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In this study, isobutyl acetate, a valuable solvent in cosmetics, aroma and paint industries, is produced by pervaporation–esterification equilibrium reaction in a batch pervaporation membrane reactor (PVMR) using homogeneous (sulphuric acid) and heterogeneous (Dowex 50W-X8) catalysts. The effects of catalyst loading, catalyst type, reaction time, membrane thickness, temperature and initial molar ratio of reactants were investigated. A cross-linked polydimethylsiloxane (PDMS) membrane selective to esters was prepared and used in PVMR. Batch reactions were carried out also in a simple batch reactor (SBR) without pervaporation under the same conditions to compare the conversions for the reactions with and without pervaporation. In conclusion, PVMR experiments showed that the PDMS membrane can be used to remove the isobutyl acetate formed selectively with acceptable conversions and pervaporation fluxes.  相似文献   
64.
The removal of two anionic dyes, C.I. Acid Orange 7 (AO7) and C.I. Acid Red 17 (AR17), by ultrasound-assisted adsorption on the modified nanoclay in aqueous solutions was studied. The modified nanoclay was characterized by SEM/EDX, BET, XRD and FT-IR techniques. The average crystal size for the interlayer spacing of the modified nanoclay was about 14.3 nm. Central composite design (CCD) was used for the optimization of the operational parameters, including the initial dye concentration, sonication time, adsorbent dosage and temperature. The results demonstrated a good agreement between the predicted values obtained by the model and the experimental values for both AO7 (R2= 0.959) and AR17 (R2=0.971).  相似文献   
65.
Lot sizing problems are production planning problems with the objective of determining the periods where production should take place and the quantities to be produced in order to satisfy demand while minimizing production, setup and inventory costs. Most lot sizing problems are combinatorial and hard to solve. In recent years, to deal with the complexity and find optimal or near-optimal results in reasonable computational time, a growing number of researchers have employed meta-heuristic approaches to lot sizing problems. One of the most popular meta-heuristics is genetic algorithms which have been applied to different optimization problems with good results. The focus of this paper is on the recent published literature employing genetic algorithms to solve lot sizing problems. The aim of the review is twofold. First it provides an overview of recent advances in the field in order to highlight the many ways GAs can be applied to various lot sizing models. Second, it presents ideas for future research by identifying gaps in the current literature. In reviewing the relevant literature the focus has been on the main features of the lot sizing problems and the specifications of genetic algorithms suggested in solving these problems.  相似文献   
66.
The buffer allocation problem is an NP-hard combinatorial optimization problem and it is an important research issue in designing manufacturing systems. The problem deals with finding optimal buffer sizes to be allocated into buffer areas in a production system to achieve a specific objective. This paper presents a comprehensive survey on buffer allocation problem in production systems. To provide a systematic review of current relevant research, first studies are grouped in two categories: 1. Reliable production lines, 2. Unreliable production lines. Next, the studies in each group are reviewed based on topology of the production line, the solution methodologies suggested and the objective function employed. The aim of this review is twofold. First, it provides an overview of recent advances in the field in order to highlight the new trends in solution methodology. Second, it presents ideas for future research by identifying gaps in the current literature.  相似文献   
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Activated carbon was used as an adsorbent for the removal of phenol from aqueous solution under various operating conditions. Statistical design using MATLAB® tools was employed to study the effects of three variables on six different response factors. MATLAB® software was employed to solve proposed quadratic model equations and for fitting a quadratic response surface. All the models with a very high adjusted R‐square predicted the experimental data well. The Thomas, the Yoon‐Nelson, the Wolborska, the bed depth service time, and the linear driving force models were used to predict breakthrough curves for experimental data. The results showed that the linear driving force model was suitable for the prediction of the breakthrough curve data.  相似文献   
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Abstract

In this study, mechanically deboned chicken meat residues were hydrolyzed by protease enzyme and chicken meat hydrolyzate was freeze-dried in order to produce high-quality meat powder. Due to its high cost, energy and time consumption, freeze-drying conditions needed to be optimized. Response surface methodology was used for optimization with the independent variables shelf temperature, lyophilization temperature and freezing rate. The responses were sublimation time, solubility and in vitro protein digestibility. The optimum conditions were shelf temperature, 15?°C; lyophilization temperature, –10?°C; and freezing rate, 2.0?°C/min. Sublimation time, solubility and in vitro protein digestibility for this optimum conditions were found to be 590.344?min, 25.626% and 23.808%, respectively.  相似文献   
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We present a Turkish family with two cousins (OC15 and OC15b) affected with syndromic developmental delay, microcephaly, and trigonocephaly but with some phenotypic traits distinct between them. OC15 showed asymmetrical skeletal defects and syndactyly, while OC15b presented with a more severe microcephaly and semilobal holoprosencephaly. All four progenitors were related and OC15 parents were consanguineous. Whole Exome Sequencing (WES) analysis was performed on patient OC15 as a singleton and on the OC15b trio. Selected variants were validated by Sanger sequencing. We did not identify any shared variant that could be associated with the disease. Instead, each patient presented a de novo heterozygous variant in a different gene. OC15 carried a nonsense mutation (p.Arg95*) in PORCN, which is a gene responsible for Goltz-Gorlin syndrome, while OC15b carried an indel mutation in ZIC2 leading to the substitution of three residues by a proline (p.His404_Ser406delinsPro). Autosomal dominant mutations in ZIC2 have been associated with holoprosencephaly 5. Both variants are absent in the general population and are predicted to be pathogenic. These two de novo heterozygous variants identified in the two patients seem to explain the major phenotypic alterations of each particular case, instead of a homozygous variant that would be expected by the underlying consanguinity.  相似文献   
70.
In general, the maintenance and spare parts inventory policies are treated either separately or sequentially in industry. However, since the stock level of spare parts is often dependent on the maintenance policies, it is a better practice to deal with these problems simultaneously. In this study, a simulation optimization approach using genetic algorithms (GAs) has been proposed for the joint optimization of preventive maintenance (PM) and spare provisioning policies of a manufacturing system operating in the automotive sector. A factorial experiment was carried out to identify the best values for the GA parameters, including the probabilities of crossover and mutation, the population size, and the number of generations. The computational experiments showed that the parameter settings given by the proposed approach achieves a significant cost reduction while increasing the throughput of the manufacturing system.  相似文献   
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