Breakdown characteristics of gas‐insulated switchgear for nonstandard lightning impulse waveforms under nonuniform electric field

To improve the insulation specification of gas‐insulated switchgear (GIS), it is necessary to recognize the insulation characteristics of SF₆ gas during actual surges (called nonstandard lightning impulse waveforms) occurring at field substations. The authors observed the insulation characteristics of SF₆ gas gap under various types of nonstandard lightning impulse waveforms and compared them quantitatively with those obtained with standard lightning impulse waveforms. The experimental results were used to derive an evaluation method for real surges, which was applied to typical surges for various UHV and 500‐kV systems. In the preceding study, therefore, only the case of a quasi‐uniform electric field (with a typical range of field utilization factors in the bus of a GIS) was investigated. In the present investigation, the insulation characteristics of an SF₆ gas gap for a nonuniform electric field were observed experimentally and an evaluation method for converting nonstandard lightning impulse waveforms equivalently to the standard lightning impulse waveform was investigated. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 177(1): 11–18, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21144     

Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

Kupffer cells reside within the liver sinusoid and serve as gatekeepers. They produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as Toll-like receptors. Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupffer cells. In this paper, we review the importance of Kupffer cells in murine acute liver injuries and focus on the following two models: lipopolysaccharide (LPS)-induced liver injury, which is induced by priming with Propionibacterium acnes and subsequent challenge with LPS, and hypercoagulability-mediated acute liver failure such as that in concanavalin A (Con A)-induced hepatitis. Kupffer cells are required for LPS sensitization induced by P. acnes and are a major cellular source of interleukin-18, which induces acute liver injury following LPS challenge. Kupffer cells contribute to Con A-induced acute liver failure by initiating pathogenic, intrasinusoidal thrombosis in collaboration with sinusoidal endothelial cells. The mechanisms underlying these models may shed light on human liver injuries induced by various etiologies such as viral infection and/or abnormal metabolism.     

Behaviors of micro‐layer in micro‐channel boiling system applying laser extinction method

To elucidate the mechanism and characteristics of boiling heat transfer in a micro‐channel vaporizer, the experimental investigation of the micro‐layer thickness that formed between the heating surface and vapor generated was important. The micro‐layer thickness was measured applying the laser extinction method for channel gap sizes of 0.5, 0.3, and 0.15 mm. It was clarified that the gap size, the rate of bubble growth, and the distance from the incipient bubble site have an effect on the micro‐layer thickness in a micro‐channel boiling system. The initial micro‐layer thickness grew with an increase of the velocity of bubble forefront to moderate the value of the velocity. In the region of greater velocity, the thickness was constant for each gap. The distributions of the initial thickness of micro‐layer on the heat transfer surface were shown. © 2005 Wiley Periodicals, Inc. Heat Trans Asian Res, 35(1): 35–46, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.20096     

Photocarrier generation in organic thin-film solar cells with an organic heterojunction

Photocurrent–voltage characteristics for organic solar cells with a heterojunction formed between copper phthalocyanine and a perylene derivative (or C₆₀) were studied. The photocurrent was observed under both reverse and forward biases. From the analysis of the photocurrent action spectra, the origin of the reverse photocurrent was attributed to the excitons formed in both the organic layers, whereas that of the forward photocurrent was attributed to the excitons formed in the perylene derivative (or C₆₀) layer. The photocurrent density under reverse bias increased at higher temperatures, suggesting that the charge recombination possibility was lowered at higher temperatures. On the basis of the time responses of the photocurrents observed after pulsed photoirradiation, the charge separation and transport processes are discussed.     

Changes in capacitance and dielectric dissipation factor of water‐treed XLPE with applied voltage

The capacitance C and dielectric dissipation factor tan δ of a water‐treed XLPE sheet sample have been measured under the application of 100 V or 1 kV at 60 Hz. The values of C and tan δ at 1 kV are much larger than those at 100 V. The value of tan δ gradually decreases with the length of exposure to a voltage of 1 kV. On the other hand, C is almost constant versus the exposure time. The results have been discussed on the basis of a model in which filling of channels interconnecting voids by water is taken into account. It has been found that the increase of C and tan δ is caused by the growth of the water‐filled channel region on the application of voltage. The gradual decrease in tan δ with the exposure time is explained by the change in the conductivity of the water‐filled channel region, as a result of which the relaxation time shifts to higher frequencies. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 144(1): 12–20, 2003; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10160     

Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma

BACKGROUND/AIMS: Hepatocyte growth factor (HGF) is a stromally derived protein growth factor that modulates epithelial cell proliferation and motility. HGF may therefore be involved in tumor progression. METHODOLOGY: We measured the immunoreactive (ir)-HGF concentration in the sera of 56 patients with human gastric carcinoma, using an enzyme-linked immunosorbent assay and evaluated its association with clinical and histopathologic factors. Clinical stages were classified in accordance with The General Rules for TNM Classification (International Union Against Cancer). RESULTS: The serum hHGF concentrations from patients with gastric carcinoma significantly increased with increasing pathologic tumor grades. Also, there were significantly higher concentrations in patients with nodal metastasis compared to patients without metastasis. The serum hHGF concentrations in patients with liver metastasis were significantly higher than in patients without liver metastasis. CONCLUSIONS: These data show that the serum hHGF concentration is elevated in gastric carcinoma patients with liver and nodal metastasis. In multivariate analysis, the serum hHGF concentration was found to be the most important independent factor in predicting overall survival. Thus, the current results suggest that HGF may be important in the progression and metastasis of gastric carcinoma.     

Effect of transfection with a superoxide dismutase expression plasmid on xanthine/xanthine oxidase-induced cytotoxicity in cultured rat lung cells

We inserted human Cu, Zn-superoxide dismutase (hSOD) cDNA into the eukaryotic expression plasmid (pRc/CMV) under the control of the cytomegalovirus promoter. The hSOD expression plasmid (pRc/CMV-SOD) was transfected in L2 cells by mean of lipofection. The intracellular SOD activity in pRc/CMV-SOD transfected cells (CMV-SOD cells) was about twice that in host cells. However the level of extracellular SOD activity was similar in CMV-SOD and host cells. When exposed to xanthine (X)/xanthine oxidase (XO) to generate active oxygen species, significantly more CMV-SOD cells than host cells survived. The production of lipid peroxidation in host cells significantly increased in the presence of X/XO, but that in CMV-SOD cells did not change. Thus, transfection with SOD gene effectively prevented X/XO-induced cytotoxicity. The results indicated that increasing the level of intracellular SOD activity protected cells against extracellular superoxide anion stress.