Development of a novel system to quantify the spatial–temporal parameters for crutch-assisted quadrupedal gait

Abstract

Patients with gait disorders often use bilateral crutches along with their own two legs. It is a kind of quadrupedalism. Crutch-assisted gait is usually described and evaluated qualitatively. In this study, we developed a system to quantify the spatial and temporal parameters for crutch-assisted quadrupedalism. Our system consists of walkway hardware and our originally developed software. We specifically extended the measurable area to 1200 mm × 4800 mm, large enough to measure crutch gait. Using our system, we could describe crutch gait precisely. Our system has a capability to evaluate differences between patients and changes within a patient.     

Some generalized sufficient convergence criteria for nonlinear continuous neural networks

A reason for applying the direct method of Lyapunov to artificial neural networks (ANNs) is to design dynamical neural networks so that they exhibit global asymptotic stability. Lyapunov functions that frequently appear in the ANN literature include the quadratic function, the Persidskii function, and the Luré-Postnikov function. This contribution revisits the quadratic function and shows that via Krasovskii-like stability criteria, it is possible to have a very simple and systematic procedure to obtain not only new and generalized results but also well-known sufficient conditions for convergence established recently by non-Lyapunov methods, such as the matrix measure and nonlinear measure.     

Isolation and identification of soil bacteria resistant to surfactants in washing detergents

Linear alkylbenzene sulfonate (LAS) and polyoxyethylene lauryl ether (POLE) are the major surfactants in washing detergents. In the present study, we isolated surfactant-resistant bacteria from soil samples collected from a sports ground and a farm field. The samples were treated with 2.0% LAS or POLE at 25°C for 30 min and cultivated on agar plates at 25°C for several days, after which manifold bacterial colonies were isolated. Thereafter, we tested the ability of each bacterial isolate to resist the antibacterial activity of the surfactant. Ten LAS-resistant strains were isolated, and all were found to be Gram-negative bacteria such as Enterobacter and Pseudomonas. On the other hand, 18 POLE-resistant strains were isolated, of which 14 were Gram-positive bacteria including Bacillus and Microbacterium. Notably, one POLE-resistant strain was identified as Bacillus cereus, a potential causative agent for foodborne illness. The genera of LAS- and POLE-resistant bacteria did not overlap. Therefore, the combination of LAS and POLE could be more effective to eliminate soil bacteria from clothes and/or daily necessities.     

Corneal critical barrier against the penetration of dexamethasone and lomefloxacin hydrochloride: evaluation by the activation energy for drug partition and diffusion in cornea

The cornea is a solid barrier against drug permeation. We searched the critical barrier of corneal drug permeation using a hydrophobic drug, dexamethasone (DM), and a hydrophilic drug, lomefloxacin hydrochloride (LFLX). The activation energies for permeability of DM and LFLX across the intact cornea were 88.0 and 42.1 kJ/mol, respectively. Their activation energies for permeability across the cornea without epithelium decreased to 33.1 and 16.6 kJ/mol, respectively. The results show that epithelium is the critical barrier on the cornea against the permeation of a hydrophobic drug of DM as well as a hydrophilic drug of LFLX. The activation energy of partition for DM (66.8 kJ/mol) was approximately 3-fold larger than that of diffusion (21.2 kJ/mol). The results indicate that the partition for the hydrophobic drug of DM to the corneal epithelium is the primary barrier. Thermodynamic evaluation of activation energy for the drug permeation parameters is a good approch to investigate the mechanism of drug permeability.     

Hybrid fiber amplifiers consisting of cascaded TDFA and EDFA for WDM signals

The detailed gain characteristics of hybrid fiber amplifiers that consist of cascaded thulium-doped fiber amplifiers (TDFAs) and erbium-doped fiber amplifiers (EDFAs) are reported. The experimental results showed that the hybrid amplifiers have gains of over 20 dB with the bandwidth of more than 80 nm in the wavelength range between 1460 and 1560 nm. The low noise figure (NF) below 7 dB was obtained in 1460-1540 nm when placing a TDFA in the first stage followed by an EDFA and in 1480-1560 nm when placing amplifiers in a reversed order. The gain of TDFA and EDFA was optimized for minimizing the gain variation ratio (GVR=(maximumgain-minimumgain)/minimumgain: in the unit of decibels) of the hybrid amplifiers, and it could be minimized to less than 0.4 for the amplifiers that have gain in the wavelength region from 1460 to 1537 nm. The gain-equalization technique was applied, and the hybrid amplifier that had an average gain of 20 dB, a gain excursion of less than 2 dB, an output power of 14.5 dBm, and an NF of less than 7 dB in the 77-nm gain band was achieved.     

Optimal design of linear control systems by an interactive optimization method

When designing linear control systems, one of the most difficult problems is that the designer almost has no theoretical basis for the determination of proper parameters in order to obtain a system with desired specifications. Poles and directions of eigenvectors in the pole assignment method or weighting matrices of the quadratic criterion function in the optimal regulator method are such parameters. The designer has to determine them by trial-and-error using computer simulation. The purpose of this paper is to propose an approach to helping determine proper parameters in linear control system design by the state space methods. In the case where the desired specifications are not given explicitly, the approach applies an interactive optimization method called the Interactive Simplex method to search the most suitable parameters directly in the parameter space. But, if the specifications are given explicitly, the design problem can be formulated as a multiobjective optimization problem. In this case, weights which indicate relative importance of different specifications are introduced and the Interactive Simplex method is applied in the weight space to indirectly find the most appropriate parameters. The approach is implemented as part of a CAD system. The designer has only to make pairwise comparisons of response curves which are shown on a graphics display terminal in order to obtain the most preferred control system. Two illustrative examples are demonstrated to indicate the efficiency of the approach.     

Inorganic-organic hybrid molecular architectures of cyanometalate host and organic guest systems: specific behavior of the guests

Molecular architectures built of inorganic cyanometalate building blocks provide variegated host structures with several organic guest molecules. The strategies to derive novel structures are presented briefly. The formation of a charge-transfer (CT) complex as the guest inside the cavity and the photochemistry of the CT complexes are discussed. The chemical pressure that the guest experiences inside the cavity is also discussed based on the vibrational spectroscopic results.     

In situ observation of freeze-fractured and deep-etched red blood cells with a high-vacuum low-temperature atomic force microscope

A high-vacuum low-temperature atomic force microscope (AFM) for the direct observation of freeze-fracture samples has been developed. This AFM has a freeze-fracture mechanism inside the vacuum chamber. With this AFM it is possible to observe the fractured surface directly without both fabricating a replica and exposure to the ambient atmosphere. Both sandwich and knife fracture methods have been achieved to obtain freeze-fracture surfaces and after deep etching. A fine structure of the fractured red blood cell membrane has been observed using both methods. These are relatively quick and easy methods for the observation of freeze-fracture surfaces without introducing replica artifacts.