New tetrapolar circuit method using magnetic field for measurementof local impedance change in biological substances

A new tetrapolar circuit method using a magnetic field is proposed to measure the local electric impedance change in living tissue. Based on this method, we designed an apparatus which can detect impedance changes in closely-situated two parts of living tissue, simultaneously and independently. Using this apparatus, we showed the effectiveness of the proposed method by an in vitro experiment and by an in vivo measurement of pulsatile waveforms in the forearm arteries. The detection sensitivity for a local impedance change was confirmed to be higher than that of the conventional tetrapolar method. Pulsatile impedance waveforms measured in the radial and the ulnar parts of the forearm were consistent with those estimated from the anatomical structure.     

Preparation of micrometer‐sized,multifunctional capsule particles for cosmetic by microsuspension polymerization utilizing the self‐assembling of phase separated polymer method

Micrometer‐sized polymer particles with encapsulated ultraviolet (UV) absorbent, fluorescent agent, and blue pigment were successfully prepared by microsuspension polymerization utilizing the Self‐assembling of Phase Separated Polymer method. The particles were characterized by optical microscope and particle size distribution analysis, and they were evaluated on their usefulness for cosmetic using UV spectrometry, colorimetry, VISIA? Evolution, and bioassay. The capsule particles had multifunctional properties, which are very attractive in the cosmetic field, especially in whitening, brightening, the improvement of face‐texture, and less noticeable pores in face, as well as the protection from UV. Moreover, bioactivities of the particles under the UV irradiation, which were examined with the films prepared from capsule components, revealed not only makeup effect but also the activation of human epidermal keratinocytes. The results suggest the importance of blue light in the field of cosmetics. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013     

Apolipoprotein (a)

Apo (a) consists of multiple tandem repeat of kringle 4, which resembles a counterpart of plasminogen. Plasma Lp (a) levels are genetically determined primarily by alleles at the apo (a) gene. Apo (a) shows size heterogeneity on the analysis of the protein and the mRNA. Pulse field gel electrophoresis revealed that size heterogeneity is largely due to different numbers of kringle 4-encoding sequences in the apo (a) gene. The cloning of apo (a) gene and identification of the 5'-flanking promoter region provide tools to study the regulation of apo (a) gene. The development of transgenic mice expressing human apo (a) offered a good model for understanding of atherosclerosis associated with elevated plasma levels of Lp (a).     

Current distribution in superconducting multistrands for ac use before and after quenching

A superconducting multistranded cable is used to realize high current capacity for ac use. The critical current value of the cable is reported to be less than the simple summation of the individual critical current value of each strand. The causes for such a degradation of the critical current value have not been revealed. This paper investigates the current distribution in multistrands before and after their quenching by using seven-strand superconducting cable and 7x7 cable. The following experimental results are derived: (1) the quenching is initiated at one strand in the cable; (2) the current in the quenched strand is transferred into the other strands; (3) an avalanche of quenching is induced among the strands; and (4) the central strand is quenched finally among the strands. The critical current values of the 7- and 7 × 7-stranded cables also are measured. These values are in good agreement with the predicted values based on the mutual inductance among the strands. It is concluded that the unbalance of the current distribution in the superconducting multistrands can be one of the promising causes for the degradation of the critical current value.     

Comparison of the radiation dose in a cardiac IVR X-ray system

In this study, the entrance surface dose rates received by a phantom during cineangiography and fluoroscopy were compared. The X-ray conditions used in the measurements were those normally used in facilities performing percutaneous coronary intervention. Although, today, the entrance surface doses (cineangiography and fluoroscopy) of X-ray equipment used for cardiac interventional radiology (IVR) tends to be lower than they were previously, some equipment produces a high radiation dose. Therefore, the X-ray equipment used for cardiac IVR procedures must be maintained in good repair and must be carefully calibrated. In addition, periodic measurement of the radiation dose from the X-ray equipment used for both cineangiography and fluoroscopy for cardiac IVR is necessary. If the radiation dose of the X-ray system in use is too high, the IVR staff should determine the reason and make an effort to reduce it. Hence, the IVR staff must be adequately trained in radiation protection.     

Specific IgA and IgG antibodies to house dust mite Dermatophagoides farinae in nasal secretions

As far as we know, IgA and IgG antibodies to purified house dust mite allergens Der fI and Der fII in nasal secretions have never been documented. Therefore, we determined specific IgA, SIgA and IgG antibodies (abs) to crude extract of D. farinae and its purified allergens Der fI and der f II in nasal secretions collected by aspiration from 34 normal subjects, 25 untreated nasal allergic patients and 28 treated nasal allergic patients on parenteral immunotherapy by means of an avidin-biotin ELISA. The following results were obtained. (1) The specific IgA, SIgA and IgG abs to each of the three kinds of allergens correlated with each other. The groups of patients with nasal allergy (both treated and untreated) showed higher levels of specific IgA, SIgA and IgG abs to the allergens than the normal group. (2) In the group of treated patients, the levels of specific abs were not correlated with the clinical improvement of symptoms or the degree of response to nasal challenge. (3) The treated patients failed to show significantly higher levels of abs in nasal secretions than the untreated patients. (4) The specific IgA and SIgA abs in nasal secretions seemed to be predominantly produced locally, and IgG abs might be transudated from the circulation.     

A mesenchymal malignant mesothelioma that changed from mixed type to purely sarcomatous type]

STUDY OBJECTIVE: To evaluate the long-term efficacy of laparoscopic Burch urethropexy. DESIGN: Pilot study. SETTING: Private practice. PATIENTS: Thirty-five consecutive women (average age 45.5 yrs, average parity 2.3, average weight 67.7 kg) treated for genuine stress incontinence between May 1992 and July 1994. INTERVENTIONS: Urethropexy was performed with curved needle suturing in 7 women, straight needle suturing in 5, and Stamey needle suturing in 23. Twenty-five (71.4%) patients had concomitant pelvic surgery. MEASUREMENTS AND MAIN RESULTS: Wilcoxon two-sample, chi2, and Fisher's exact tests were performed to determine which variables were significantly associated with surgical success. Average operating time was 190 minutes, hospitalization 24 hours, and catheterization 5 days. The cure rate of stress incontinence was 89% 3 months and 86% 1 year after surgery. At average follow-up of 34 months, only 68.6% of patients reported complete or almost complete cure, 11.4% were improved, and 20% were complete failures. The only operative variable approaching statistical significance for predicting surgical success was type of suture needle (p = 0.07), with the Stamey needle group having the highest cure rate. Women who were cured or almost cured had a significantly shorter follow-up than those who were improved or failures (p = 0.001). CONCLUSION: The success rate of laparoscopic Burch urethropexy compares with that of open Burch procedure at 1 year, but drops considerably thereafter.