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71.
Mairobi Persinal-Medina Sara Llames Manuel Chacn Natalia Vzquez Marta Pevida Ignacio Alcalde Sergio Alonso-Alonso Laura María Martínez-Lpez Jesús Merayo-Lloves lvaro Meana 《International journal of molecular sciences》2022,23(9)
The skin is the largest organ in the human body, comprising the main barrier against the environment. When the skin loses its integrity, it is critical to replace it to prevent water loss and the proliferation of opportunistic infections. For more than 40 years, tissue-engineered skin grafts have been based on the in vitro culture of keratinocytes over different scaffolds, requiring between 3 to 4 weeks of tissue culture before being used clinically. In this study, we describe the development of a polymerizable skin hydrogel consisting of keratinocytes and fibroblast entrapped within a fibrin scaffold. We histologically characterized the construct and evaluated its use on an in vivo wound healing model of skin damage. Our results indicate that the proposed methodology can be used to effectively regenerate skin wounds, avoiding the secondary in vitro culture steps and thus, shortening the time needed until transplantation in comparison with other bilayer skin models. This is achievable due to the instant polymerization of the keratinocytes and fibroblast combination that allows a direct application on the wound. We suggest that the polymerizable skin hydrogel is an inexpensive, easy and rapid treatment that could be transferred into clinical practice in order to improve the treatment of skin wounds. 相似文献
72.
Pierre Cornilleau Sergio Guerrero 《Mathematics of Control, Signals, and Systems (MCSS)》2012,24(3):265-294
In this paper we study the controllability of an artificial advection?Cdiffusion system through the boundary. Suitable Carleman estimates give us the observability of the adjoint system in the one dimensional case. We also study some basic properties of our problem such as backward uniqueness and we get an intuitive result on the control cost for vanishing viscosity. 相似文献
73.
Moisés Frías Holmer Savastano Ernesto Villar M. Isabel Sánchez de Rojas Sergio Santos 《Cement and Concrete Composites》2012,34(9):1019-1023
The worldwide production of bamboo generates large volumes of leaf wastes, which are deposited in landfills or burned in an uncontrolled manner, with negative effects in the environment. The ash obtained by calcining of the bamboo leaf waste, shows good qualities as supplementary cementing material for the production of blended cements.The current paper shows a detailed scientific study of a Brazilian bamboo leaf ash (BLA) calcined at 600 °C in small scale condition, by using different techniques (XRF, XRD, SEM/EDX, FT–IR, TG/DTG) and technical study in order to analyse the behaviour of this ash in blended cements elaborated with 10% and 20% by mass of BLA. The results stated that this ash shows a very high pozzolanic activity, with a reaction rate constant K of the order of 10?1/h and type I CSH gel was the main hydrated phase obtained from pozzolanic reaction. The BLA blended cements (10% and 20%) complied with the physical and mechanical requirements of the existing European standards. 相似文献
74.
Giuseppe Della Penna Daniele Magazzeni Sergio Orefice 《Knowledge and Information Systems》2012,30(3):667-692
The Spatial Relation Query (SRQ) tool is a graphical software environment, supported by a SQL-like language, which enables
users to perform information extraction driven by the visual appearance and the spatial arrangement of the information. The
tool has been initially customised to work on specific application domains, like web pages and geospatial data. In this paper,
we present the theoretical formalisation of the visual information extraction (VIE) task and accordingly the redesign of the
SRQ tool, which is now a full-featured, general-purpose information extraction system. Moreover, we show a new application
of the VIE framework to the analysis and visual information extraction from PDF files. 相似文献
75.
76.
Francesco Merola Simonetta Grilli Sara Coppola Veronica Vespini Sergio De Nicola Pasquale Maddalena Cosimo Carfagna Pietro Ferraro 《Advanced functional materials》2012,22(15):3267-3272
Investigation on the behavior of nematic liquid crystals on functionalized polar dielectric crystal substrates is accomplished. Very interesting effects can be observed in maneuvering liquid crystal droplets on the substrate surface, driven by electric fields generated by pyroelectric effect. Reversible drops fragmentation and self‐assembling in different configurations can be achieved. The dynamics of the observed phenomena is studied and the repeatability of the process is full assessed. 相似文献
77.
78.
We study composite materials in which single‐crystalline magnetic shape‐memory particles are embedded in a polymer matrix, in the limit of particles much larger than the typical domain size. We first derive an effective macroscopic model, using the mathematical theory of relaxation, and then solve it numerically for practically relevant parameters, and compare with experimental results. 相似文献
79.
Sergio Scognamillo Emilia Gioffredi Massimo Piccinini Massimo Lazzari Valeria Alzari Daniele Nuvoli Roberta Sanna Daniele Piga Giulio Malucelli Alberto Mariani 《Polymer》2012,53(19):4019-4024
Thermoplastic polyurethane (TPU) nanocomposites containing graphene and graphene nanoribbons were obtained by polymerizing 1,4-butanediol with two diisocyanates (namely, 1,6-hexane diisocyanate or isophorone diisocyanate), in which the nanofillers were previously dispersed. Raman spectroscopy and Transmission Electron Microscopy demonstrated the formation of few-layer graphene and graphene nanoribbons dispersed in the monomers. At variance to the methods commonly reported in literature, that used in this work consists of the direct exfoliation of graphite without any chemical manipulation. Apart from the obvious cost and ease advantages, the so-obtained graphene does not contain any carboxy or alkoxy groups formed during the exfoliation process, which, at variance, are typically present in the most commonly reported methods. This finding paves the way toward the large-scale production of graphene and its nanoribbons, which are considered even more interesting than graphene itself for many potential applications. The obtained nanocomposites show a peculiar thermal and rheological behavior due to the presence of the nanofillers and to their reinforcing or plasticizing effect exerted on the TPU matrices. 相似文献
80.
We have shown that it is possible to tune, up to complete suppression, the photoluminescence superlinear dependence on the excitation density in quantum dot samples at high temperatures by annealing treatments. The effect has been attributed to the reduction of the defectivity of the material induced by annealing. 相似文献