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排序方式: 共有237条查询结果,搜索用时 15 毫秒
21.
Daria Kartasheva-Ebertz Jesintha Gaston Loriane Lair-Mehiri Estelle Mottez Tan-Phuc Buivan Pierre-Philippe Massault Olivier Scatton Sebastien Gaujoux Jean-Christophe Vaillant Stanislas Pol Sylvie Lagaye 《International journal of molecular sciences》2022,23(17)
IL-17A is considered to guide liver inflammation and fibrosis. From twenty-two human liver samples of different fibrosis stages (F0 to F4), IL-17A, IL-22, and TGFβ1 protein expression in liver tissue lysates were analyzed. Ten paired samples of liver tissue (F0–F1 stage) and blood from the same patient were used to analyze intrahepatic and blood T-lymphoid IL-17A+ cells by flow cytometry. The analyses have been performed regardless of pathology, considering the stage of fibrosis. Human liver tissue was used for the primary human liver slice cultures, followed by subsequent cytokine stimulation and fibrotic markers’ analysis by ELISA. IL-17A production in human liver tissue was significantly higher in the early fibrotic stage compared with the advanced stage. Th17 T cells and, to a lesser extent, MAIT cells were the main sources of IL-17A in both compartments, the liver and the blood. Moreover, the presence of liver Th17IL-17A+INFγ+ cells was detected in the liver. IL-17A stimulation of human liver slice culture increased the expression of profibrotic and pro-inflammatory markers. IL-17A, secreted by Th17 and MAIT cells in the liver, triggered fibrosis by inducing the expression of IL-6 and profibrotic markers and could be a target for antifibrotic treatment. Further amplitude studies are needed to confirm the current results. 相似文献
22.
Stephan Schöttl Richard Rusby Henri Godfrin Matthias Meschke Valérie Goudon Sebastien Triqueneaux Andrea Peruzzi Martin J. de Groot Reyer Jochemsen Wim Bosch Yves Hermier Laurent Pitre Céline Rives Bernd Fellmuth Jost Engert 《Journal of Low Temperature Physics》2005,138(3-4):941-946
No Heading Recently, a superconductive reference device, SRD1000, with ten reference materials has been developed to enable simplified in situ calibration of interpolating thermometers. We report on the evaluation of SRD1000 prototypes at various laboratories. The devices were built and tested by HDL and KOL, calibrated at NMi-VSL and then distributed to other partners where they were re-calibrated against the local realisations of the PLTS-2000 or laboratory scales. As a result, we obtained data on the superconductive transition temperatures, widths and shapes for four different devices. Reproducibility, sharpness of the transitions, supercooling and sensitivity to magnetic fields are evaluated. This leads to estimates of the uncertainty in determination of the transition midpoint and temperature.PACS numbers: 07.20.Dt, 07.20.Mc, 74.62.–c, 74.70.Ad 相似文献
23.
Céline Moulin Alain Glière Daniel Barbier Sebastien Joucla Blaise Yvert Pascal Mailley Régis Guillemaud 《IEEE transactions on bio-medical engineering》2008,55(2):683-692
A transient finite-element model has been developed to simulate an extracellular action potential recording in a tissue slice by a planar microelectrode array. The thin-film approximation of the active neuron membrane allows the simulation within single finite-element software of the intracellular and extracellular potential fields. In comparison with a compartmental neuron model, it is shown that the thin-film approximation-based model is able to properly represent the neuron bioelectrical behavior in terms of transmembrane current and potential. Moreover, the model is able to simulate extracellular action potential recordings with properties similar to those observed in biological experiments. It is demonstrated that an ideal measurement system model can be used to represent the recording microelectrode, provided that the electronic recording system adapts to the electrode-tissue interface impedance. By comparing it with a point source approximated neuron, it is also shown that the neuron three-dimensional volume should be taken into account to simulate the extracellular action potential recording. Finally, the influence of the electrode size on the signal amplitude is evaluated. This parameter, together with the microelectrode noise, should be taken into account in order to optimize future microelectrode designs in terms of the signal-to-noise ratio. 相似文献
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25.
Bachelot R Lerondel G Blaize S Aubert S Bruyant A Royer P 《Microscopy research and technique》2004,64(5-6):441-452
This report presents the Apertureless Scanning Optical Near-Field Microscope as a powerful tool for the characterization of modern optoelectronic and photonic components with sub-wavelength resolution. We present an overview of the results we obtained in our laboratory over the past few years. By significant examples, it is shown that this specific probe microscopy allows for in situ local quantitative study of semiconductor lasers in operation, integrated optical waveguides produced by ion exchange (single channel or Y junction), and photonic structures. 相似文献
26.
Ryan L. Truby Michael Wehner Abigail K. Grosskopf Daniel M. Vogt Sebastien G. M. Uzel Robert J. Wood Jennifer A. Lewis 《Advanced materials (Deerfield Beach, Fla.)》2018,30(15)
Humans possess manual dexterity, motor skills, and other physical abilities that rely on feedback provided by the somatosensory system. Herein, a method is reported for creating soft somatosensitive actuators (SSAs) via embedded 3D printing, which are innervated with multiple conductive features that simultaneously enable haptic, proprioceptive, and thermoceptive sensing. This novel manufacturing approach enables the seamless integration of multiple ionically conductive and fluidic features within elastomeric matrices to produce SSAs with the desired bioinspired sensing and actuation capabilities. Each printed sensor is composed of an ionically conductive gel that exhibits both long‐term stability and hysteresis‐free performance. As an exemplar, multiple SSAs are combined into a soft robotic gripper that provides proprioceptive and haptic feedback via embedded curvature, inflation, and contact sensors, including deep and fine touch contact sensors. The multimaterial manufacturing platform enables complex sensing motifs to be easily integrated into soft actuating systems, which is a necessary step toward closed‐loop feedback control of soft robots, machines, and haptic devices. 相似文献
27.
Charles Guillemard Wei Zhang Gregory Malinowski Claudia de Melo Jon Gorchon Sebastien Petit-Watelot Jaafar Ghanbaja Stéphane Mangin Patrick Le Fèvre Francois Bertran Stéphane Andrieu 《Advanced materials (Deerfield Beach, Fla.)》2020,32(26):1908357
Engineering of magnetic materials for developing better spintronic applications relies on the control of two key parameters: the spin polarization and the Gilbert damping, responsible for the spin angular momentum dissipation. Both of them are expected to affect the ultrafast magnetization dynamics occurring on the femtosecond timescale. Here, engineered Co2MnAlxSi1-x Heusler compounds are used to adjust the degree of spin polarization at the Fermi energy, P, from 60% to 100% and to investigate how they correlate with the damping. It is experimentally demonstrated that the damping decreases when increasing the spin polarization from 1.1 × 10−3 for Co2MnAl with 63% spin polarization to an ultralow value of 4.6 × 10−4 for the half-metallic ferromagnet Co2MnSi. This allows the investigation of the relation between these two parameters and the ultrafast demagnetization time characterizing the loss of magnetization occurring after femtosecond laser pulse excitation. The demagnetization time is observed to be inversely proportional to 1 – P and, as a consequence, to the magnetic damping, which can be attributed to the similarity of the spin angular momentum dissipation processes responsible for these two effects. Altogether, the high-quality Heusler compounds allow control over the band structure and therefore the channel for spin angular momentum dissipation. 相似文献
28.
Multibody System Dynamics - Sensitivity analysis computes the derivatives of general cost functions that depend on the system solution with respect to parameters or initial conditions. This work... 相似文献
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30.
Pirard Thomas Kitsikoudis Vasileios Erpicum Sebastien Pirotton Michel Archambeau Pierre Dewals Benjamin 《Water Resources Management》2022,36(4):1237-1250
Water Resources Management - Water distribution networks often exhibit excess pressure that could lead to extensive leakage and infrastructure damages. While this problem can be mitigated with... 相似文献