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11.
María A. Núez-Snchez Silvia Melgar Keith ODonoghue María A. Martínez-Snchez Virgina E. Fernndez-Ruiz Mercedes Ferrer-Gmez Antonio J. Ruiz-Alcaraz Bruno Ramos-Molina 《International journal of molecular sciences》2022,23(15)
Crohn’s disease (CD) is a complex, disabling, idiopathic, progressive, and destructive disorder with an unknown etiology. The pathogenesis of CD is multifactorial and involves the interplay between host genetics, and environmental factors, resulting in an aberrant immune response leading to intestinal inflammation. Due to the high morbidity and long-term management of CD, the development of non-pharmacological approaches to mitigate the severity of CD has recently attracted great attention. The gut microbiota has been recognized as an important player in the development of CD, and general alterations in the gut microbiome have been established in these patients. Thus, the gut microbiome has emerged as a pre-eminent target for potential new treatments in CD. Epidemiological and interventional studies have demonstrated that diet could impact the gut microbiome in terms of composition and functionality. However, how specific dietary strategies could modulate the gut microbiota composition and how this would impact host–microbe interactions in CD are still unclear. In this review, we discuss the most recent knowledge on host–microbe interactions and their involvement in CD pathogenesis and severity, and we highlight the most up-to-date information on gut microbiota modulation through nutritional strategies, focusing on the role of the microbiota in gut inflammation and immunity. 相似文献
12.
Michela Pecoraro Stefania Marzocco Silvia Franceschelli Ada Popolo 《International journal of molecular sciences》2022,23(12)
Human epidermal growth factor receptor-2 (HER2) is overexpressed in up to 30% of breast cancer cases, causing a more aggressive tumour growth and poor prognosis. Trastuzumab, the humanized antibody targeted to HER2, increased the life expectancy of patients, but severe cardiotoxicity emerged as a long-term adverse effect. Clinical evidence highlights that Trastuzumab-induced cardiotoxicity drastically increases in association with Doxorubicin; however, the exact mechanisms involved remain incompletely understood. In order to analyse the molecular mechanisms involved and the possible adaptative responses to Trastuzumab and Doxorubicin treatment, in this study, H9c2 cardiomyoblasts were used. Results showed that Trastuzumab and Doxorubicin sequential administration in cardiomyoblast increased cytosolic and mitochondrial ROS production, intracellular calcium dysregulation, mitochondrial membrane depolarization, and the consequent apoptosis, induced by both Trastuzumab and Doxorubicin alone. Furthermore, in these conditions, we observed increased levels of Connexin43 phosphorylated on Ser368 (pCx43). Since phosphorylation on Ser368 decreases gap junction intracellular communication, thus reducing the spread of death signals to adjacent cells, we hypothesized that the increase in pCx43 could be an adaptative response implemented by cells to defend neighbouring cells by Trastuzumab and Doxorubicin sequential administration. However, the other side of the coin is the resulting conduction abnormalities. 相似文献
13.
Gaetana Paolella Silvia Sposito Antonio Massimiliano Romanelli Ivana Caputo 《International journal of molecular sciences》2022,23(14)
Type 2 transglutaminase (TG2) is the main autoantigen in coeliac disease (CD), a widespread inflammatory enteropathy caused by the ingestion of gluten-containing cereals in genetically predisposed individuals. As a consequence, serum antibodies to TG2 represent a very useful marker in CD diagnosis. However, TG2 is also an important player in CD pathogenesis, for its ability to deamidate some Gln residues of gluten peptides, which become more immunogenic in CD intestinal mucosa. Given the importance of TG2 enzymatic activities in CD, several studies have sought to discover specific and potent inhibitors that could be employed in new therapeutical approaches for CD, as alternatives to a lifelong gluten-free diet. In this review, we summarise all the aspects regarding TG2 involvement in CD, including its enzymatic reactions in pathogenesis, the role of anti-TG2 antibodies in disease management, and the exploration of recent strategies to reduce deamidation or to use transamidation to detoxify gluten. 相似文献
14.
15.
Silvia Carra Germano Gaudenzi Alessandra Dicitore Maria Celeste Cantone Alice Plebani Davide Saronni Silvia Zappavigna Michele Caraglia Alessia Candeo Andrea Bassi Luca Persani Giovanni Vitale 《International journal of molecular sciences》2022,23(15)
Lung carcinoids are neuroendocrine tumors that comprise well-differentiated typical (TCs) and atypical carcinoids (ACs). Preclinical models are indispensable for cancer drug screening since current therapies for advanced carcinoids are not curative. We aimed to develop a novel in vivo model of lung carcinoids based on the xenograft of lung TC (NCI-H835, UMC-11, and NCI-H727) and AC (NCI-H720) cell lines and patient-derived cell cultures in Tg(fli1a:EGFP)y1 zebrafish embryos. We exploited this platform to test the anti-tumor activity of sulfatinib. The tumorigenic potential of TC and AC implanted cells was evaluated by the quantification of tumor-induced angiogenesis and tumor cell migration as early as 24 h post-injection (hpi). The characterization of tumor-induced angiogenesis was performed in vivo and in real time, coupling the tumor xenograft with selective plane illumination microscopy on implanted zebrafish embryos. TC-implanted cells displayed a higher pro-angiogenic potential compared to AC cells, which inversely showed a relevant migratory behavior within 48 hpi. Sulfatinib inhibited tumor-induced angiogenesis, without affecting tumor cell spread in both TC and AC implanted embryos. In conclusion, zebrafish embryos implanted with TC and AC cells faithfully recapitulate the tumor behavior of human lung carcinoids and appear to be a promising platform for drug screening. 相似文献
16.
Vincenzo Fiorentino Pietro Tralongo Maurizio Martini Silvia Betti Elena Rossi Francesco Pierconti Valerio De Stefano Luigi Maria Larocca 《International journal of molecular sciences》2022,23(14)
Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) represent a group of hematological disorders that are traditionally considered as indistinct slow progressing conditions; still, a subset of cases shows a rapid evolution towards myelofibrotic bone marrow failure. Specific abnormalities in the megakaryocyte lineage seem to play a central role in this evolution, especially in the bone marrow fibrosis but also in the induction of myeloproliferation. In this review, we analyze the current knowledge of prognostic factors of MPNs related to their evolution to myelofibrotic bone marrow failure. Moreover, we focused the role of the megakaryocytic lineage in the various stages of MPNs, with updated examples of MPNs in vitro and in vivo models and new therapeutic implications. 相似文献
17.
Silvia Mara Baez Rodriguez Georgiana-Adeline Staicu Ani-Simona Sevastre Carina Baloi Vasile Ciubotaru Anica Dricu Ligia Gabriela Tataranu 《International journal of molecular sciences》2022,23(9)
Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most standard treatments fail to completely eradicate GSCs, causing the recurrence of the disease. GSCs could represent one reason for the low efficacy of cancer therapy and for the short relapse time. Nonetheless, experimental data suggest that the presence of therapy-resistant GSCs could explain tumor recurrence. Therefore, to effectively target GSCs, a comprehensive understanding of their biology and the survival and developing mechanisms during treatment is mandatory. This review provides an overview of the molecular features, microenvironment, detection, and targeting strategies of GSCs, an essential information required for an efficient therapy. Despite the outstanding results in oncology, researchers are still developing novel strategies, of which one could be targeting the GSCs present in the hypoxic regions and invasive edge of the glioblastoma. 相似文献
18.
Silvia Nappini Danil W. Boukhvalov Gianluca D'Olimpio Libo Zhang Barun Ghosh Chia‐Nung Kuo Haoshan Zhu Jia Cheng Michele Nardone Luca Ottaviano Debashis Mondal Raju Edla Jun Fuji Chin Shan Lue Ivana Vobornik Jory A. Yarmoff Amit Agarwal Lin Wang Lixue Zhang Federica Bondino Antonio Politano 《Advanced functional materials》2020,30(22)
By means of theory and experiments, the application capability of nickel ditelluride (NiTe2) transition‐metal dichalcogenide in catalysis and nanoelectronics is assessed. The Te surface termination forms a TeO2 skin in an oxygen environment. In ambient atmosphere, passivation is achieved in less than 30 min with the TeO2 skin having a thickness of about 7 Å. NiTe2 shows outstanding tolerance to CO exposure and stability in water environment, with subsequent good performance in both hydrogen and oxygen evolution reactions. NiTe2‐based devices consistently demonstrate superb ambient stability over a timescale as long as one month. Specifically, NiTe2 has been implemented in a device that exhibits both superior performance and environmental stability at frequencies above 40 GHz, with possible applications as a receiver beyond the cutoff frequency of a nanotransistor. 相似文献
19.
Massimo Conti Paolo Crippa Simone Orcioni Marcello Pesare Claudio Turchetti Loris Vendrame Silvia Lucherini 《Analog Integrated Circuits and Signal Processing》2003,37(2):85-102
In this paper a novel CAD methodology for yield enhancement of VLSI CMOS circuits including random device variations is presented. The methodology is based on a preliminary characterization of the technological process by means of specific test chips for accurate mismatch modeling. To this purpose, a very accurate position-dependent parameter mismatch model has been formulated and extracted. Finally a CAD tool implementing this model has been developed. The tool is fully integrated in an environment of existing commercial tools and it has been experimented in the STMicroelectronics Flash Memory CAD Group.As an example of application, a bandgap reference circuit has been considered and the results obtained from simulations have been compared with experimental data. Furthermore, the methodology has been applied to the read path of a complex Flash Memory produced by STMicroelectronics, consisting of about 16,000 MOSFETs. Measurements of electrical performances have confirmed the validity of the methodology, and the accuracy of both the mismatch model and the simulation flow. 相似文献
20.
Daniele Passeri Ugo Sassi Andrea Bettucci Emanuela Tamburri Francesco Toschi Silvia Orlanducci Maria Letizia Terranova Marco Rossi 《Advanced functional materials》2012,22(14):2956-2963
The thermoacoustic effect of isolated single‐wall carbon nanotubes aligned between electrodes is experimentally observed for the first time by imaging the emitted acoustic wave using an atomic force microscopy‐based technique specifically developed for the task. The capability of such a technique for single‐point thermoacoustic measurements is first verified on carbon nanotubes layers with two electrodes for injecting alternate electric current. The technique is then demonstrated to allow the acquisition, simultaneously with the topography, of images reflecting the pressure of the acoustic wave at fixed distance from the sample. Such a capability is used to collect images reflecting the amplitude of acoustic waves generated by isolated nanotubes and nanotube bundles by the thermoacoustic effect. 相似文献