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11.
Serafettin Gunes Yumi Aizawa Takuma Sugashi Masahiro Sugimoto Pedro Pereira Rodrigues 《International journal of molecular sciences》2022,23(9)
Alzheimer’s disease (AD) has become a problem, owing to its high prevalence in an aging society with no treatment available after onset. However, early diagnosis is essential for preventive intervention to delay disease onset due to its slow progression. The current AD diagnostic methods are typically invasive and expensive, limiting their potential for widespread use. Thus, the development of biomarkers in available biofluids, such as blood, urine, and saliva, which enables low or non-invasive, reasonable, and objective evaluation of AD status, is an urgent task. Here, we reviewed studies that examined biomarker candidates for the early detection of AD. Some of the candidates showed potential biomarkers, but further validation studies are needed. We also reviewed studies for non-invasive biomarkers of AD. Given the complexity of the AD continuum, multiple biomarkers with machine-learning-classification methods have been recently used to enhance diagnostic accuracy and characterize individual AD phenotypes. Artificial intelligence and new body fluid-based biomarkers, in combination with other risk factors, will provide a novel solution that may revolutionize the early diagnosis of AD. 相似文献
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Serafettin Alpay Mahmut Yavuz 《Tunnelling and Underground Space Technology incorporating Trenchless Technology Research》2009,24(2):173-184
Underground mining method selection is one of the most important decisions that mining engineers have to make. Choosing a suitable underground mining method to extract a mineral deposit is very important in terms of economics, safety and productivity of mining operations. In real life, underground mining method selection is one of the multiple attribute decision making (MADM) problems and decision makers have always some difficulties in making the right decision in the multiple criteria environment. Analytic hierarchy process (AHP) and Yager’s methods are the MADM tools and can be used for selection of the best underground mining method by considering the problem criteria. In this study, a computer program (UMMS) based on the AHP and the Yager’s method was developed to analyze the underground mining method selection problems and produce the best underground mining method swiftly for different deposit shapes and ore bodies. 相似文献
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Hakan Bilgili Koray Kara Esma Yenel Serafettin Demic Mahmut Kus Sermet Koyuncu 《Color research and application》2020,45(6):1076-1083
In this article, a series of fluorene/2,5-dithenyl-1H-pyrrole-based electroactive polymers (HS-X) with different feed ratio of SC12F/OF were synthesized via Suzuki coupling reactions. Chemical characterization of polymers was elucidated by 1H NMR and Fourier-transform infrared spectroscopy. Electrochemical and electrophysical characterization of the synthesized polymers were investigated by cyclic voltammetry, UV-vis spectroscopy, and fluorescence spectroscopy. Thermal stability of polymers were studied with differential scanning calorimetry and manipulation of the Tg values of HS-X polymers was managed by increasing the numbers of the spiroalkylated fluorene (SAF) moieties incorporated into the polymer backbone. Five different conjugated polymers (HS-1, HS-2, HS-3, HS-4, and HS-5) were used as hole transport layer material in the fabrication of organic light-emitting diode (OLED) devices. The energy levels of the highest occupied molecular orbital as well as the lowest unoccupied molecular orbital and photoluminescence intensities were independent of the number of SAF units. OLED devices based on HS-X polymers were fabricated according to ITO/PEDOT:PSS/HS-X/Alq3/LiF:Al device configuration. Their electroluminescence performances were investigated and the best performance were obtained with the polymer containing 20% SC12F (HS-4) in an OLED device with a turn on voltage of 11.8 V, a maximum luminance of 1202 cd/m2 and a maximum luminous efficiency of 0.30 cd/A compared to other polymers with different feed ratio. 相似文献
14.
Erhan Akkuzu Halil B. Unal Bekir S. Karatas Musa Avci Serafettin Asik 《Canadian Metallurgical Quarterly》2007,133(1):17-26
In this study, an evaluation has been made of the realization level of the planned targets in irrigation planning for all of the 13 water user associations (WUAs) of the Gediz Basin. This evaluation was made according to six performance indicators: level of realization of irrigation ratios, level of realization of crop pattern, dependability, adequacy, efficiency, and equity for the years 1999–2002. Seven associations were successful in irrigation ratio realization, and four were successful in crop pattern. Failure of other WUAs can be reduced by collecting farmers’ declarations and evaluating them with greater care and sensitivity. Water delivery in the general irrigation plan was found to be poor with regard to dependability and equity, and good with regard to the indicators of adequacy (except in the year 2001) and efficiency. In order to improve dependability, the period when water is diverted from the source and the period when water is needed must coincide completely. In order to improve equity, delivery of water to WUAs must be carried out taking account of water requirements predicted in the general irrigation plan. When these two indicators are improved, adequacy and efficiency will improve also. 相似文献
15.
On-the-fly laser drilling requires the use of acceleration continuous trajectories, which are typically planned using time parameterized spline functions. In this operation, the choice of hole drilling sequence, and positioning timings in between the holes, play a critical role in determining the achievable cycle time. This paper presents a new algorithm for sequencing 5-axis on-the-fly laser drilling hole locations and timings. The algorithm considers machine tool and process constraints, as well as the temporal nature of the final commanded spline trajectory. The achievable productivity and motion smoothness improvement are demonstrated in the production of a gas turbine combustion chamber panel. 相似文献
16.
The present study aims to investigate synthesis of Ti3SiC2 from TiO2 and SiO2 powder mixtures by carbothermal reduction method. Equilibrium TiO2–SiO2–C ternary phase diagram was used to predict the conditions for the formation of Ti3SiC2 at 1800 K under Ar atmosphere. A reactant mixture with a TiO2:SiO2 molar ratio of 1.5 and a C content of 68.75 mol% (26.86 wt%) was initially selected among the thermodynamically favorable reactant compositions for the experimental studies. Two different C sources, graphite flakes and pyrolytic C coating, were used to synthesize Ti3SiC2 at 1800 K under Ar atmosphere. When graphite flakes were used, the products contained a trace amount of Ti3SiC2 phase along with major TiC and minor SiC phases. Whereas, pyrolytic C coating on the oxide particles resulted in the products with much higher Ti3SiC2 contents owing to the close contact between the reactants. Optimal C concentration for the C coated oxide mixtures with a TiO2:SiO2 molar ratio of 1.5 was determined to be 30.05 wt% under the experimental conditions studied. Ti3SiC2 content of the products obtained from this reactant was observed to increase with reaction time to 31 wt% at 75 min beyond which it gradually decreased. XRD studies indicated that the product with the highest ternary carbide content also contained TiC and a trace amount of SiC. SEM-EDS analyses showed that this sample essentially consisted of spherical fine TiC particles and Ti3SiC2 nanolaminates. Equilibrium thermodynamic analysis of the TiO2–SiO2–C system suggested that the reaction of solid Ti2O3 with SiO and CO gases may play a dominant role in the formation of Ti3SiC2. 相似文献
17.
In this work, we have investigated the effects of electric and magnetic fields on the operation of a CdS/CuInSe2 photovoltaic cell. Various electric field intensities changing from 0 to 35000 Vdc/m, were applied to the sample while it was irradiated by a He–Ne laser with a wavelength λ=670 nm. As a result, the typical values for the open circuit voltage of the photovoltaic cell significantly changed with various intensities of the electric field Edc. We also applied magnetic fields varying from 0.003 to 0.079 T using a solenoid with an inductance of 10.55 mH and the response of the sample was observed. In the third step of the experiment, instead of the laser beam, various intensities of white light of 50, 100,150 and also 250 lux were utilised. 250 lux was measured to be equivalent to the radiation power of He–Ne laser beam on the surface of the photovoltaic cell. The effect of electric fields from 0 up to 3×105 Vdc was applied and some significant experimental results were obtained. As a result of the illumination of the photovoltaic cell by the stimulated and spontaneous light emission sources under the effect of various intensities of electric field Edc, different electrical behaviours were observed. 相似文献
18.
Thiamine hydrochloride, pyridoxine hydrochloride and calcium‐d‐pantothenate were applied apple juice concentrates (AJC) at various doses in order to reduce the patulin content. AJC samples containing high levels of patulin were stored at 22 ± 2°C and 4°C for 6 months after vitamins were added. Patulin was fully degraded at the end of a 6‐month period in samples stored at 22 ± 2°C, on the other hand, other quality parameters diminished significantly. Without any considerable reduction on other quality parameters, applications of 1000 and 2500 mg/kg calcium‐d‐pantothenate resulted in reduction of patulin of 73.6 and 94.3%, respectively, however, 42.1% of patulin reduction was observed in the control sample of AJC stored for 1 month at 22 ± 2°C. Addition of thiamine hydrochloride (1000 mg/kg( pyrodoxine hydrochloride (625 or 875 mg/kg) and calcium‐d‐pantothenate (1000 or 2500 mg/kg) into the samples and storage at 4°C for 6 months yielded 55.5 to 67.7% of patulin reduction which was only 35.8% for the control, while the other quality parameters were protected adequately. 相似文献
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20.
Dynamics of four-wheel-steering vehicles 总被引:1,自引:0,他引:1
In this paper we present an optimised 3 degrees-of-freedom non-linear dynamic model of a four-wheel-steering (4WS) vehicle. As variables, we retain the lateral velocity V, the rolling velocity p and yaw velocity r. The front steer angle δf and rear steer angle δr are considered to be linear functions of the steering wheel angle θs and of dθs/dt, the proportionality parameters being k 1f, k 2f for δf and k 1r, k 2r for δr. The parameters k 1f, k 2f, k 1r, k 2r are optimised by use of the BOX mathematical algorithm. In a first optimisation loop we minimise the sideslip angle β of the vehicle and in a second optimisation loop we assure, that the resultant (taken in the centre of gravity of the vehicle) of all the transversal forces F y applied on the wheels of the vehicle (reaction forces contained in the road plane), give a component F yx along the longitudinal axis of the vehicle, that takes a non negative value. This assures, that the motor of the vehicle will not waste fuel to overcome resistance forces originating from the steering system of the vehicle. A numerical application is also presented for a 4WS vehicle negotiating a curve at constant velocity. The results are compared to those obtained by two models frequently used in the literature. The comparison testifies on the superiority of our model for the application presented here. 相似文献