Tent-Shaped Surface Morphologies of Silicon: Texturization by Metal Induced Etching

Silicon - Nano-metal/semiconductor junction dependent porosification of silicon has been studied here. The silicon nanostructures (SiNSs) have been textured on n- and p- type silicon wafers using...     

The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers

This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects could not be evaluated in human studies as prospective trial data is lacking. However, retrospective studies show a decreased incidence of PCa in males exposed to α-antagonists. As human data evaluating the use of α-antagonists as treatments are lacking; well designed, prospective clinical trials are needed to conclusively demonstrate the anticancer properties of quinazoline based α-antagonists in PCa and other cancers.     

Investigation of N + SiGe Gate Stacked V-TFET Based on Dopingless Charge Plasma for Gas Sensing Application

Silicon - In this paper, a novel n + SiGe pocket layer gate stacked VTFET doping less charge plasma is proposed and analyzed using Silvaco TCAD simulation software. The proposed device...     

Design and Investigation of SiGe Heterojunction Based Charge Plasma Vertical TFET for Biosensing Application

Silicon - This paper explores the Vertical tunnel FET with the introduced layer of SiGe within the channel/source junction using TCAD. As Tunnel FETs smothered the 60 mV/decade confinement...     

Analytical and Compact Modeling Analysis of a SiGe Hetero-Material Vertical L-Shaped TFET

Silicon - This paper deals with the development of a novel 2-D analytical modeling of heterojunction vertical L-shaped tunnel FET for characterisation of surface potential and drain current. The...     

Investigation of Power on Silicon Adiabatic for VLSI Applications

Silicon - In this article, a novel silicon adiabatic circuit is proposed for low power applications. To achieve efficient performance, the charging and the discharging diodes in the energy recovery...     

Perspective study of abrasive water jet machining of composites — a review

Journal of Mechanical Science and Technology - Even though composite materials are prominent amongst the advanced engineering materials, but machining of composites using conventional machining...     

Triaxiality at crack tip for combined Lankford's coefficient and degree of anisotropy subjected to mixed-mode (I/II) fracture

Structural parts used in boilers, turbines, ships, and many household purposes are manufactured through sheet metal forming processes. During manufacturing, the micro structure of the material is deformed and micro cracks along with anisotropic properties get induced. Present research deals with a thin sheet metal plate containing a central crack subjected to mixed mode (I+II) loading. With special reference to Lankford's coefficient and degree of anisotropy, the effect of anisotropic triaxiality on crack initiation angle has been investigated. The result reveals the combinations of Lankford's coefficient and degree of anisotropy for which crack initiation angle do not change.     

Exact solutions for characterization of electro-elastically graded materials

The present paper deals with a class of functionally graded materials (FGM), called active FGM that has electro-elastically graded material phases. An active FGM system leads to minimization of stress concentration that arises due to mismatch in the electrical and elastic properties of the constituent phases. This work focuses on the characterization of the through thickness stresses of an active FGM subjected to electrical excitation. The structure is comprised of a substrate, an electro-elastically graded layer and an active layer. A formulation for exact solutions of the system based on Euler–Bernoulli theory is presented. Power-law variation of the composition of the two phases in the graded layer is considered. Performance of linearly gradient FGM for a range of stiffness and electrical property ratios of the active and substrate materials have been studied. It is observed that the electrical strain component and the compositional gradation significantly influence the stress characteristics of the active FGM.