Direct Enantioselective Three‐Component Kabachnik–Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts

A direct three‐component reaction of aldehydes, amines and diaryl phosphites was catalyzed by a zinc(II) complex of 1,3‐bis(imidazolin‐2‐ly)pyridine (pybim) giving the corresponding α‐aminophosphonates in good yield with good enantioselectivity. The reaction was applied to a wide variety of aromatic aldehydes to give products with excellent yields (up to 99%) and enantiomeric excesses (up to 93% ee).     

Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins

The organocatalytic enantioselective decarboxylative addition of malonic acids half thioesters to isatins using a squaramide catalyst afforded the products with high enantioselectivity. These products are key intermediates in the synthesis of 3‐substituted 3‐hydroxy‐2‐oxindole derivatives. The first enantioselective synthesis of (−)‐flustraminol B has been accomplished.     

Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography

High-speed complex full-range Fourier domain optical coherence tomography (FD-OCT) is demonstrated. In this FD-OCT, the phase modulation of a reference beam (M scan) and transversal scanning (B scan) are simultaneously performed. The Fourier transform method is applied along the direction of the B scan to reconstruct complex spectra, and the complex spectra comprise a full-range OCT image. Because of this simultaneous B-M-mode scan, the FD-OCT requires only a single A scan for each single transversal position to obtain a full-range FD-OCT image. A simple but slow version of the FD-OCT visualizes the cross section of a plastic plate. A modified fast version of this FD-OCT investigates a sweat duct in a finger pad in vivo and visualizes it with an acquisition time of 27 ms.     

Room temperature aging behavior of Ti-Nb-Mo-based superelastic alloys

The effect of room temperature (RT) aging on the superelasticity of Ti-Nb-Mo-based superelastic alloys is investigated. The results show that annealing at relatively low temperatures such as 973 K after severe cold rolling results in poor resistance to the effect of RT aging. The transformation stress increases considerably due to the formation of an isothermal ω phase at RT. Addition of Sn is partially effective in suppressing the RT aging effect in the specimens annealed at 973 K. The RT aging effect is suppressed by increasing the annealing temperature, due to the annihilation of lattice defects or non-equilibrium vacancies introduced during cold rolling, which are responsible for accelerating the diffusion process, however, superelasticity is reduced by annealing at higher temperatures, due to a decrease in the critical stress for slip deformation (σ_CSS). The specimen annealed at 1173 K followed by aging at 773 K exhibits stable superelasticity with a high resistance to the effect of RT aging. Annealing at 1173 K causes the annihilation of lattice defects or non-equilibrium vacancies, while aging at 773 K induces precipitation of the α phase, which in turn causes an increase in σ_CSS, and further enhances the resistance to the RT aging effect by enriching the matrix with β-stabilizing elements.     

Microfluidic Automation Using Elastomeric Valves and Droplets: Reducing Reliance on External Controllers

This paper gives an overview of elastomeric valve‐ and droplet‐based microfluidic systems designed to minimize the need of external pressure to control fluid flow. This Concept article introduces the working principle of representative components in these devices along with relevant biochemical applications. This is followed by providing a perspective on the roles of different microfluidic valves and systems through comparison of their similarities and differences with transistors (valves) and systems in microelectronics. Despite some physical limitation of drawing analogies from electronic circuits, automated microfluidic circuit design can gain insights from electronic circuits to minimize external control units, while implementing high‐complexity and high‐throughput analysis.     

Enhancement of oxygen reduction activity with addition of carbon support for non-precious metal nitrogen doped carbon catalyst

An improved synthesis scheme of non-precious metal N-doped carbon catalysts for oxygen reduction reaction is reported. The non-precious metal N-doped carbon catalysts were prepared by pyrolysis of the mixture (phenol resin, Ketjen black carbon support and cobalt phenanthroline complex). The drastic improvement of distribution state of Ketjen black supported non-precious metal N-doped carbon catalysts was observed by means of transmission electron microscopy (TEM). In addition, the non-precious metal N-doped carbon catalyst synthesized with Ketjen black carbon support showed much higher oxygen reduction reaction (ORR) activity relative to unsupported non-precious metal N-doped carbon catalyst in O₂-saturated 0.5 mol l⁻¹ H₂SO₄ at 35 °C. Moreover, the highest ORR activity was obtained with addition of optimum amount of Ketjen black carbon support was thirtyfold compared to unsupported non-precious metal N-doped carbon catalyst at 0.7 V. Similarly, the performance of a polymer electrolyte fuel cell (PEFC) using the non-precious metal N-doped carbon catalyst as the cathode electrode catalyst was obviously better than that of the non-precious metal N-doped carbon catalyst before optimization. Microstructure, specific surface area and surface composition of the non-precious metal N-doped carbon catalysts were analyzed by XRD, XPS and BET measurement with nitrogen physisorption, respectively.     

Field survey on energy consumption due to hot water supply and cooking in Nanjing and Hefei,China

A field survey on energy consumption by hot water supply and cooking was conducted in two cities in China, Nanjing, and Hefei. In each city, 5 housing complexes were selected, and approximately 100 or 200 residential units were selected from each of them. The following items were surveyed: (1) fundamental information, such as number of family members, data on residents, etc., (2) bathing style, and (3) frequency of cooking and cooking time. Most of the residents take showers seven times a week in the summer, but less frequently in the winter. In contrast, the frequency of taking baths increases to several times a week during the winter, compared with 0 or 1 times a week in the summer. These results differ slightly depending on the heating and cooling systems used in the houses. The frequency with which people cook in their own houses ranges from 4 to 7 times a week, which means that “eating out” is relatively frequent, although the result differs significantly among the housing complexes. Distribution of the cooking time has usually two peaks at 20 to 30 min and 50 to 60 min (or 30 to 40 min and longer than 60 min) for lunch and dinner, respectively. The high energy consumption for cooking might be due to the long cooking time.     

TEM analysis of high temperature annealed W nanostructure surfaces

Helium plasma irradiation and electron heating experiments were conducted using tungsten in the divertor simulator NAGDIS-II. Helium plasma irradiation to tungsten led to the formation of nanostructures on the surface, while the nanostructures were annihilated after the potential of the specimen was changed to positive for several 10 min so that electrons irradiated the sample without ion irradiation. The specimens were analyzed in detail by transmission electron microscope with the help of focused ion beam technique. It is revealed that the helium nano-bubbles still remained even after the nanostructures were disappeared from the surface. Porosity of the nanostructured tungsten was measured from the TEM images.     

Optimizing process allocation of parallel programs for heterogeneous clusters

The performance of a conventional parallel application is often degraded by load‐imbalance on heterogeneous clusters. Although it is simple to invoke multiple processes on fast processing elements to alleviate load‐imbalance, the optimal process allocation is not obvious. Kishimoto and Ichikawa presented performance models for high‐performance Linpack (HPL), with which the sub‐optimal configurations of heterogeneous clusters were actually estimated. Their results on HPL are encouraging, whereas their approach is not yet verified with other applications. This study presents some enhancements of Kishimoto's scheme, which are evaluated with four typical scientific applications: computational fluid dynamics (CFD), finite‐element method (FEM), HPL (linear algebraic system), and fast Fourier transform (FFT). According to our experiments, our new models (NP‐T models) are superior to Kishimoto's models, particularly when the non‐negative least squares method is used for parameter extraction. The average errors of the derived models were 0.2% for the CFD benchmark, 2% for the FEM benchmark, 1% for HPL, and 28% for the FFT benchmark. This study also emphasizes the importance of predictability in clusters, listing practical examples derived from our study. Copyright © 2008 John Wiley & Sons, Ltd.