Strategic allocation of inspection stations for a flow assembly line: a hybrid procedure

A hybrid method is presented for the design of inspection stations in serial production systems. The hybrid method combines a constrained bottleneck shortest path algorithm and discrete event simulation. The network method determines the allocation of the inspection stations and the simulation helps the decision maker estimate accurately the possible outcome of the allocation. A computational study with the method is performed based on a practical problem. Other aspects related to the application of the method to real problems are also discussed.     

Diffraction by an arbitrary-angled dielectric wedge. II. Correctionto physical optics solution

For pt.I see ibid., vol.39, no.9, p.1272-81 (1991). The error of the physical optics solution for the E-polarized plane wave incidence in connection with diffraction by an arbitrary-angled dielectric wedge is corrected by calculating the nonuniform current distributed along the dielectric interfaces. Two kinds of series expansions to the nonuniform current are employed. One is an asymptotic expansion as the multipole line source located at the edge of the dielectric wedge, since the correction field seems to be a cylindrical wave emanating from the edge in the far-field region. The other is arbitrary electric and magnetic surface currents expanded by infinite series of the Bessel functions, i.e. the Neumann expansion, of which fractional order is chosen to satisfy the edge condition near the edge of the dielectric wedge in the static limit. Both of the two different expansion coefficients for a wedge angle of 45°, relative dielectric constants 2, 10, and 100, and the E-polarized incident angle of 150° are evaluated by solving the dual series equation numerically after finite truncation     

Application of phase-stabilized optical fiber in transmission ofreference and IF signals in VLBI observation

A phase-stabilized optical fiber (PSOF) cable, which is 880 m long, was successfully used to transmit a 100-520 MHz IF signal and 10 MHz reference frequency signal in Mark III very long baseline interferometry (VLBI) observations. Phase stability of the 1760-m round-trip PSOF cable was measured by a dual mixer time difference system. Results of the measurements show that the stability of the PSOF cable system is about 50 times better than that of an ordinary coaxial cable system. The measured phase fluctuations are smaller than the tolerance limit required for a coherence loss of less than 20% in VLBI observations with an integration time of several hundred seconds. Internal accuracies of the international geodetic VLBI observations, in which the PSOF cable system is used at a station, are proven to be in the level of the present-day standard. The results show that the performance of the cable is at least comparable with, and probably better than, that of coaxial cables of much shorter length widely used in VLBI stations     

Contention-Based Airtime Usage Control in Multirate IEEE 802.11 Wireless LANs

In a multirate wireless LAN, wireless/mobile stations usually adapt their transmission rates to the channel condition. It is difficult to control each station's usage of network resources since the shared channel can be overused by low transmission-rate stations. To solve this problem, we propose a distributed control of stations' airtime usage which 1) always guarantees each station to receive a specified share of airtime, and 2) keeps service for individual stations unaffected by other stations' transmission rates. Such airtime control enables service differentiation or quality of service (QoS) support. Moreover, it can achieve a higher overall system throughput. The proposed airtime usage control exploits the Enhanced Distributed Channel Access (EDCA) of the IEEE 802.11e standard . Two control mechanisms are proposed: one based on controlling the station's arbitration inter-frame space (AIFS) and the other based on the contention window size. We show how the stations' airtime usage is related to the AIFS and contention window size parameters. Using this relation, two analytical models are developed to determine the optimal control parameters. Unlike the other heuristic controls or analytical models, our model provides handles or parameters for quantitative control of stations' airtime usage. Our evaluation results show that a precise airtime usage control can be achieved in a multirate wireless LAN     

Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous azosemide

The effects of differences in the rate and composition of intravenous fluid replacement for urine loss on the pharmacokinetics and pharmacodynamics of azosemide were evaluated using rabbit as the animal model. Each rabbit received a 4h constant intravenous infusion of 1 mg kg-1 azosemide with 0% replacement (treatment I, n = 4), 50% replacement (treatment II, n = 5), and 100% replacement (treatment III, n = 5) with lactated Ringer's solution, as well as with 100% replacement with 5% dextrose in water (D-5-W, treatment IV; n = 5). Renal clearance and urinary excretion rate of the drug in treatment III were considerably higher than those in treatments I, II, and IV. In spite of the similarities in kinetic properties, diuretic and/or natriuretic effects of azosemide were markedly different among the four treatments. For example, the mean 8 h urine output values were 98.2, 178, 733, and 237 mL for treatments I-IV, respectively, and the corresponding values for sodium excretion were 11.1, 19.4, 76.4, and 14.2 mmol, and for chloride 13.4, 23.8, 78.9, and 17.1 mmol. Except for treatment III, diuresis and/or natriuresis were found to be time dependent, generally decreasing with time until reaching a low plateau during the later hours of infusion. The present findings also show that (i) no fluid replacement and 100% replacement with D-5-W both produce the same degree (not significantly different) of severe acute tolerance in natriuresis, indicating the insignificance of water compensation in tolerance development; (ii) in treatment II, where neutral sodium balance was achieved, the development of acute tolerance in diuresis can mainly be attributed to negative water balance under this special condition; and (iii) at steady state the hourly diuresis and natriuresis can differ up to about 6.87- and 5.21-fold between treatments. Some implications for the bioequivalence evaluation of dosage forms of azosemide are discussed.     

Detection of antibodies to melanocytes in vitiligo by western immunoblotting

To more fully define the nature of the antibody response to melanocytes which is associated with vitiligo, a Western immunoblot assay was used to test the sera of 28 patients with vitiligo (21 with active non-segmental, and 7 with stable segmental diseases) and 26 normal individuals for antibodies to antigens in detergent extracts of melanocyte membrane fractions. Antibodies to melanocytes were found in 26 (93%) of the patients with vitiligo, and in 16 (62%) of the control individuals. Patients with vitiligo and control individuals both had antibodies to an 80 approximately 83 kD antigen. The patient with vitiligo, in addition, had antibody responses to antigens with MWs of 45, 65, and 110 kD. Antibodies to these antigens were present in 46, 25, and 31% of vitiligo patients, but in only 19%. 0%, amd 0%, respectively, of the normal individuals. The heterogeneity of the antibody responses to melanocytes in vitiligo was further confirmed by the presence of antibodies to at least 3 distinct antigens in one-third of vitiligo patients but in none of the normal individuals. There was no difference in antibody response between patients with generalized and segmental vitiligo, suggesting that the pathogenesis of diseases was similar in both cases.     

A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats

The modifying effect of dietary administration of a xanthine oxidase inhibitor 1'-acetoxychavicol acetate (ACA) present in an edible plant Languas galanga in Thailand on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in rats. Male F344 rats were given s.c. injections of AOM (15 mg/kg body wt) once a week for 3 weeks to induce colonic ACF. They were fed the diets containing 100 or 200 ppm ACA for 5 weeks, starting 1 week before the first dosing of AOM. At the termination of the study (week 5), AOM induced 118 +/- 28 ACF/colon. Dietary administration of ACA caused significant reduction in the frequency of ACF (41% inhibition by 100 ppm ACA feeding and 37% inhibition by 200 ppm ACA feeding, P<0.01). Such inhibition might be associated with suppression of the proliferation biomarkers' expression such as ornithine decarboxylase activity in the colonic mucosa, number of silver-stained nucleolar organizer regions' protein in the colonic mucosal cell nuclei and blood polyamine content. These results indicate that ACA could inhibit the development of AOM-induced ACF through its suppression of cell proliferation in the colonic mucosa and ACA might be a possible chemopreventive agent against colon tumourigenesis.     

Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy

BACKGROUND: The goal of chemoprevention is to reduce the risk of cancer development by reversing or blocking the tumorigenic process through the use of pharmacologic or natural agents. To determine the potential role of genetic alterations in assessing cancer risk and in evaluating the efficacy of chemopreventive agents, we studied 22 patients with advanced premalignant lesions of the head and neck who were part of a prospective cancer prevention trial that is investigating a regimen of 13-cis-retinoic acid, interferon alfa, and alpha-tocopherol administered for 12 months or until disease progression. METHODS: We used polymerase chain reaction analysis of microsatellite DNA sequences in cells from precancerous lesions to determine the frequencies of genetic alterations--namely, loss of heterozygosity (LOH) and microsatellite instability--at chromosomal loci that are commonly deleted in head and neck cancer. RESULTS: Prior to treatment, 17 (81%) of 21, eight (44%) of 18, and eight (42%) of 19 patients who were informative (i.e., heterozygous) at chromosomes 9p21, 3p14, and 17p13, respectively, exhibited LOH in at least one of their lesion biopsy specimens. Among nine patients who exhibited LOH at chromosome 9p21 in pretreatment biopsy specimens and who had completed at least 5 months of therapy, the genetic loss persisted in eight--including three of the four patients who exhibited complete histologic responses (i.e., no evidence of dysplasia in their biopsy specimens). IMPLICATION: Our data suggest that clinical and histologic assessments of the response to chemopreventive agents may be insufficient to determine their efficacy and that critical genetic alterations could be used as independent biomarkers to augment the ability to evaluate the efficacy of such agents.     

Integrated optical waveguide polarizer based on photobleaching-induced birefringence in an electrooptic polymer

A TE-pass waveguide polarizer is fabricated by utilizing the photobleaching-induced birefringence at room temperature in an electrooptic polymer. The polarizer consists of the photobleached waveguide supporting only TE mode, which is integrated in the middle of the etched rib waveguide supporting both TE and TM modes. It has a simple structure and requires no high temperature process like poling. The measured polarization extinction ratio is about 21 dB at the wavelengths of 1.3 and 1.55 /spl mu/m, and the estimated excess loss is about 0.4 dB.