FIB与PEM联用在半导体器件失效分析中的应用

在半导体器件的失效分析中,缺陷定位是必不可少的重要环节.光发射显微镜(PEM)是IC失效定位中最有效的工具之一.PEM利用了IC器件缺陷在一定条件下的发光现象,迅速定位缺陷.而聚焦等离子束(FIB)的定点切割和沉积技术在亚微米级半导体工艺失效分析中扮演着越来越重要的作用.介绍了一种联合使用FIB和PEM进行亚微米级缺陷定位的新方法,使得一些单独使用PEM无法完成缺陷定位的案例得以成功解决.     

Health and wellness monitoring through wearable and ambient sensors: exemplars from home-based care of elderly with mild dementia

Monitoring and timely intervention are extremely important in the continuous management of health and wellness among all segments of the population, but particularly among those with mild dementia. In relation to this, we prescribe three design principles for the construction of services and applications. These are ambient intelligence, service continuity, and micro-context. In this paper, we provide three exemplars from our research and development activities that illustrate the use of these design principles in the construction of services and applications. All the applications are drawn from the field of care for mild dementia patients in their living quarters.     

Loss performance of tagged and normal ATM cells at a partiallyshared buffer

The loss performance of tagged and normal ATM cells at a first-in-first-out (FIFO) buffer is studied. The authors show that if a partial buffer sharing mechanism is adopted the loss probability of normal cells can be firmly guaranteed, regardless of the traffic intensity of tagged cells     

Lateral dimerization is required for the homophilic binding activity of C-cadherin

Regulation of cadherin-mediated adhesion can occur rapidly at the cell surface. To understand the mechanism underlying cadherin regulation, it is essential to elucidate the homophilic binding mechanism that underlies all cadherin-mediated functions. Therefore, we have investigated the structural and functional properties of the extracellular segment of Xenopus C-cadherin using a purified, recombinant protein (CEC 1-5). CEC 1-5 supported adhesion of CHO cells expressing C-cadherin. The extracellular segment was also capable of mediating aggregation of microspheres. Chemical cross-linking and gel filtration revealed that CEC 1-5 formed dimers in the presence as well as absence of calcium. Analysis of the functional activity of purified dimers and monomers demonstrated that dimers retained substantially greater homophilic binding activity than monomers. These results demonstrate that lateral dimerization is necessary for homophilic binding between cadherin extracellular segments and suggest multiple potential mechanisms for the regulation of cadherin activity. Since the extracellular segment alone possessed significant homophilic binding activity, the adhesive activity of the extracellular segment in a cellular context was analyzed. The adhesion of CHO cells expressing a truncated version of C-cadherin lacking the cytoplasmic tail was compared to cells expressing the wild-type C-cadherin using a laminar flow assay on substrates coated with CEC 1-5. CHO cells expressing the truncated C-cadherin were able to attach to CEC 1-5 and to resist detachment by low shear forces, demonstrating that tailless C-cadherin can mediate basic, weak adhesion of CHO cells. However, cells expressing the truncated C-cadherin did not exhibit the complete adhesive activity of cells expressing wild-type C-cadherin. Cells expressing wild-type C-cadherin remained attached to CEC 1-5 at high shear forces, while cells expressing the tailless C-cadherin did not adhere well at high shear forces. These results suggest that there may be two states of cadherin-mediated adhesion. The first, relatively weak state can be mediated through interactions between the extracellular segments alone. The second strong adhesive state is critically dependent on the cytoplasmic tail.     

Effects of healthy aging and early stage dementia of the Alzheimer's type on components of response time distributions in three attention tasks.

Objective: The characteristics of response time (RT) distributions beyond measures of central tendency were explored in 3 attention tasks across groups of young adults, healthy older adults, and individuals with very mild dementia of the Alzheimer's type (DAT). Method: Participants were administered computerized Stroop, Simon, and switching tasks, along with psychometric tasks that tap various cognitive abilities and a standard personality inventory (NEO-FFI). Ex-Gaussian (and Vincentile) analyses were used to capture the characteristics of the RT distributions for each participant across the 3 tasks, which afforded 3 components: μ and σ (mean and standard deviation of the modal portion of the distribution) and τ (the positive tail of the distribution). Results: The results indicated that across all 3 attention tasks, healthy aging produced large changes in the central tendency μ parameter of the distribution along with some change in σ and τ (mean ηp2 = .17, .08, and .04, respectively). In contrast, early stage DAT primarily produced an increase in the τ component (mean ηp2 = .06). τ was also correlated with the psychometric measures of episodic/semantic memory, working memory, and processing speed, and with the personality traits of neuroticism and conscientiousness. Structural equation modeling indicated a unique relation between a latent τ construct (–.90), as opposed to σ (–.09) and μ constructs (.24), with working memory measures. Conclusions: The results suggest a critical role of attentional control systems in discriminating healthy aging from early stage DAT and the utility of RT distribution analyses to better specify the nature of such change. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clinical pharmacology of bruceantin by radioimmunoassay

During the phase I clinical trial of a new antitumor agent, bruceantin, the pharmacology was studied in 18 cancer patients. The drug was infused intravenously (IV) for 3 h at doses ranging from 1 to 3.6 mg/m2 per day for 5 days. The plasma drug disappearance curves were biphasic, with a fast initial half-life of less than 15 min. The second half-life (t1/2 beta) varied from 0.7 to 38 h among different patients and was not dose-related. The difference between the t1/2 beta on day 1 and that on day 5 was not significant. In patients with normal liver function, the mean plasma concentration at the end of infusion was 22 ng/ml, and the value of the area under the concentration X time curve (AUC) was 111 (ng/ml)h. In contrast, in patients with abnormal liver function the corresponding values were 115 ng/ml and 830 (ng/ml)h, respectively. In addition, these patients had a slower elimination half-life of 10.9 h and a decreased total clearance of 157 ml/min/m2, as compared with 2.6 h and 671 ml/min/m2, respectively, for the normal group. All these differences were statistically significant. Patients with abnormal liver function developed more severe toxicity, including fever, severe nausea, vomiting, and hypotension. Two patients with severe hepatic dysfunction received a reduced dose and developed no toxicity. These results demonstrated the importance of the effects of liver dysfunction on drug disposition and showed that the dosage should be reduced in patients with hepatic dysfunction.     

Evaluation of the efficacy of sequential intravenous-oral administration of pefloxacin in community-acquired lower respiratory tract infections in patients with underlying conditions

We studied the efficacy of sequential intravenous-oral pefloxacin therapy in community-acquired lower respiratory tract infection in 24 patients with one or more underlying conditions. Twenty-eight patients were enrolled into the study but only 24 patients were evaluated. There were 16 males and 8 females with a mean age of 66.9 +/- 11.2 years (mean +/- SD, range 46 to 87 years). The underlying conditions present were bronchiectasis, chronic obstructive lung disease and diabetes mellitus. Patients who were older than 70 years but without any underlying condition were also enrolled. All received 4 days of intravenous pefloxacin 400 mg twice a day followed by oral pefloxacin 400 mg twice a day for another 10 days. Assessment of success was based on clinical, microbiological and radiological improvement. Pefloxacin produced 79.2% clinical cure rate. Another 8.3% showed improvement. Pefloxacin was well tolerated. There were few adverse effects and none of the patients required a change of antibiotic. Pefloxacin was an effective and well tolerated treatment for respiratory tract infection and had the advantage of broad in-vitro antibacterial activity, twice daily dosing and sequential availability in an intravenous and oral formulation.     

Context-aware mobile image annotation for media search and sharing

In recent years, rapid advances in media technology including acquisition, processing and distribution have led to proliferation of many mobile applications. Amongst them, one of the emerging applications is mobile-based image annotation that uses camera phones to capture images with system-suggested tags before uploading them to the media sharing portals. This procedure can offer information to mobile users and also facilitate the retrieval and sharing of the image for Web users. However, context information that can be acquired from mobile devices is underutilized in many existing mobile image annotation systems. In this paper, we propose a new mobile image annotation system that utilizes content analysis, context analysis and their integration to annotate images acquired from mobile devices. Specifically, three types of context, location, user interaction and Web, are considered in the tagging processes. An image dataset of Nanyang Technological University (NTU) campus has been constructed, and a prototype mobile image tag suggestion system has been developed. The experimental results show that the proposed system performs well in both effectiveness and efficiency on NTU dataset, and shows good potential in domain-specific mobile image annotation for image sharing.     

Deuteron Beam Source Based on Mather Type Plasma Focus

A 3 kJ Mather type plasma focus system filled with deuterium gas is operated at pressure lower than 1 mbar. Operating the plasma focus in a low pressure regime gives a consistent ion beam which can make the plasma focus a reliable ion beam source. In our case, this makes a good deuteron beam source, which can be utilized for neutron generation by coupling a suitable target. This paper reports ion beam measurements obtained at the filling pressure of 0.05–0.5 mbar. Deuteron beam energy is measured by time of flight technique using three biased ion collectors. The ion beam energy variation with the filling pressure is investigated. Deuteron beam of up to 170 keV are obtained with the strongest deuteron beam measured at 0.1 mbar, with an average energy of 80 keV. The total number of deuterons per shot is in the order of 10¹⁸ cm^?2.