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11.
The so called Geographical Information System (GIS) is one of the basic tools for wide range of public health applications. We had developed a general purpose GIS and applied it to represent geographical distribution of patients of the bacterium E. coli O-157 which bursted out in Japan last early summer particularly at Sakai City in Osaka Prefecture. The patient record have been supplied from the Food Safety Office of the Ministry of Health and Welfare. These records were handled by EXCEL. The basic geographical data was constructed from the map data provided by Japan Geographical Survey Institute, and ArcView 2 was used as the map system. The maps were converted to Graphics Interchange Format (GIF) files and put on our Web server. 相似文献
12.
N Mamiya JR Goldenring Y Tsunoda IM Modlin K Yasui N Usuda T Ishikawa A Natsume H Hidaka 《Canadian Metallurgical Quarterly》1993,195(2):608-615
A novel Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) inhibitor, KN-93 potently inhibits gastric acid secretion from parietal cells. As previously reported (1), treatment of parietal cells with a selective inhibitor of CaM kinase II, KN-62 resulted in the inhibition of cholinergic-stimulated rabbit parietal cell secretion, whereas it failed to inhibit the histamine and forskolin response. In contrast effects of carbachol, histamine and forskolin were significantly inhibited by KN-93 with an IC50 of 0.15, 0.3 and 1 microM, respectively; these effects occurred without any changes in intracellular cyclic AMP and Ca2+ levels. In the present study we investigated the mechanism by which KN-93 acts upon the acid-secreting machinery of gastric parietal cells. Neither redistribution of the proton pump activity nor the morphological transformation were affected by KN-93. The drug only weakly inhibited the H+, K(+)-ATPase activity but strongly dissipated the proton gradient formed in the gastric membrane vesicles and reduced the volume of luminal space. Thus KN-93 acts at pH gradient formation whereas KN-62 acts only at CaM Kinase II. 相似文献
13.
Motofumi Suzuki Kohei Kinoshita Shinji Jomori Hidehiko Harada Kaoru Nakajima Kenji Kimura 《Thin solid films》2007,515(22):8281-8284
The initial stage of iron silicide formation is investigated by high-resolution Rutherford backscattering spectroscopy. During the Fe deposition on Si(001) at 470 °C, the formation of FeSi2 is confirmed by the surface peak analysis. Initially, FeSi2 grows epitaxially so that one of the major crystallographic axes is parallel to the <111> axis of the Si substrate. With increasing Fe deposition, the deviation between the major crystallographic axis of the silicide region and Si<111> increases although the electron diffraction pattern is independent of the amount of Fe deposition. Therefore, the subsurface crystallographic structure of iron silicide is transformed from a cubic-like to a low-symmetry structure. 相似文献
14.
Usami K. Igarashi M. Minami F. Ishikawa T. Kanzawa M. Ichida M. Nogami K. 《Solid-State Circuits, IEEE Journal of》1998,33(3):463-472
This paper describes an automated design technique to reduce power by making use of two supply voltages. The technique consists of structure synthesis, placement, and routing. The structure synthesizer clusters the gates off the critical paths so as to supply the reduced voltage to save power. The placement and routing tool assigns either the reduced voltage or the unreduced one to each row so as to minimize the area overhead. The reduced supply, voltage is also exploited in a clock tree to reduce power. Combining these techniques together, we applied it to a media processor chip. The combined technique reduced the power by 47% in random-logic modules and by 73% in the clock tree, while keeping the performance 相似文献
15.
This paper deals with an advanced static Var compensator (ASVC) using quad-series voltage-source PAM inverters. The ASVC consists of four three-phase voltage-source inverters with a common dc capacitor and four three-phase transformers, each primary winding of which is connected in series with each other. Each inverter outputs a square-wave voltage, while the synthesized output voltage of the ASVC has a 24-step wave shape. This results not only in a great reduction of harmonic currents and dc voltage ripples but also in fewer switching and snubbing losses. In this paper, transient analysis is performed with the focus on the response of reactive power and the resonance between the dc capacitor and ac reactors. Experimental results obtained from a small-rated laboratory model of 10 kVA are also shown to verify analytical results based on the p-q transformation. The analytical results help in the design of system parameters such as the capacity of the dc capacitor and feedback gains. 相似文献
16.
Tomiji Wakida Muncheul Lee Yukihiro Sato Shinji Ogasawara Yi Ge Shouhua Niu 《Coloration Technology》1996,112(9):233-236
Wool and nylon 6 fibres treated with oxygen low-temperature plasma were dyed with acid and basic dyes. Despite the increase of electronegativity of the fibre surface caused by the plasma treatment, the rate of dyeing of wool was increased with both dyes, while that of nylon 6 was decreased with the acid dye and increased with the basic dye. 相似文献
17.
18.
Cutaneous lesions caused by M. ulcerans were shown to bear only a superficial resemblance to those produced by certain spider species. M. ulcerans was not found in either the venoms or the midguts of several Australian spiders, and deliberate contamination by inoculation of the fangs and digestive system of the wolf spider, Lycosa godeffroyi, did not result in permanent colonization. M. ulcerans was successfully introduced into the skin of mice through a small trauma site similar to that caused by a spider bite. However, because M. ulcerans was shown to survive on exposed surfaces for only a short period, a successful inoculation is likely only if the skin is contaminated with this organism after, or at the same time as, the skin suffers damage. The claim by other workers that M. ulcerans produces cutaneous ulcers by release of an exotoxin could not be confirmed. The authors conclude that M. ulcerans is not involved in most cases of necrotic arachnidism and hence there is no justification for prescribing anti-mycobacterial antibiotics to resolve alleged spider bite lesions unless the presence of M. ulcerans has been demonstrated by appropriate laboratory tests. 相似文献
19.
T Kimura I Haruta Y Isobe E Ueno J Toda Y Nemoto K Ishikawa Y Miyazono K Shimizu K Yamauchi N Hayashi 《Canadian Metallurgical Quarterly》1997,92(5):883-886
We present a patient with continuous melena, diagnosed as rectal varices bleeding. She had a history of esophageal varices, which was treated by endoscopic ligation therapy. Eight years after the treatment of esophageal varices, the continuous melena began. Colonoscopic examination showed that the melena was caused by rectal varices, which were so severe that they could not be treated by either endoscopic sclerotherapy or surgical devascularization. Taking into considering the overall risk of treating rectal varices, we chose the approach of double balloon-occluded embolotherapy (DBOE) with 5% ethanolamine oleate with iopamodol as a liquid embolic material. DBOE is one of the interventional radiology techniques (Morita et al., Acta Hepatol Jpn 1994;35:109-120), but in this case was a completely new and novel clinical procedure for rectal varices. After the DBOE therapy, the condition of rectal varices was markedly improved. Thus, DBOE might be a new tool for treating inoperable rectal varices. 相似文献
20.
Toshiji Mukai Koichi Ishikawa Kenji Higashi 《Metallurgical and Materials Transactions A》1995,26(10):2521-2526
Three IN905XL aluminum alloys with fine grain (1 μm), intermediate grain (3 μm), and coarse grain (5 μm) have been developed
by a combination of mechanical alloying (MA) and conventional extrusion in order to investigate their mechanical properties
at dynamic strain rates of 1 × 103 and 2 × 103 s−1 and a quasi-static strain rate of 10-3 s−1. Flow stresses are found to increase with decreasing grain size for all the strain rates tested. Negative strain-rate sensitivity
of flow stress is observed up to 1 × 103 s−1 in both intermediate- and coarse-grained IN905XL. At the highest strain rate of 2 × 103 s−1 however, all samples showed a positive strain-rate sensitivity of strength. Total elongation at high strain rates is generally
larger than that at low strain rates. Total elongation also decreases with grain size for all the strain rates. This decrease
in elongation results from an initiation of microcracks at interfaces between the matrix and particles finely dispersed near
grain boundary regions, introduced during MA processing; then, this initiation leads elongation of alloys to small limited
values.
Formerly with the Department of Mechanical Systems Engineering, University of Osaka Prefecture.
This article is based on a presentation made in the symposium “Dynamic Behavior of Materials,” presented at the 1994 Fall
Meeting of TMS/ASM in Rosemont, Illinois, October 3-5, 1994, under the auspices of the TMS-SMD Mechanical Metallurgy Committee
and the ASM-MSD Flow and Fracture Committee. 相似文献