Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates

Resistance-modifying agents (RMAs) such as Verapamil have been proved to be effective in reversing multi-drug resistance (MDR) in many in vitro assays. In this study we have investigated the efficacy of Dex-Verapamil, the R-isomer of Verapamil, as a chemosensitizer in a murine leukemia cell line (P388) and in its resistant counterpart (P388/Dx) expressing a typical MDR phenotype. We have examined in vivo the effect of the co-administration of Dex-Verapamil and Doxorubicin in mice transplanted with P388 or P388/Dx cells. Mice treated with the combination of Doxorubicin plus RMA had a significant increase in survival rate as compared to controls; however, the effect was modest. On the contrary, in vitro Dex-Verapamil can enhance Doxorubicin cytotoxicity in P388/Dx cells with a much greater effect depending on the treatment scheme used, by increasing the intracellular content of drug. Taken together our data indicate that Dex-Verapamil can indeed increase the sensitivity to Doxorubicin in resistant cells, but the limited efficacy shown in vivo demonstrates that this phenomenon is strongly dependent on the treatment scheme used and on the maintenance of constantly elevated serum levels.     

连续式棒线材轧机孔型系统的选择

论述了连续式棒线材轧机孔型系统的种类和特点，介绍了粗轧机组和中轧机组孔型系统的选择原则和方法。     

对新闻专业主义“现实性”的思考

新闻专业主义在西方拥有很大的理论市场,但这一理念所具有的理想主义色彩也不容忽视。多年来,新闻专业主义在其发展过程中不断受到严峻的现实挑战。本文分析了新闻媒体新闻专业主义缺失的深层原因,认为政治权力和市场机制等制度性框缚是新闻专业主义难以发挥其预期效果的根源所在。同时指出,新闻专业主义并非新闻改革的唯一出路。     

用熵方程证明全不可逆循环揭示的Clausius方程式

利用不可逆循环图代替传统的半不可逆循环推导出Clausius积分式，并用熵方程证明之，得出可逆过程膨胀功大于不可逆过程膨胀功。     

2005，十大危险入侵主妇厨房

食品安全．在2005年中仍然纷纷扰扰：食品与家庭每个成员的健康息息相关，而维护全家人的健康，则是女主人义不容辞的责任。我们一起来听听．于她们而言．2005年最关心的食品安全问题是什么？[编者按]     

如何辨别电影画原底片的优劣

本文提供一个简便实用的质量鉴定方法,用于在制作发行拷贝前,辨别电影画原底片的优劣。     

Study on phase behavior–impact strength relationship of unsaturated polyester/polyurethane hybrid polymer network

The phase behavior of a hybrid polymer network (HPN) composed of poly[(propylene glycol maleate)-co-(propylene glycol phthalate)] crosslinked with styrene and polyester–urethane crosslinked with methylene-bis-ortho-chloroaniline was examined. The correlation between phase separation and impact strength of the HPNs is discussed. The composition of HPNs has an effect on their properties.     

70推土机主离合器分离杆螺栓失效分析

主离合器分离杆螺栓是一个重要安全件，使用中经常发生断裂。经过失效分析确定断裂原因是由其配件引起。提高配件的冷加工质量及改进结构，可解决分离杆螺栓的断裂问题。     

大力发展循环经济实现企业可持续发展

莱钢始建于1970年1月,现控股莱钢股份、鲁银投资两个上市公司及齐鲁证券等25个子公司。莱钢是中国冶金行业首批通过ISO9002质量管理体系、ISO14001环境管理体系和OHSAS18001职业安全健康管理体系国家认证的企业。2005年,莱钢被国家发改委确定为国家第一批循环经济试点单位。