Immobilization of Radionuclides in Irradiated Reactor-Graphite Blocks

The immobilization of radionuclides in samples of GR-280 reactor graphite by the fixative atomik is described. A graphite block extracted from RBMK masonry after 17 years of operation is used for the investigations.The investigations showed that the strength of the fixative samples increases only with irradiation doses above 15000 Mrad. The radiation–chemical yield of gaseous products of radiolysis from samples of the fixative under irradiation in vacuum is 12·10^–10 cm³/(g·rad). , , and -emitting nuclides are leached from the samples of irradiated graphite; this process proceeds continually. When the irradiated graphite samples are permeated with the fixative atomik, no release of radionuclides is observed at 20°C for 2 yr.     

Prospects for the development of a direct-flow vessel reactor with superheated steam

A system of new technical solutions, which will make it possible to develop a reactor system using a coolant with supercritical parameters and efficiency 44%, solving the main problems of the nonuniformity of coolant heating in the core, is examined. This sytem contains a core based on fuel micropellets, a multistep fuel assembly with transverse coolant flow, coolant mixing after each step, and continual reloading of fuel micropellets into each fuel assembly. __________ Translated from Atomnaya énergiya, Vol. 100, No. 3, pp. 197–204, March, 2006.     

Preparation of the myristoylated and nonmyristoylated form of recombinant recoverin in E. coli cells and comparison of their functional activity]

Numerous data strongly suggest the involvement of cytokines and the matrix metalloproteinase collagenase (MMP-1) in the pathogenesis of periodontitis. Recently, we have demonstrated that, upon culturing under the influence of IL-1 alpha + EGF, a large amount of inactive procollagenase (MMP-1) is stored in the extracellular matrix of periosteal tissue. We now show that this endogenous reservoir of proenzyme can be operative after activation with plasmin and is able to induce a rapid and almost complete breakdown of the collagenous extracellular matrix. The level of collagen degradation following activation showed a strong correlation with the amount of proenzyme that was incorporated in the tissue. The highest level of degradation (70% of the total amount of collagenous proteins) was found with the IL-1 alpha + EGF-treated explants, followed by those treated with IL-1 alpha alone (35%). Explants cultured with EGF or in the absence of cytokines, containing only small amounts of procollagenase, showed little collagen breakdown following plasmin activation (7%). Inhibition of metalloproteinases by EDTA, or blockage of plasmin by PMSF, prevented the degradation in all explants irrespective of the amount of proenzyme present in the tissue. Our findings demonstrate that endogenous proenzyme stored in a native connective tissue matrix can be activated at a later time interval which results in a massive breakdown of the tissue. This study shows a possible pathway of collagenase-induced breakdown without recent de novo synthesis of the enzyme. Such a sequence may be operative in chronic inflammatory diseases, such as periodontitis, where production of procollagenase under the influence of cytokines spans a longer time period, whereas breakdown is often characterized by a cyclic behaviour.