Butt autogenous laser welding of AA 2024 aluminium alloy thin sheets with a Yb:YAG disk laser

Higher productivity, lower distortion and better penetration are the main advantages provided by laser welding in comparison with conventional processes. A Trumpf TruDisk 2002 Yb:YAG disk laser is used in this work to increases productivity and quality. Aluminium alloys lead to many technological issues in laser welding, resulting in shallow penetration and defects. In particular, AA 2024 aluminium alloy in a thin sheet is investigated in this paper, being it is used extensively in the automotive and aerospace industries. Bead-on-plate and butt autogenous laser welding tests with continuous wave emission on 1.25 mm thick AA 2024 aluminium alloy sheets were examined morphologically and micro-structurally. The geometric and mechanical features of the welding bead were evaluated via a three-level experimental plan. In addition to the power and speed which are traditionally referred to, beam defocusing was considered as an additional governing factor in a central composite design scheme because it massively affects keyhole conditions. Softening in the fused zone is discussed via Vickers micro-hardness testing and magnesium loss through energy dispersive spectrometry. After properly performing the modelling and optimisation of the fused zone and the cross-section shape factor as the response variables, the laser welding conditions for thin sheets of AA 2024 aluminium alloy are suggested. X-ray and tensile tests were conducted on the specimens obtained with the recommended processing parameters to characterise the AA 2024 disk laser welded beads.     

A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands

Based on a medicinal-chemistry-guided approach, three novel series of druglike cycloalkyl-annelated pyrazoles were synthesized and display high affinity (pKi>8) for the sigma1 receptor. Structure-affinity relationships were established, and the different scaffolds were optimized with respect to sigma1 binding and selectivity versus the sigma2 receptor and the hERG channel, resulting in selective compounds that have Ki values (for sigma1) in the subnanomolar range. Selected compounds were screened for cytochrome P450 inhibition (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4), metabolic stability (rat and human liver microsomes), and cell-membrane permeability (Caco-2). They showed favorable in vitro ADME properties as well as favorable calculated druglike and experimental physicochemical properties. Furthermore, compounds 7 f and 17 a, for example, displayed high selectivity (affinity) for the sigma1 receptor against a wide range of other receptors (>60). With these valuable tool compounds in hand, we are further exploring the role of the sigma1 receptor in relevant animal models corresponding to such medicinal indications as drug abuse, pain, depression, anxiety, and psychosis.     

Nondestructive burnup measurements by gamma-ray spectroscopy on spent fuel elements of the RP-10 research reactor

Gamma-ray spectroscopy is an important nondestructive method for the qualification of irradiated nuclear fuels. Regarding research reactors, the main parameter required in the scope of such qualification is the average burnup of spent fuel elements. This work describes the measurement, using nondestructive gamma-ray spectroscopy, of the average burnup attained by Material Testing Reactor (MTR) fuel elements irradiated in the RP-10 research reactor. Measurements were performed at the reactor storage pool area using ¹³⁷Cs as the only burnup monitor, even for spent fuel elements with cooling times much shorter than two years. The experimental apparatus was previously calibrated in efficiency to obtain absolute average burnup values, which were compared against corresponding ones furnished by reactor physics calculations. The mean deviation between both values amounts to 6%.     

Influence of the Substrate on the Formation of Metallic Glass Coatings by Cold Gas Spraying

Cold gas spray technology has been used to build up coatings of Fe-base metallic glass onto different metallic substrates. In this work, the effect of the substrate properties on the viscoplastic response of metallic glass particles during their impact has been studied. Thick coatings with high deposition efficiencies have been built-up in conditions of homogeneous flow on substrates such as Mild Steel AISI 1040, Stainless Steel 316L, Inconel 625, Aluminum 7075-T6, and Copper (99.9%). Properties of the substrate have been identified to play an important role in the viscoplastic response of the metallic glass particles at impact. Depending on the process gas conditions, the impact morphologies show not only inhomogeneous deformation but also homogeneous plastic flow despite the high strain rates, 10⁸ to 10⁹ s^?1, involved in the technique. Interestingly, homogenous deformation of metallic glass particles is promoted depending on the hardness and the thermal diffusivity of the substrate and it is not exclusively a function of the kinetic energy and the temperature of the particle at impact. Coating formation is discussed in terms of fundamentals of dynamics of undercooled liquids, viscoplastic flow mechanisms of metallic glasses, and substrate properties. The findings presented in this work have been used to build up a detailed scheme of the deposition mechanism of metallic glass coatings by the cold gas spraying technology.     

Three strategies to stabilise nearly monodispersed silver nanoparticles in aqueous solution

ABSTRACT: Silver nanoparticles are extensively used due to their chemical and physical properties and promising applications in areas such as medicine and electronics. Controlled synthesis of silver nanoparticles remains a major challenge due to the difficulty in producing long-term stable particles of the same size and shape in aqueous solution. To address this problem, we examine three strategies to stabilise aqueous solutions of 15 nm citrate-reduced silver nanoparticles using organic polymeric capping, bimetallic core-shell and bimetallic alloying. Our results show that these strategies drastically improve nanoparticle stability by distinct mechanisms. Additionally, we report a new role of polymer functionalisation in preventing further uncontrolled nanoparticle growth. For bimetallic nanoparticles, we attribute the presence of a higher valence metal on the surface of the nanoparticle as one of the key factors for improving their long-term stability. Stable silver-based nanoparticles, free of organic solvents, will have great potential for accelerating further environmental and nanotoxicity studies.PACS: 81.07.-b; 81.16.Be; 82.70.Dd.     

Optimization of a thick polyvinyl alcohol-acrylamide photopolymer for data storage using a combination of angular and peristrophic holographic multiplexing

The capability of polyvinyl alcohol-acrylamide photopolymer materials to obtain angularly multiplexed holographic gratings has been demonstrated [Appl. Phys. B 76, 851 (2003)]. A combination of two multiplexing methods--peristrophic and angular multiplexing--is used to record 60 holograms. An exposure schedule method is used to optimize the capability of the photopolymerizable holographic material and obtain holograms with a higher, more uniform diffraction efficiency. In addition, because of this exposure schedule method, the entire dynamic range (M#) of the material will be exploited, obtaining values of approximately M# approximately 9 in layers approximately 800 microm thick.