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71.
Daniela Lisini Sara Lettieri Sara Nava Giulia Accordino Simona Frigerio Chandra Bortolotto Andrea Lancia Andrea Riccardo Filippi Francesco Agustoni Laura Pandolfi Davide Piloni Patrizia Comoli Angelo Guido Corsico Giulia Maria Stella 《International journal of molecular sciences》2021,22(16)
Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so far in the MPM. Combination immunotherapy might achieve better results over chemotherapy alone, but there is still a need for more effective therapeutic approaches. Based on the peculiar disease features of MPM, several strategies for local therapeutic delivery have been developed over the past years. The common rationale of these approaches is: (i) to reduce the risk of drug inactivation before reaching the target tumor cells; (ii) to increase the concentration of active drugs in the tumor micro-environment and their bioavailability; (iii) to reduce toxic effects on normal, non-transformed cells, because of much lower drug doses than those used for systemic chemotherapy. The complex interactions between drugs and the local immune-inflammatory micro-environment modulate the subsequent clinical response. In this perspective, the main interest is currently addressed to the development of local drug delivery platforms, both cell therapy and engineered nanotools. We here propose a review aimed at deep investigation of the biologic effects of the current local therapies for MPM, including cell therapies, and the mechanisms of interaction with the tumor micro-environment. 相似文献
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Mawase F Bar-Haim S Karniel A 《IEEE transactions on neural systems and rehabilitation engineering》2011,19(6):686-695
To date, research on the motor control of hand function in cerebral palsy has focused on children with hemiplegia, although many persons with diplegic cerebral palsy (dCP) have asymmetrically decreased hand function. We explored the predictive capabilities of the motor system in a simple motor task of lifting a series of virtual objects for five persons with spastic dCP and five age-matched controls. When a person lifts an object, s/he uses an expectation of the weight of the object to generate a motor command. We asked the study subjects to lift a series of increasing weights and determined whether they extrapolated from past experience to predict the next weight in the series, even though that weight had never been experienced. Planning of precision grasp was assessed by measurement of the grip force at the beginning of the lifting task and by estimating the motor command. Execution of precision grasp was assessed by measurement of the time interval between the onset of grip and the onset of movement. We found that persons with dCP demonstrated a lack of predictive feed-forward control in their lifting movements: they exhibited a significantly longer time between onset of grip and onset of movement than the control subjects and they did not predict the weight of the next object in the lifting task. In addition, for subjects with dCP, the time between the onset of grip and the onset of movement of the dominant hand correlated strongly with the outcome of a hand function test. We postulate that a higher-order motor planning deficit in addition to execution deficit are evident in the subjects with spastic diplegic. 相似文献
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Federico Aulenta Andrea Canosa Luigi De Roma Priscilla Reale Stefania Panero Simona Rossetti Mauro Majone 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2009,84(6):864-870
BACKGROUND: A bioelectrochemical process for trichloroethene (TCE) dechlorination was developed. In this new process, a solid‐state electrode polarized to ?450 mV versus the standard hydrogen electrode (SHE), in combination with a redox mediator (i.e., methyl viologen, MV) is employed as an electron donor for the microbial reductive dechlorination of TCE. In this study we compared the performance of the process with the redox mediator immobilized at the surface of electrodes or dissolved in the bulk liquid, using both a culture highly enriched in Desulfitobacterium spp., capable of dechlorinating TCE to cis‐dichloroethene (cis‐DCE), and a culture highly enriched in Dehalococcoides spp. capable of dechlorinating cis‐DCE to ethene. RESULTS: Short‐term potentiostatic (?450 mV versus SHE) experiments showed that TCE or cis‐DCE was dechlorinated both in the presence of soluble (500 µmol L?1) and immobilized MV. However, TCE or cis‐DCE dechlorination rates with MV‐modified electrodes were remarkably lower than with soluble MV. Both cultures produced significant amounts of H2 in the presence of electrically reduced, soluble MV, whereas no H2 was produced when the mediator was immobilized at the electrode surface, regardless of the potential applied to the electrode, in the range ?425 to ?500 mV versus SHE. CONCLUSIONS: The process, operated with modified electrodes, supports the microbial dechlorination of TCE to ethene. Immobilization not only allows retention of the mediator within the system, but also increases process efficiency by preventing bioelectrochemical H2 formation. On the other hand, strategies to increase dechlorination rates with modified electrodes need to be developed. Copyright © 2009 Society of Chemical Industry 相似文献
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Orthonasal or retronasal presentation of odorants evokes different responses. To study this phenomenon in depth, a stimulation technique has been developed that allows ortho- or retronasal presentation of chemosensory stimuli, the release of which is precisely controlled. Based on this technique studies have been conducted using psychophysical, electrophysiological, and imaging techniques. In conjunction with clinical data the results clearly suggest that there are differences in the perception of ortho- and retronasal stimuli. The basis for this phenomenon may be found in ideas by Mozell and colleagues with regard to odorant absorption across the mucosa which may determine activation of the olfactory epithelium. 相似文献
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Andrea Scaccabarozzi Simona Binetti Maurizio Acciarri Giovanni Isella Roberta Campesato Gabriele Gori Maria Cristina Casale Fulvio Mancarella Michael Noack Hans von Knel Leo Miglio 《Progress in Photovoltaics: Research and Applications》2016,24(10):1368-1377
We report preliminary results on InGaP/InGaAs/Ge photovoltaic cells for concentrated terrestrial applications, monolithically integrated on engineered Si(001) substrates. Cells deposited on planar Ge/Si(001) epilayers, grown by plasma‐enhanced chemical vapor deposition, provide good efficiency and spectral response, despite the small thickness of the Ge epilayers and a threading dislocation density as large as 107/cm2. The presence of microcracks generated by the thermal misfit is compensated by a dense collection grid that avoids insulated areas. In order to avoid the excessive shadowing introduced by the use of a dense grid, the crack density needs to be lowered. Here, we show that deep patterning of the Si substrate in blocks can be an option, provided that a continuous Ge layer is formed at the top, and it is suitably planarized before the metalorganic chemical vapor deposition. The crack density is effectively decreased, despite that the efficiency is also lowered with respect to unpatterned devices. The reasons of this efficiency reduction are discussed, and a strategy for improvement is proposed and explored. Full morphological analysis of the coalesced Ge blocks is reported, and the final devices are tested under concentrated AM1.5D spectrum. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献