76
联合循环机组日益广泛应用于发电厂。与传统的燃煤机组相比 ,联合发电厂的设备及安装成本、发电效率高 ,而且对环境影响小。余热锅炉 ( HRSG)是联合循环机组的一个组成部分。虽然 HRSG的热负荷比传统锅炉低 [1] ,但锅炉水化学却很重要。因此 ,新建 HRSG的化学清洗一直受到关注。传统的新建锅炉中存在油脂 ,氧化皮及焊渣等 ,其化学清洗是为了除去这类杂质以保障机组的正常启动及运行。HRSG系统中存在类似的杂质 ,但 HRSG由两到三个压力不同的蒸汽发生回路所组成 (见图 1 ) ,化学清洗较为复杂。这种锅炉结构一般需要多步或扩大性化学… 相似文献
49.
Steptoe Andrew; Perkins-Porras Linda; Rink Elisabeth; Hilton Sean; Cappuccio Francesco P. 《Canadian Metallurgical Quarterly》2004,23(6):574
This study assessed psychological and social factors predicting 12-month changes in fruit and vegetable consumption achieved by 271 men and women from a low-income population randomized to brief behavioral and nutrition education counseling. Greater increases in fruit and vegetable intake were achieved in the behavioral than in the nutrition education condition (1.49 vs. 0.87 portions per day, p=.021). Increases were predicted by baseline social support for dietary change but not by baseline psychological measures. However, short-term (8-week) changes in dietary self-efficacy, encouragement, anticipated regret, perceived benefits, and knowledge of recommended intake predicted 12-month changes in fruit and vegetable consumption independently of gender, age, ethnicity, income, and baseline intake. These factors accounted for 51% of the superiority of behavioral counseling over nutrition education. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
50.
Dr. Vladimir O. Talibov Dr. Edoardo Fabini Edward A. FitzGerald Dr. Daniele Tedesco Daniela Cederfeldt Martin J. Talu Moira M. Rachman Filip Mihalic Dr. Elisabetta Manoni Dr. Marina Naldi Dr. Paola Sanese Dr. Giovanna Forte Dr. Martina Lepore Signorile Prof. Xavier Barril Dr. Cristiano Simone Prof. Manuela Bartolini Dr. Doreen Dobritzsch Dr. Alberto Del Rio Prof. U. Helena Danielson 《Chembiochem : a European journal of chemical biology》2021,22(9):1597-1608
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 were determined (KD=42 and 84 μM, respectively). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although SMYD3–HSP90 binding was confirmed (KD=13 μM). Diperodon clearly represents a novel starting point for the design of tool compounds interacting with a druggable allosteric site, suitable for the exploration of noncatalytic SMYD3 functions and therapeutics with new mechanisms of action. 相似文献